Ask about this productRelated genes to: SCO2 antibody
- Gene:
- SCO2 NIH gene
- Name:
- SCO cytochrome c oxidase assembly protein 2
- Previous symbol:
- MYP6
- Synonyms:
- SCO1L
- Chromosome:
- 22q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-12
- Date modifiied:
- 2019-01-21
Related products to: SCO2 antibody
Related articles to: SCO2 antibody
- In this study, we investigated the effect on antioxidant defenses of a tomato extract obtained by supercritical CO extraction (sCOTE), evaluating whether this green extraction method preserves biological activity compared to a conventional tomato extract (CTE) and focusing on superoxide dismutase (SOD) and glutathione peroxidase (GPx) regulation, Nuclear factor erythroid 2-related factor 2 (NRF2) activation, reactive oxygen species (ROS) and lipid peroxidation modulation. - Source: PubMed
Publication date: 2026/05/03
Recalchi SerenaMengoni BeatriceScaglia BarbaraEsposito MarilenaMontalesi EmilianoManganelli ValeriaRiitano GloriaFasciolo ElenaCaglar Tuba RanaCaissutti DanielaMoliterni CamillaArmeli FedericaBusinaro RitaMisasi RobertaSorice MaurizioCapozzi Antonella - Ultra-fast-track extubation (UF) improves postoperative recovery in cardiac surgery, but its cerebral effects remain unclear. This study compared UF and conventional extubation (CE) in children with congenital heart disease (CHD) after cardiopulmonary bypass (CPB), focusing on electroencephalographic (EEG) abnormalities during the initial 48 postoperative hours. Of 352 CHD patients undergoing CPB, 57 UF and 295 CE cases were propensity score-matched (PSM) (1:2), yielding 55 PSM-UF and 89 PSM-CE subjects. Intra/postoperative EEGs were analyzed for background abnormalities (sleep-wake cycle) and epileptiform discharges (seizures, spikes/sharp waves). Clinical parameters including STS-EACTS mortality risk and CPB duration were balanced. The PSM-UF group demonstrated milder background abnormalities (P = 0.02) and lower incidence of unresolved abnormalities at 48 h (7% vs. 24%, P = 0.009). Epileptiform activity was significantly reduced (0% vs. 11% seizures, P = 0.007; P = 0.008 for spikes/sharp waves). UF patients showed superior cerebral oxygen saturation (ScO, P < 0.0001), reduced vasopressor requirements (P < 0.0001), and shorter hospital stays (2.0 ± 1.4 vs. 6.0 ± 5.6 days, P < 0.0001) with comparable CICU stay reductions (9.6 ± 4.1 vs. 13.3 ± 8.5 days, P = 0.002). UF following pediatric cardiac surgery correlates with attenuated EEG abnormalities and enhanced early recovery, supporting its neuroprotective benefits in CHD patients. - Source: PubMed
Publication date: 2026/05/05
Li XiaoweiLin RouyiDu NaFeng JinqingZhou NaNing ShuyaoChen XinxinMa LiZhang MingjieWang HuaizhenLi Jia - Supercritical CO (S-CO) extraction is one of the most employed techniques for the extraction of bioactive compounds for its safety, effectiveness, cost-efficiency, and good environmental compliance. L. (Apiaceae) is an aromatic plant of great interest due to its potential applications in pharmaceutical, agrochemical, and oleochemical fields. Its bioactivity is caused by furanosesquiterpenes, mainly represented by isofuranodiene (IFD). The extraction of this compound is usually achieved through Soxhlet or hydrodistillation. However, the latter usually leads to the thermal Cope rearrangement of IFD into its isomer curzerene, resulting in low recovery. This study reported for the first time the optimization of S-CO extraction of IFD from schizocarps. Pressure (MPa), extraction time (min), and static mode (%) were varied while the temperature was maintained at 45 °C to avoid IFD thermal degradation. The optimized process (50 MPa, 60 min, 25% static mode) provided an extraction yield and an IFD recovery of 8.50 and 0.94% and avoided the thermal degradation of the compound. This study demonstrated that S-CO extraction is a valuable alternative to conventional hydrodistillation (extraction yield and IFD recovery of 2.64 and 0.77%) and Soxhlet (extraction yield and IFD recovery of 9.49 and 0.85%) to recover IFD from . - Source: PubMed
Publication date: 2026/04/03
Spinozzi EleonoraTrebaiocchi GiadaPetrelli RiccardoDi Monaco FrancescoCespi MarcoMaggi Filippo - Tuberculosis (TB) remains a major cause of infectious disease mortality. Early diagnosis is crucial for curbing transmission and initiating timely treatment. However, the lack of reliable non-sputum-based diagnostic tools often delays prompt detection. Since mitochondrial dysregulation facilitates Mycobacterium tuberculosis (MTB) evasion, we explored mitochondria-related gene signatures as diagnostic biomarkers. By integrating microarray (GSE19491) and single-cell RNA sequencing (scRNA-seq; SRP247583) data from active tuberculosis disease (TBD), latent tuberculosis infection (TBI), and healthy controls (HC) obtained from the Gene Expression Omnibus (GEO) database, we identified ten mitochondria-related differentially expressed genes (MitoDEGs) -STAT2, CASP1, SCO2, PRELID1, COX7B, COX6A1, TSPO, IFI6, ATG3, and COX7A2- in the monocytic lineage. Enrichment analysis revealed that these ten MitoDEGs were primarily enriched in oxidative phosphorylation. Quantitative PCR (qPCR) validated the upregulation of these genes in an H37Rv-infected THP-1 cell model (P < 0.01). Using the Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms, we prioritized three hub markers (STAT2, CASP1 and COX7B) to construct a blood-based diagnostic model. The SVM-based model achieved robust diagnostic performance in differentiating TBD in the training (n = 125; AUC = 0.852), validation (n = 30; AUC = 0.885), and two testing sets: GSE54992 (n = 15; AUC = 0.907) and GSE34608 (n = 26; AUC = 0.993). Moreover, an independent clinical cohort further confirmed its efficacy (n = 52; AUC = 0.909) in discriminating TBD from non-TB controls. In summary, we developed a three-MitoDEG model that shows promising diagnostic performance for TBD and was preliminarily validated, offering a scalable, non-sputum alternative for triage in resource-limited settings. - Source: PubMed
Publication date: 2026/04/10
Zhang XianyiZhang KehongWang YuZhang BaozhuHuang ZhenXu Yuzhong - Advanced mining technologies have increased the generation and exposure risk of coal dust nanoparticles (CD-NPs). While CD-NPs are known to cause lung damage, their effects on intestinal tissues following respiratory exposure remain unclear. Here, we investigated the damaging effects of CD-NPs on colonic tissues and the underlying mechanisms. - Source: PubMed
Publication date: 2026/04/02
Zhang YazhenMa YuhanJiang CancanLiu YaoXu YaoYang QiuxueHuang YutingLiu XinkuangZhou ShupingZhang Yinci