Ask about this productRelated genes to: SERPINB12 antibody
- Gene:
- SERPINB12 NIH gene
- Name:
- serpin family B member 12
- Previous symbol:
- -
- Synonyms:
- YUKOPIN
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-27
- Date modifiied:
- 2016-04-06
Related products to: SERPINB12 antibody
Related articles to: SERPINB12 antibody
- Increasing evidence from preclinical models has linked the actions of brown adipose tissue (BAT) with protection against atherosclerosis and cardiovascular disease, in part due to its salutary effects on systemic lipid composition. However, human data on the role of BAT in atherosclerosis are scarce. - Source: PubMed
Publication date: 2026/04/30
Kulterer Oana CHerz Carsten TPils DietmarWollenweber TimFritzer-Szekeres MonikaKautzky-Willer AlexandraCalabretta RaffaellaHagn GerhardHacker MarcusGerner ChristopherHaug Alexander RKiefer Florian W - Neuro-immune interactions are critical in cancer, yet their molecular features in bladder cancer remain unclear. We analyzed transcriptomic data from TCGA and UCSC Xena to investigate the expression profiles and molecular subtypes of neuro-immune-related genes, and constructed a neuro-immune-related score (NAS) model. Single-cell transcriptomic data were integrated to explore the immune microenvironmental features, and functional validation was performed by knocking down SERPINE2 with shRNA in T24 cells. The results showed that six core genes (SERPINE2, NXPH4, SERPINB2, C2orf40, SERPINB12, SERPINB10) were identified to stratify patients into high- and low-risk groups, with robust predictive power across clinical subgroups and validation cohorts. Single-cell RNA-seq data revealed significant NAS heterogeneity among cell populations. The NAS-high state was enriched in TGFβ, EGF, and FGF signaling with activation of EZH2 and SMARCA4, while the NAS-low state showed immune-regulatory features. Functional assays confirmed that SERPINE2 knockdown suppressed proliferation, migration, invasion, while increasing apoptosis of T24 cells, highlighting its oncogenic role. Moreover, genome-wide association studies (GWAS) suggested that genetic variants in SERPINE2 and related genes may increase bladder cancer susceptibility. Collectively, our findings provide novel insights into neuro-immune-driven tumor heterogeneity and immune remodeling, establish the NAS model as an innovative prognostic tool, and identify SERPINE2 as a promising therapeutic target for precision management of bladder cancer. - Source: PubMed
Publication date: 2026/03/04
Nie QiweiJiang MinyaoWan SongXi MingHua WeiJiang FunengZhong Weide - Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chronic neuroinflammation, potentially mediated by the release of extracellular particles (EPs), such as extracellular condensates (ECs) and extracellular vesicles (EVs). These particles, which reflect the physiological, pathophysiological, and metabolic states of their cells of origin, might carry molecular signatures indicative of SUD. In particular, our study investigated neuroinflammatory signatures in SUD patients by isolating EVs from the dorsolateral prefrontal cortex (dlPFC) Brodmann's area 9 (BA9) from postmortem subjects. We isolated BA9-derived EVs from postmortem brain tissues of eight individuals (controls: n = 4, SUD: n = 4). The physical properties (concentration, size, zeta potential, morphology) of the EVs were analyzed, and the EVs were subjected to integrative multiomics analysis to profile the lipidomic and proteomic characteristics. We assessed the interactions and bioactivity of EVs by evaluating their uptake by glial cells. We further assessed the effects of EVs on complement mRNA expression in glial cells and on microglial migration. No significant differences in EV concentration, size, zeta potential, or surface markers were observed between the SUD group and the control group. However, lipidomic analysis revealed significant enrichment of glycerophosphoinositol bisphosphate (PIP2) in SUD-derived EVs. Proteomic analysis revealed the downregulation of SERPINB12, ACYP2, CAMK1D, DSC1, and FLNB and the upregulation of C4A, C3, and ALB in SUD-derived EVs. Gene Ontology (GO) and protein‒protein interactome analyses revealed functions associated with the identified proteins, such as cell motility, focal adhesion, and acute phase response signaling. Both control and SUD-derived EVs increased C3 and C4 mRNA expression in microglia, but only SUD-derived EVs upregulated these genes in astrocytes. SUD-EVs also significantly enhanced microglial migration in a wound healing assay. This study successfully isolated EVs from postmortem brains and used a multiomics approach to identify EV-associated lipids and proteins in SUD. Elevated C3 and C4 in SUD-derived EVs and the distinct effects of EVs on glial cells suggest a crucial role for these cells in acute phase response signaling and neuroinflammation. - Source: PubMed
