Ask about this productRelated genes to: SCMH1 antibody
- Gene:
- SCMH1 NIH gene
- Name:
- Scm polycomb group protein homolog 1
- Previous symbol:
- -
- Synonyms:
- Scml3
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-15
- Date modifiied:
- 2017-07-18
Related products to: SCMH1 antibody
Related articles to: SCMH1 antibody
- Circular RNA (circRNA)-based nucleic acid therapeutics exhibits distinct pharmacological advantages including sustained therapeutic effects from single-dose administration, but the molecular basis governing this persistence remains mechanistically unresolved. Using single-cell RNA sequencing (scRNA-seq), methylated RNA immunoprecipitation sequencing (MeRIP-seq), and genetic animal models, we demonstrated that a single dose of exogenous circSCMH1 sustained elevated endogenous circSCMH1 levels in the peri-infarct region. This persistence stems from a self-sustaining loop initiated by exogenous circSCMH1, as confirmed by experiments with a modified circSCMH1 variant (ΔcircSCMH1), which distinguishes endogenous from exogenous sources. Mechanistically, microglial overexpression of the m6A demethylase FTO enhances circSCMH1 biogenesis by suppressing m6A methylation, with YTHDC1 identified as the primary m6A reader protein facilitating this process. Furthermore, YTHDC1 collaborates with Exportin-4 to mediate m6A-dependent nuclear export of circSCMH1, a step critical for its therapeutic efficacy. In Exportin-4-deficient mice, impaired nuclear export abolishes the sustained brain repair induced by circSCMH1, as evidenced by diminished sensorimotor recovery in behavioural tests. These findings elucidate how a single dose of circSCMH1 improves brain repair through a self-sustaining loop that leverages endogenous circRNA biogenesis machinery. Unlike traditional therapies requiring repeated dosing, this approach achieves prolonged therapeutic efficacy, offering substantial translational advantages for stroke treatment. - Source: PubMed
Publication date: 2026/05/07
Bai YingCai NingboWen LiyingPang LizhiYang YuruiShen LingZhang YuanLuo ZhuojuanChao JieHan BingYao Honghong - Aberrant circular RNA (circRNA) expression is implicated in various diseases, but the regulatory mechanisms remain poorly understood. Our previous work identified circSCMH1 as a brain repair-associated circRNA, prompting investigation into its biogenesis regulation. - Source: PubMed
Publication date: 2026/01/01
Bai YingHan BingZhang YiWen LiyingLiu ChangWang YuCui JiafangZheng BingjingCai NingboXu LianShen LingZhang YuanYao Honghong - Larger body size and enhanced reproductive performance are correlated with increased profitability for sheep farmers. Hu sheep have smaller statures compared to other meat sheep breeds, necessitating improvement. The molecular mechanisms underlying the high fecundity of Hu sheep remain unclear. Body size and reproductive traits are economically important traits in Hu sheep production, necessitating further research. - Source: PubMed
Publication date: 2025/11/10
Li MaoXiang XinGao WeiZhao LiranWang ZhengguangLi Kui - Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate of mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent and nonhuman primate animal stroke models has been found. However, there are still delivery challenges to overcome for its clinical implementation. Besides, its effects on post-stroke cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established to deliver circSCMH1 and explore its therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration of circSCMH1@LNP1 significantly increases circSCMH1 distribution in the peri-infarct region and reduces its non-specific accumulation in other organs compared to intravenous injection. Therapeutic results indicate that circSCMH1@LNP1 promotes synaptic plasticity, vascular repair, neuroinflammation relief, and myelin sheath formation, thereby achieving enhanced sensorimotor and cognitive function recovery in post-stroke mice. In conclusion, this research presents a simple and effective LNP system for efficient delivery of circSCMH1 via intranasal administration to repair post-stroke brain injury. It is envisioned that this study may bridge a crucial gap between basic research and translational application, paving the way for clinical implementation of novel circSCMH1 in post-stroke patient management. - Source: PubMed
Publication date: 2025/03/27
Jia YanpengXu LianLeng ShuoSun YanHuang XinxinWang YuRen HuiLi GuanlongBai YingZhang ZhongkunHan BingShen LingJu MinziChen LehuiYao Honghong - This study investigates the genetic architecture of the Kazakh Whiteheaded (KWH) cattle, applying population genetics approaches to resequenced genomes. analysis of 66 cattle breeds identified breeds for admixture analysis. At K = 19, the composite KWH breed showed contributions from Hereford, Altai, and Kalmyk cattle. Principal component analysis and ancestry inference confirmed these patterns, with KWH genomes comprising 45% Hereford, 30% Altai, and 25% Kalmyk ancestries. Haplotype analysis revealed 73 regions under putative selection in KWH, some shared with Hereford (e.g., with the gene ) and some KWH-specific (e.g., with the gene ). F analysis identified 105 putative intervals under selection, with key genes ( and ) involved in coat colour and physiological adaptations. Functional enrichment using The Database for Annotation, Visualization, and Integrated Discovery (DAVID) in selected regions highlighted clusters associated with developmental processes, ubiquitination, and fatty acid metabolism. Point F identified 42 missense variants in genes enriched in functions related to economically important traits. Local ancestry inference revealed genomic intervals with predominantly non-Hereford ancestry, including high Altai (e.g., ) and Kalmyk (e.g., ) contributions, while Hereford-dominated regions included genes and . This work elucidates the genomic contributions and adaptive signatures of selection shaping the KWH breed, providing candidate genetic variants for breeding program improvement and enhanced genome predictions. - Source: PubMed
Publication date: 2025/01/29
Khamzina Aigerim KIgoshin Alexander VMuslimova Zhadyra UTurgumbekov Asset AKhussainov Damir MYudin Nikolay SUssenbekov Yessengali SLarkin Denis M