Ask about this productRelated genes to: SDHC antibody
- Gene:
- SDHC NIH gene
- Name:
- succinate dehydrogenase complex subunit C
- Previous symbol:
- PGL3
- Synonyms:
- CYB560, cybL
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-21
- Date modifiied:
- 2019-04-23
Related products to: SDHC antibody
Related articles to: SDHC antibody
- Brown rot, caused by , is the most destructive pre- and postharvest fruit rot of peach worldwide. In 2024, a disease outbreak occurred in a South Carolina orchard despite a rigorous chemical management program consisting of preharvest applications of SDHI, QoI, and DMI fungicides. Isolates from affected orchards carried the element upstream of the gene, associated with reduced DMI fungicide sensitivity in the southeastern region. They displayed low, moderate, or high levels of resistance to boscalid, isofetamid, fluopyram, and fluxapyroxad based on EC values ranging from 0.33 to >300, 0.22 to 1.95, 0.28 to 7.41 and 0.30 to 115.11 µg/ml, respectively. In contrast, EC values obtained for historic isolates were ≤ 0.05 µg/ml for all SDHI fungicides. Whole-genome sequencing identified five SDH genotypes: wild type (WT; no aa substitutions); G1 (N226H in SDHB); G2 (P80H in SDHC); G3 (N226H in SDHB + V26I in SDHD); and G4 (N226H in SDHB, P80H in SDHC, and T24A in SDHD). Isolates harboring aa changes in multiple SDH subunits had the highest EC values and were resistant to all SDHIs tested. Detached fruit assays confirmed that label rates of SDHI fungicides failed to control isolates carrying multiple aa changes. To the best of our knowledge, this study provides the first report worldwide of SDHI resistance in species field isolates linked to aa changes in the SDH subunits and combined SDHI and DMI resistance in peach orchards, highlighting the need for resistance monitoring and management. - Source: PubMed
Publication date: 2026/08/26
Gelain JhuliaWesche JohannaTrotter Emma KatherineBeger MatheusOrtiz MaximilianoSchnabel Guido - Genetic testing of patients with pituitary adenomas enables delivery of genotype-based precision care. Germline testing might identify variants predisposing to formation of pituitary adenomas and, potentially, other neoplasms. These include loss-of-function variants in AIP, MEN1, CDKN1B, PRKAR1A, SDHA, SDHB, SDHC, SDHD and MAX; GPR101-containing Xq26.3 microduplications; and postzygotic gain-of-function GNAS variants. Somatic testing might help identify and manage aggressive pituitary adenoma types and very rarely encountered pituitary carcinomas. This Pituitary Society Consensus Statement provides evidence-based guidance on the clinical application of these genetic tests, focusing on germline genetic testing, with recommendations regarding genes for inclusion in panel testing, test indications, pre-test counselling, test methodologies, and the interpretation and follow-up of results. As somatic genetic testing is gradually becoming available in clinical practice, recommendations are provided regarding clinical scenarios in which somatic testing might be considered and which genes to test. The consensus group concluded that genetic testing is an increasingly valuable adjunct in the assessment and management of people with pituitary adenomas. When indicated, genetic testing should ideally be undertaken within a multidisciplinary team comprising endocrine, genetic and laboratory expertise to ensure high-quality testing and safe and effective result interpretation and follow-up. - Source: PubMed
Publication date: 2026/08/25
De Sousa Sunita M CAndoniadou Cynthia LDaly Adrian FGadelha MônicaGatto FedericoKamenický PeterMarques PedroReincke MartinRuf-Zamojski FrederiqueSalvatori RobertoTakahashi YutakaTatsi ChristinaAraki TakakoChiloiro SabrinaDichtel LauraIoachimescu Adriana GMallea-Gil SusanaNiculescu Dan APereira Alberto MShimon IlanWass JohnZada GabrielFleseriu MariaMelmed Shlomo - Succinate dehydrogenase (SDH) is an enzyme complex that plays a major role in cellular metabolism, as it sits at the interface between carbon metabolism in the Krebs cycle and oxidative phosphorylation for energy production. The precursor and product of the enzymatic reaction, succinate and fumarate, respectively, are regulators of various cellular and biological processes, such as epigenetic status, hypoxia responses and angiogenesis, metabolic reprogramming, tumourigenesis, and immune responses. Succinate is considered an oncometabolite, and SDHx genes are tumour suppressor genes. Carriers of germline pathogenic variants (PVs) in one of the SDHx genes (SDHA, SDHB, SDHC, SDHD, SDHAF2) carry a life-long risk of developing tumours, predominantly phaeochromocytomas and paragangliomas (PPGLs). Research has focused mainly on the disease state in which, in accordance with the Knudson two-hit model, the second allele is inactivated in tumour cells; the biological consequences are massive intracellular accumulation of succinate and/or reactive oxygen species (ROS), which in turn leads to tumourigenesis. Little is known about the haploinsufficient state, in which the wild-type SDHx copy at least partially sustains SDH function and keeps intracellular succinate and ROS levels in ranges that are, if not normal, then at least non-tumourigenic. This review will consolidate the literature regarding genotype differences between SDHx PV carriers, the phenotype of non-tumoural cells in healthy individuals, and the role of environmental factors in influencing tumour development, potentially via tipping succinate (or ROS) levels above a tumourigenic threshold. - Source: PubMed
Lim Eugenie SBayley Jean-PierreGimenez-Roqueplo Anne-PauleClifton-Bligh Roderick JRichter Susan - Cardiac paragangliomas are rare neoplasms, comprising only 1%-3% of primary cardiac tumours, and often pose a diagnostic challenge. - Source: PubMed
Publication date: 2026/08/13
Bhalla Jaideep SinghSaraswati UshasiBansal AgamAbou Hassan OssamaKlein Allan - Activated sludge-membrane bioreactors (AS-MBRs) are commonly used for liquor wastewater treatment; however, persistent membrane fouling and the challenging removal of refractory organics limit their long-term stability. In this study, simulated liquor wastewater was employed to compare an algal-bacterial granular sludge-membrane bioreactor (ABGS-MBR) with a conventional AS-MBR under different influent carbon conditions. ABGS-MBR achieved its best overall performance in Phase II (nominal C/N = 8), attaining COD, p-cresol, NH-N, TN, and PO-P removals of 93.1 %, 82.1 %, 78.6 %, 65.7 %, and 70.0 %, respectively, together with slower transmembrane pressure development and lower filtration resistance. The improved performance was associated with the integrated characteristics of ABGS-MBR, including stable granular structure, greater microbial genetic potential, and favorable extracellular polymeric substances (EPS) and cake-layer characteristics. Specifically, ABGS-MBR exhibited higher relative abundances of taxa potentially associated with aromatic compound degradation and genes associated with carbon (e.g., glk, sdhC, and aceE), nitrogen (e.g., amoB, hao, and napB), and phosphorus (e.g., ppk1 and ppa) metabolism, indicating greater genetic potential for carbon, nitrogen, and phosphorus transformation. Meanwhile, lower accumulation of loosely bound proteinaceous EPS and weaker protein-like fluorescence were associated with a looser cake-layer structure. This study provides insights into the relationships among microbial genetic potential, EPS characteristics, and membrane fouling behavior in the integrated ABGS-MBR process under different influent carbon conditions for liquor wastewater treatment. - Source: PubMed
Publication date: 2026/08/10
Zhao ZiwenChen XinZhang ZiyangYang XiaojingLuo QijinLi JingshiTang Lan