Ask about this productRelated genes to: SEC61A1 antibody
- Gene:
- SEC61A1 NIH gene
- Name:
- SEC61 translocon alpha 1 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-13
- Date modifiied:
- 2019-04-15
Related products to: SEC61A1 antibody
Related articles to: SEC61A1 antibody
- Severe congenital neutropenia (SCN) is a heterogeneous hematopoietic disorder characterized by impaired granulocyte maturation and increased susceptibility to infections. Over 25 genes have been linked to SCN, yet the molecular pathogenesis remains unknown in 30%-50% of cases. This study aimed to expand the understanding of SEC61A1 variant-mediated diseases. - Source: PubMed
Wang ZixuanJing HuiChen YuhanZhong LingYang Jiyun - Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic disorder characterized by tubular damage and interstitial fibrosis, with inescapable progression to end-stage renal disease. SEC61A1-related ADTKD has long been neglected and underrecognized because of its rarity, insidious onset and variable clinical manifestations. - Source: PubMed
Publication date: 2026/03/16
Zhong LinqingDing JuanMa MingshengWang ChangyanXiao JuanWei MinJian Shan - Aging is the primary cause of cognitive decline. Despite extensive study, the molecular mechanisms driving aging-associated cognitive decline remain unclear. Here, we describe a proteostasis-independent function of SEC61A1 and its involvement in aging-associated cognitive decline. SEC61A1 regulates ER-mitochondria contact sites, affecting mitochondrial DNA and RNA synthesis and subsequently leading to changes in innate immune signaling mediated by mitochondrial double-stranded RNA (mt-dsRNA). This pathway is activated in aged wild-type mice, Alzheimer's disease patients, and 5×FAD mice. Tissue-specific overexpression of Sec61a1 in the mouse cortex (Sec61a1) is sufficient to induce cognitive decline without affecting motor activity. Knockdown of Sec61a1 or Mavs ablates mt-dsRNA-mediated innate immune signaling and alleviates cognitive decline in naturally aging wild-type mice. These results reveal a molecular mechanism of aging- and disease-associated cognitive decline and provide a potential therapeutic tool for intervention. - Source: PubMed
Publication date: 2026/02/16
Zhang LixiaoLi XiangLuo HongdiHuo YujiaZhou GuangkengWang PengchengWu SipengLin XinyongDai KaiShi JiahaoWang ZebaoXu JiaxinLi RenjianChen SiyiSun ZheZhao ChunlinZhou ZizhuoWang ZhenhongLiang ChensiZhu JunChen XingjunLuo JintaoYu YongZhang ZhirongWang Geng - The black rockfish (Sebastes schlegelii), an important species in aquaculture, has experienced significant population declines due to habitat degradation and overfishing. Despite its rapid growth making it attractive for aquaculture, larval rearing remains challenging, as high-density culture conditions frequently lead to skeletal deformities and slowed growth. To elucidate the molecular mechanisms supporting this fast growth and developmental transitions, we profiled transcriptomic changes across three developmental stages (n = 3 per stage): larval (5 days post-hatching, dph), post-larval (21 dph), and juvenile (45 dph). RNA-Seq generated 56.77 Gb of clean data, resulting in 21,837 annotated unigenes. Differential expression analysis (|logFC|≥ 1.2, FDR < 0.05) identified dynamic transcriptomic changes, with 3532 upregulated and 3383 downregulated genes in the 21 vs. 5 dph comparison, and 3789 upregulated and 4582 downregulated genes in the 45 vs. 21 dph comparison. GO enrichment revealed stage-specific pathways, including antigen processing in larvae and autophagy in post-larvae. KEGG pathway analysis underscored notable changes in metabolic processes, including long-term potentiation (21 vs. 5 dph) and proteasome-mediated protein degradation (45 vs. 21 dph). Hub genes, including haao, sec61a1, and vcp, were implicated in energy metabolism, protein synthesis, and cell cycle regulation, supporting rapid growth and tissue differentiation. This study provides fundamental transcriptomic data for exploring early development in S. schlegelii. The identified genes and pathways may facilitate further investigations into growth mechanisms and offer a molecular basis for improving larval survival and aquaculture performance. - Source: PubMed
Publication date: 2025/11/03
Zhang ZhengLi XishanHe TingtingZhang YamingYu ShuangqiaoPu HongyuWang WeiLi Xuejie - Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a common monogenic kidney disease leading to kidney failure usually during mid adulthood. It is due to pathogenic variants in at least five genes. However, despite thorough screening of UMOD, MUC1, REN, HNF1B and SEC61A1, 25 to 50% of families remain without molecular diagnosis. - Source: PubMed
Publication date: 2025/10/06
Menguy LucieHudier LaurentZaidan MohamadKnebelmann BertrandSayer John AArcila-Galvis JulianaArondel ChristelleHummel AurélieDorval GuillaumeMorinière VincentFula-Pitu LandrineGuerrera ChiaraBuob DavidRabeyrin MaudMarijon PierreJean-Marcais NolwenFournier ChloéDuong Van Huyen Jean-PaulAntignac CorinneSaunier SophieHeidet Laurence