Ask about this productRelated genes to: SH3BGRL3 antibody
- Gene:
- SH3BGRL3 NIH gene
- Name:
- SH3 domain binding glutamate rich protein like 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-26
- Date modifiied:
- 2016-01-29
Related products to: SH3BGRL3 antibody
Related articles to: SH3BGRL3 antibody
- - Source: PubMed
Publication date: 2026/04/27
Wang LiLu FeiGao JingyanLi YanliLi SongqinLi ManDong Renyi - Previous genome-wide association studies (GWAS) have identified several risk genes for stroke; however, it remains unclear how they confer risk for the disease. We conducted an integrative analysis to identify candidate genes for stroke and stroke subtypes by integrating blood-derived multi-omics data with genetic data. We systematically integrated the latest stroke GWAS database with human plasma proteomes and performed proteome-wide association studies, Mendelian randomization (MR), Bayesian colocalization analysis and transcriptome-wide association study to prioritize genes that associate the risk of stroke and its subtypes with their expression and protein abundance in plasma. The target genes were verified by performing tissue and cell type specificity, and functional analysis using the Genotype-Tissue Expression database, single-cell RNA sequencing and Gene Ontology databases. A two-step MR analysis was followed to explore the potential mechanisms. We found that the protein abundance of seven genes ( and ) in the plasma was associated with stroke and its subtypes, and six genes ( and ) causally related with stroke and its subtypes. The effect of and on each subtype was mediated by Factor XI inhibitors, atrial fibrillation, type 2 diabetes and systolic blood pressure, respectively ( < 0.05). We also found that and were related to stroke and ischemic stroke at the transcriptome level. Our present proteomic findings may offer potential future therapeutic targets for stroke prevention. - Source: PubMed
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Zhao Xu-SongFang BoTian Cang-YuCui Yan-KangShen Tian-YiWang Su-ChunTang HaoWu MengXu Feng - Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with early diagnosis remaining a significant challenge. Available serum biomarkers lack specificity, making it difficult to accurately identify early non-metastatic GC cases. Reliable diagnostic biomarkers that can detect early GC are critical to improve prognosis. - Source: PubMed
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Liu YifanDong KeqinYao YuntaoLu BingnanWang LeiJi GuoZhang HaoyuZhao ZihuiYang XinyueHuang RunzhiZhou WangPan XiuwuCui Xingang