Ask about this productRelated genes to: SEC11A antibody
- Gene:
- SEC11A NIH gene
- Name:
- SEC11 homolog A, signal peptidase complex subunit
- Previous symbol:
- SEC11L1
- Synonyms:
- SPC18, sid2895, SPCS4A
- Chromosome:
- 15q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-05
- Date modifiied:
- 2015-07-23
Related products to: SEC11A antibody
Related articles to: SEC11A antibody
- Alternative splicing (AS) significantly increases the diversity of the eukaryotic proteome, and alterations in AS induced by viruses have emerged as a novel approach to studying virus-host interactions. Human metapneumovirus (HMPV) interacts with host cells through multiple mechanisms, directly or indirectly utilising various host systems to facilitate infection and replication. In this study, the BEAS-2B human normal lung epithelial cell line was used as the cell model for HMPV infection. The host gene alternative splicing events following HMPV infection were then characterised using RNA sequencing. Selected alternative splicing events were confirmed and the associated genes evaluated for their effect on HMPV replication in knockout cell lines. HMPV replication was found to be greatly reduced in cells lacking the gene, suggesting that the gene is a critical host factor for HMPV infection. Notably, the splicing pattern was not altered during infection with other respiratory viruses. In summary, this study reveals that , which encodes the core catalytic subunit of the signal peptidase complex (SPC), is an essential host factor for HMPV infection. We observed a specific exon-skipping event in its mRNA precursor that occurs within the regulatory region upstream of the coding sequence. This atypical splicing site suggests that the virus may regulate expression by interfering with the host splicing machinery. These findings provide new insights into HMPV pathogenesis and lay the groundwork for further exploration of HMPV-host interactions and the development of potential host-directed antiviral therapies. - Source: PubMed
Publication date: 2026/01/05
Huang YimanGuo JiayinZheng ShiyuanChen AijunYao LihongZhang KeZheng Lishu - Nanchangmycin is a natural product with broad-spectrum activity against various organisms, exhibiting antibiotic, antiviral, anticancer, and antifibrotic effects. Nanchangmycin belongs to the family of polyether ionophores and is proposed to exert its therapeutic effects by altering ion gradients across biological membranes. Although this therapeutic mechanism has been well characterised in cancer models, it does not fully explain how nanchangmycin inhibits Zika virus infection, as recently reported. The specific molecular targets responsible for mediating nanchangmycin's antiviral activity remain unknown. Here, we designed a photoreactive clickable nanchangmycin probe and employed chemical proteomics to identify protein targets of nanchangmycin related to Zika virus infection in human cells. Among the most prominent targets was the protein SEC11A, a key component of the signal peptidase complex, which is essential for cleaving and processing Zika virus proteins. We showed that nanchangmycin blocks the cleavage of a Zika virus polyprotein, suggesting a novel mechanism for nanchangmycin-mediated inhibition of Zika virus infection. - Source: PubMed
Publication date: 2025/10/21
Leiva SantiagoFreyermuth ChloéClaverol StéphaneMantione DanieleThinon Emmanuelle - Colorectal adenocarcinoma (COAD) is the most common subtype of colorectal cancer. Due to the imperfect prognosis of COAD, related prognostic factors and possible mechanisms need to be further investigated. During tumor development, mitochondria help tumor cells survive in a variety of ways, so that further screening of mitochondrial metabolism related targets has positive implications for COAD. We screened the mitochondrial metabolism-related genes (MMRG) associated with the COAD prognosis and explored the MMRG-related molecular subtype characteristics of by unsupervised consensus clustering analysis. Using ESTIMATE and ssGSEA algorithms, we evaluated the immunoinfiltration characteristic landscape of different molecular subtypes defined by MMRG. Combining the expression profiles of differentially expressed genes associated with the MMRG subgroup and the survival characteristics of COAD, we constructed an MMRG prognostic model using LASSO-univariate Cox analysis and successfully validated its impact on independently predicting risk stratification of COAD. The potential clinical value of the MMRG score was subsequently evaluated by subgroup immunoinfiltration characteristics and drug susceptibility prediction analysis. We also offer SEC11A as a new potential target for COAD by single-cell sequencing analysis. The effect of SEC11A on the proliferation, invasion abilities and mitochondrial dysfunction of COAD cells was confirmed through in vitro experiments. Our study provides new insights into the role of MMRG and new target for COAD potential intervention. - Source: PubMed
Publication date: 2024/10/17
Wang MengXue LingkaiFei ZhenyueLuo LeiZhang KaiGao YuxiLiu XiaoleiLiu Chengkui - [This corrects the article DOI: 10.1016/j.heliyon.2023.e14958.]. - Source: PubMed
Publication date: 2023/05/23
Shen HailongYi FangzhengDing ZhaoLiu WeiweiLiu PingWang ZixiLiu ShixianLiu YehaiLi Dapeng - Head and neck squamous cell carcinoma (HNSCC) is a prevalent disease that has a low survival rate and high recurrence risk. Our study aims to investigate the expression and role of SEC11A in HNSCC. - Source: PubMed
Publication date: 2023/03/28
Shen HailongYi FangzhengDing ZhaoLiu WeiweiLiu PingWang ZixiLiu ShixianLiu YehaiLi Dapeng