Ask about this productRelated genes to: SEMA4A antibody
- Gene:
- SEMA4A NIH gene
- Name:
- semaphorin 4A
- Previous symbol:
- SEMAB
- Synonyms:
- SemB, FLJ12287, CORD10
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-22
- Date modifiied:
- 2016-01-14
Related products to: SEMA4A antibody
Related articles to: SEMA4A antibody
- The 5' mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5' leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor Analysis Consortium proteogenomic cohorts. Tumor-associated shifts frequently opposed normal tissue aging trajectories, with the clearest signals in lung adenocarcinoma and lung squamous cell carcinoma. Raw closed-uORF burden defined the sharpest paired-supported lung cores, whereas residualized closed-uORF burden provided the most stable length-independent signal. Colon adenocarcinoma reproduced the transcriptomic pattern but showed a prominent adjacent-normal field effect, with nontumor colon already shifted toward the tumor pattern relative to healthy colon. Upstream-initiation features did not improve proteome-wide prediction beyond mRNA abundance but showed modest, gene-selective associations within independently prioritized age-opposed lung gene sets. Recurrent proteogenomic anchors included and . These findings define an age-opposed, tissue-dependent pattern of 5' leader remodeling and prioritize specific genes and isoforms for functional investigation. - Source: PubMed
Publication date: 2026/08/18
Pal AyonPal RanavRoy VivekChaki Madhumita GRoy Bhaskar - Macrophage-associated responses at sites of nerve injury are involved in the initiation and persistence of neuropathic pain (NP). Immune semaphorins (SEMAs), including SEMA3A, SEMA3E, SEMA4A, SEMA4D, and SEMA7A, regulate macrophage migration and activation, but their roles in NP remain unclear. This study aimed to identify immune SEMAs associated with NP by analyzing their serum levels and expression in sensory nerve tissues of patients with NP, and to evaluate the potential effects of SEMA-targeted intervention in a mouse model. - Source: PubMed
Publication date: 2026/08/02
Yoshidomi SatoFujii TakayukiHonda HiroyukiKashu Kaoru YoshidaMiyachi YukinoInoue YukaOgata HidenoriYamasaki RyoIwaki ToruIsobe Noriko - The pathogenesis of multiple sclerosis (MS) remains incompletely elucidated. Semaphorins play an active role in the immune and nervous systems by regulating receptor-mediated adhesion mechanisms. Immunosemaphorins have recently emerged as diagnostic biomarkers or therapeutic targets in MS. - Source: PubMed
Publication date: 2026/07/14
Sarıdaş FurkanAydın BirnurÖzpar RifatKoç Emine RabiaHakyemez BahattinAlkan TülinTuran Ömer Faruk - Semaphorins are a large family of proteins originally identified for their roles in axon guidance during neural development. Recent findings have established the importance of semaphorins members in modulating diverse immune responses of T cells in vitro and in vivo. Class 3 semaphorins, typified by Sema3A, signal through Neuropilin-1 and Plexin-A receptors in an activation-dependent manner, suppressing effector proliferation while promoting regulatory T cell stability and shaping cytokine profiles in autoimmunity and cancer. Sema3E and Sema3F similarly fine-tune host defense and inflammation by directing Th1/Th17 responses or restraining aberrant chemotaxis. Class 4 members, such as Sema4A and Sema4D, engage Plexin-B1, Plexin-D1, and CD72 to deliver both "forward" co-stimulatory and "reverse" signals: they amplify CD4 and CD8 effector functions, support T helper-B cell crosstalk, and influence tumor immunity via receptor shedding and bidirectional signaling. Finally, although less well defined, class 7 Sema7A operates indirectly-through APCs and Tregs-to regulate inflammatory recall responses and Th1/Th17 driven pathology. Together, these semaphorin-mediated pathways underscore a complex, context-dependent network that balances protective immunity against immunopathology, offering novel therapeutic targets in autoimmunity, infection, and cancer. - Source: PubMed
Publication date: 2026/06/07
Ma HeqingGounni Abdelilah SSu Ruey-ChyiKung Sam K P - Osteoarthritis (OA) is a common degenerative disease characterized by the deterioration of articular cartilage, affecting approximately 240 million people worldwide. Low-grade inflammation-particularly the imbalance in macrophage polarization-is a critical factor in osteoarthritis progression. M1-type macrophages exacerbate cartilage destruction by secreting pro-inflammatory factors and matrix-degrading enzymes, while M2-type macrophages promote repair through anti-inflammatory factors. While macrophage polarization changes in OA have been reported, the macrophage subpopulation communication architecture and dominant ligand-receptor axes across dynamic state transitions remain unclear-and that this is what our integrated framework aims to address. - Source: PubMed
Publication date: 2026/06/05
Qiu YueHuang ShuzhongYu BoWei BaochenRen TianyuYang XiaofanShi ZhanyingWei Zhaolan