Ask about this productRelated genes to: SDHC antibody
- Gene:
- SDHC NIH gene
- Name:
- succinate dehydrogenase complex subunit C
- Previous symbol:
- PGL3
- Synonyms:
- CYB560, cybL
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-21
- Date modifiied:
- 2019-04-23
Related products to: SDHC antibody
Related articles to: SDHC antibody
- Succinate dehydrogenase (SDH) is an enzyme complex that plays a major role in cellular metabolism, as it sits at the interface between carbon metabolism in the Krebs cycle and oxidative phosphorylation for energy production. The precursor and product of the enzymatic reaction, succinate and fumarate, respectively, are regulators of various cellular and biological processes such as epigenetic status, hypoxia responses and angiogenesis, metabolic reprogramming, tumorigenesis, and immune responses. Succinate is considered an oncometabolite, and SDHx genes are tumour suppressor genes. Carriers of germline pathogenic variants (PV) in one of the SDHx genes (SDHA, SDHB, SDHC, SDHD, SDHAF2) carry a life-long risk of developing tumours, predominantly paragangliomas and phaeochromocytomas (PPGL). Research has focused mainly on the disease state in which, in accordance with the Knudson two-hit model, the second allele is inactivated in tumour cells; the biological consequences of which are massive intracellular accumulation of succinate and/or reactive oxygen species (ROS), which in turns leads to tumourigenesis. Little is known about the haplo-insufficient state, in which the wild-type SDHx copy at least partially sustains SDH function and keeps intracellular succinate and ROS levels in ranges that are, if not normal, then at least non-tumourigenic. This review will consolidate the literature regarding genotype differences between SDHx PV carriers, the phenotype of non-tumoral cells in healthy individuals, and the role of environmental factors in influencing tumour development, potentially via tipping succinate (or ROS) levels above a tumourigenic threshold. - Source: PubMed
Publication date: 2026/08/21
Lim Eugenie SBayley Jean-PierreGimenez-Roqueplo Anne-PauleClifton-Bligh Roderick JRichter Susan - Cardiac paragangliomas are rare neoplasms, comprising only 1%-3% of primary cardiac tumours, and often pose a diagnostic challenge. - Source: PubMed
Publication date: 2026/08/13
Bhalla Jaideep SinghSaraswati UshasiBansal AgamAbou Hassan OssamaKlein Allan - Activated sludge-membrane bioreactors (AS-MBRs) are commonly used for liquor wastewater treatment; however, persistent membrane fouling and the challenging removal of refractory organics limit their long-term stability. In this study, simulated liquor wastewater was employed to compare an algal-bacterial granular sludge-membrane bioreactor (ABGS-MBR) with a conventional AS-MBR under different influent carbon conditions. ABGS-MBR achieved its best overall performance in Phase II (nominal C/N = 8), attaining COD, p-cresol, NH-N, TN, and PO-P removals of 93.1 %, 82.1 %, 78.6 %, 65.7 %, and 70.0 %, respectively, together with slower transmembrane pressure development and lower filtration resistance. The improved performance was associated with the integrated characteristics of ABGS-MBR, including stable granular structure, greater microbial genetic potential, and favorable extracellular polymeric substances (EPS) and cake-layer characteristics. Specifically, ABGS-MBR exhibited higher relative abundances of taxa potentially associated with aromatic compound degradation and genes associated with carbon (e.g., glk, sdhC, and aceE), nitrogen (e.g., amoB, hao, and napB), and phosphorus (e.g., ppk1 and ppa) metabolism, indicating greater genetic potential for carbon, nitrogen, and phosphorus transformation. Meanwhile, lower accumulation of loosely bound proteinaceous EPS and weaker protein-like fluorescence were associated with a looser cake-layer structure. This study provides insights into the relationships among microbial genetic potential, EPS characteristics, and membrane fouling behavior in the integrated ABGS-MBR process under different influent carbon conditions for liquor wastewater treatment. - Source: PubMed
Publication date: 2026/08/10
Zhao ZiwenChen XinZhang ZiyangYang XiaojingLuo QijinLi JingshiTang Lan - The SDHC c.397C>T (p.Arg133Ter) germline pathogenic variant is present in over 40% of mutation-positive paragangliomas in French-Canadian patients, supporting a founder effect. We aimed to characterize pheochromocytomas and paragangliomas (PPGLs) associated with this variant in a large international cohort of European descent. - Source: PubMed
Publication date: 2026/08/10
Parisien-La Salle SPerreault FMahrokhian SDumas NCorbeil GLacroix AGimenez-Roqueplo A PVaidya ASt-Jean MBourdeau I - To develop and externally validate a machine learning model for predicting shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid hemorrhage (aSAH) using multimodal dynamic data. - Source: PubMed
Publication date: 2026/07/24
Zheng ChengzhangHuang JianhuangWang XinguoYe QingLin CaihouGu Xiang