Publication date: 2025/08/15
Okeoma Chioma MNaushad WasifaOkeoma Bryson CGartner CarlosSantos-Ortega YulicaVary CalvinLima-Bastos SavioCarregari Victor CorasollaLarsen Martin RNoghero AlessioWalss-Bass ConsueloGrassi-Oliveira Rodrigo - Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin, which is common in children and adolescents. Long non-coding RNA (lncRNA) SNHG11 plays important regulatory roles in various cancers, particularly in promoting cell migration, invasion, and proliferation. However, the function and regulatory mechanisms of SNHG11 in osteosarcoma remain unclear. In this study, we found that overexpression of SNHG11 in human osteosarcoma U2OS cells significantly inhibited cell proliferation and promoted apoptosis. Overexpression of SNHG11 in U2OS cells resulted in significant differential expression of 344 genes, including 82 upregulated genes and 262 downregulated genes. The upregulated genes were not significantly enriched in GO-P, although HMGCS2 and IL24 may play important roles. The downregulated genes were significantly enriched in GO-P related to cell adhesion and migration, with key genes including KRT17, CXCL14, TRIB2, COL5A1, CCL24, SOX2, and COL6A3.SNHG11 may interact with KRT6B, SERPINB12, and DCD proteins to regulate downstream targets. ChIRP-seq (RNA) sequencing revealed that SNHG11 specifically binds to EEF2, RPS4X, and ACTG1. ChIRP-seq (DNA) sequencing showed that SNHG11 gene was mainly enriched in biological processes such as negative regulation of apoptosis. Integrated analysis of ChIRP-seq (RNA) revealed 32 overlapping genes, suggesting that SNHG11 may contribute to osteosarcoma progression by binding to DCD and regulating these targets. Similarly, ChIRP-seq (DNA) analysis identified 16 overlapping genes. Combined with protein profiling data, we speculate that SNHG11 may be involved in osteosarcoma progression by binding to SERPINB12 and regulating transcription. In conclusion, lncRNA SNHG11 plays a critical role in osteosarcoma development by regulating cellular information carriers at the DNA, RNA, and protein levels. - Source: PubMed
Publication date: 2025/07/15
Dai ZhibingSun YachaoMaihemuti MaierdanjiangDu JunWeiJiang Renbing - Coronavirus 2019 (COVID-19) leads to substantial morbidity and excess mortality all over the world which may be aggravated by the propensity of Severe Acute Respiratory Syndrome Coronavirus 2 to mutate. Mechanisms for development of severe COVID-19 are poorly understood. The air we exhale contains endogenous proteins and represents a highly accessible yet unexploited biological sample that can be collected without use of invasive procedures. We collected exhaled breath condensate samples from 28 patients hospitalised due to COVID-19 at admission and discharge using RTubes™. Bottom-up proteomic analysis of tandem mass-tag-labelled single exhaled breath samples was performed in 25 exhaled breath samples collected at admission and 13 samples collected at discharge using discovery-based nano-liquid chromatography-tandem mass spectrometry. In total, 232 proteins were identified in the exhaled breath samples after stringent data filtering. Most of the exhaled proteins were related to the immune systems function and regulation. The levels of four proteins, KRT77, DCD, CASP14 and SERPINB12 decreased from admission to discharge as patients generally recovered from the infection. These proteins are expressed in lung epithelium or macrophages and are associated with the regulation of inflammation drivers in COVID-19. In particular, the alarmins S100A8 and S100A9 accounted for 8% of the exhaled breath proteins. In conclusion, our study demonstrates that analysis of the exhaled breath protein composition can give insights into mechanisms related to inflammation and response to infections, and hereby also of severe COVID-19.Clinical Trial No: NCT04598620. - Source: PubMed
Publication date: 2025/05/16
Gade Inger LiseBodilsen JacobMariager TheisHertz SandraDuerlund Lærke StorgaardHolm Christian KanstrupMadsen Poul HenningBennike Tue BjergHonoré Bent