Ask about this productRelated genes to: SH2D4A antibody
- Gene:
- SH2D4A NIH gene
- Name:
- SH2 domain containing 4A
- Previous symbol:
- -
- Synonyms:
- FLJ20967, SH2A, PPP1R38
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-16
- Date modifiied:
- 2016-10-05
Related products to: SH2D4A antibody
Related articles to: SH2D4A antibody
- Ruminant meat is an important component of human diets, valued for its unique flavor and nutritional density. Lipids play a dominant role in shaping meat flavor, yet their genetic and biochemical basis remains unexplored. Here, from the analysis of 434 sheep longissimus thoracis samples, the current study presents the first comprehensive lipid map of sheep meat, including 947 lipids. A substantial proportion of these lipids exhibit moderate-to-high heritability, with 51.6% surpassing a heritability of 0.2 and 15.8% exceeding 0.45. Metabolome-based genome-wide association analysis identifies 467 significant loci affecting 233 lipids, including 110 loci exhibiting pleiotropy. Notably, the levels of monogalactosyldiacylglycerols containing oleic (C18:1) and linoleic (C18:2) acids are specifically regulated by the expression of MBOAT1 and PAQR8 genes, respectively, while 13 triglycerides and one diglyceride are co-regulated by SH2D4A. The levels of phosphatidylethanolamine PE(20:4_20:0) are regulated by VPS53. Further examination of volatile compounds demonstrates that variations in these genetically controlled lipids significantly impact flavourant levels in cooked meat. Given the conservation of lipid profiles and genomes among ruminants, this study offers novel insights into the genetic architecture underlying meat lipid metabolism and provides a valuable resource for the targeted genetic improvement of ruminant meat flavor. - Source: PubMed
Publication date: 2025/08/11
Zhang XueyingKong YuanyuanChen JialeiLi RanWang ZhongyuSong YaliDai TianshuFu YuxinJiang BeixiangZeng JizePei ShengweiLiu YangkaiFeng QianjieFu WeiweiYuan ZehuMwacharo Joram MwashigadiLi FadiYue Xiangpeng - - Source: PubMed
Li ZiyaoXin ShiyongHuang LiqunTian YeChen WeihuaLiu XiangYe BowenBai RongYang GuoshengWang WenwenYe Lin - Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies. Recently, the role of brain-expressed X-linked 4 (BEX4) in cancer progression has received increasing attention. This study aimed to investigate the function of BEX4 in ccRCC and to reveal the underlying mechanisms. We first confirmed that BEX4 was significantly downregulated in ccRCC by bioinformatics analysis and that patients with low BEX4 expression tended to have prolonged overall survival time. Subsequently, we confirmed that BEX4 inhibited ccRCC cell proliferation in vitro and tumorigenesis in vivo through a series of cell function assays and the establishment of a nude mouse xenograft model, respectively. Mechanistically, we found that BEX4 positively regulates the expression of Src homology 2 domain-containing 4A (SH2D4A), an inhibitor of the NOTCH pathway, which further promoted the tumor-suppressive effects of BEX4. In addition, our study confirmed that the promoting effect of BEX4 on SH2D4A was achieved by inhibiting the deacetylase sirtuin 2 (SIRT2) activity. On this basis, we found that there was a competition between acetylation and ubiquitination modifications at the K69 site of SH2DA4 and that BEX4-induced upregulation of acetylation at the k69 site stabilizes SH2D4A protein expression by inhibiting ubiquitination at the same site. In addition, dual-luciferase assays showed that the transcriptional activity of BEX4 was positively regulated by activation transcription factor 3 (ATF3). Our study suggests that BEX4 plays a role in inhibiting tumor progression in ccRCC and maybe a new diagnostic and therapeutic target for ccRCC patients. - Source: PubMed
Publication date: 2024/12/05
Li ZiyaoXin ShiyongHuang LiqunTian YeChen WeihuaLiu XiangYe BowenBai RongYang GuoshengWang WenwenYe Lin - Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer in adults. This study aimed to obtain data on immune cell infiltration based on public datasets and to examine the prognostic significance of SH2 domain containing 4A () for GBM. - Source: PubMed
Publication date: 2024/08/23
Yang TianLi ChujunXu DuoQuan RuiWang LanshengRen YanhongZhang ZhengkuiYu Rutong - - Source: PubMed
Publication date: 2024/02/29
Yuki RyuzaburoIkeda YukiYasutake RyujiSaito YouheiNakayama Yuji