Ask about this productRelated genes to: SCAMP1 antibody
- Gene:
- SCAMP1 NIH gene
- Name:
- secretory carrier membrane protein 1
- Previous symbol:
- -
- Synonyms:
- SCAMP37
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-21
- Date modifiied:
- 2018-09-06
Related products to: SCAMP1 antibody
Related articles to: SCAMP1 antibody
- TCOF1 is a nucleolar protein involved in ribosome biogenesis, DNA damage response, and mitotic regulation. Germline mutations are associated with Treacher-Collins syndrome, a rare congenital disorder characterized by craniofacial abnormalities. Clear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer, exhibits pronounced nuclear and nucleolar pleomorphism, which correlates with tumour aggressiveness. The ccRCC grading system relies on microscopic evaluation of nuclear and nucleolar features. Here, we hypothesized that TCOF1 contributes to ccRCC tumorigenesis. - Source: PubMed
Publication date: 2026/03/17
Grzanka MałgorzataPopławski PiotrWiśniewski Jacek RIwanicka-Nowicka RoksanaKossowska HelenaKoblowska MartaRybicka BeataBiałas AlexPiekiełko-Witkowska Agnieszka - Long non-coding RNAs (lncRNA) participate in regulation of gene expression and biology manipulation and altered lncRNA expression associated with cancer development and progression. The lncRNA SCAMP1 expression was aberrant and changed various cancer malignant behaviors. This study assessed SCAMP1 expression in pancreatic ductal adenocarcinoma (PDAC) for association with clinicopathological parameters and survival of patients and then explored the underlying molecular events. The data revealed that SCAMP1 expression was significantly upregulated in PDAC tissues, which was associated with a larger tumor size and tumor de-differentiation as well as poor survival of patients. Knockdown of SCAMP1 expression reduced tumor cell growth, invasion, epithelial‑mesenchymal transition (EMT), and improved sensitivity to 5-fluorouracil (5-FU) in vitro and inhibited tumor cell xenograft growth in nude mice. At gene levels, SCAMP1 was able to target miR-106a-5p to in turn upregulate acylglycerol kinase (AGK) expression and promote PDAC malignant behaviors in vitro. The data from the current study demonstrated an oncogenic SCAMP1 activity in PDAC. Further study will investigate SCAMP1 as a tumor biomarker and novel target in control of PDAC clinically. - Source: PubMed
Publication date: 2025/11/18
Du XiyaoCai YunlongKuang PengZeng MoHuang YingliHuang Shanshan - Exosomes are extracellular vesicles that facilitate communication among cells by exchanging signaling biomolecules with adjacent cells. Among the diverse signaling biomolecules, long noncoding RNAs (lncRNAs) can be selectively packaged into exosomes to influence cancer onset and progression through various mechanisms. This study aimed to explore the role of exosomal lncRNA SCAMP1-AS1 in osteosarcoma (OS). The expression of SCAMP1-AS1 was determined by quantitative reverse-transcription polymerase chain reaction in OS samples, and its role in OS was investigated by performing Cell Counting Kit-8, EdU, and Transwell assays. The characterization of exosomes derived from OS cell lines was conducted by transmission electron microscopyand Western blotting of CD9 and CD81. The effects of exosomes and exosomal SCAMP1-AS1 on OS cells were also evaluated in a series of cell assays. Furthermore, key molecules in the liver kinase B1-adenosine monophosphate-activated protein kinase (LKB1-AMPK) signaling pathway were analyzed by through Western blotting. The results revealed high SCAMP1-AS1 expression in OS, and its silencing in OS cells led to a reduction in cell proliferation, migration, and invasion. The OS cell-derived-exosomes increased the malignant characteristics in the target OS cell lines. Notably, exosomes obtained from OS cells in which SCAMP1-AS1 was silenced effectively counteracted the tumor-promoting effects typically observed with OS-derived exosomes on cocultured target OS cells by activating the LKB1-AMPK signaling pathway. These results demonstrate that exosomal SCAMP1-AS1 serves as a tumor promoter in OS by regulating the LKB1-AMPK signaling pathway. - Source: PubMed
Publication date: 2025/08/12
Li YanxiaZou XiuqiFeng XiaominXia JingWu ZhifengMa Haili - pneumonia (MPP), particularly macrolide-resistant MPP has undergone a prolonged nonseasonal epidemic in China since the lifting of non-pharmaceutical interventions in 2023. This study aimed to identify novel biomarkers to predict disease severity in children with MPP and to develop a predictive model. - Source: PubMed
Publication date: 2025/05/19
Liang AoZhu YaqiWu XiaoxueZhang QingyanHe YafangWang AnbangWu ChunchenXia Jianbo - The treatment options for pancreatic ductal adenocarcinoma (PDAC) remain limited. It is therefore important to explore new therapeutic targets and strategies for better treatment and prognosis for patients with PDAC. NIMA-related kinase 7 (NEK7) is a serine/threonine kinase involved in PDAC development. Moreover, NEK7 was reported to regulate NLRP3 inflammasome and cell pyroptosis. To evaluate the role of NEK7 in PDAC, we performed RNA sequencing analysis in PDAC cells, and a series of bioinformatics analyses were employed to determine the biological function of NEK7 in PDAC. We identified a NEK7-Specific Pyroptosis Gene Set (NEK7-SPGS) by high-throughput transcriptome sequencing combining Gene Set Enrichment Analysis (GSEA). We reveal that NEK7-SPGS is highly associated with T helper cell infiltration and inflammatory response of PDAC. We therefore proposed that NEK7-SPGS might have potential for tumor microenvironment remodeling via T cells induced inflammatory response. Using dataset from TCGA database, we established a NEK7-SPGS-related prognostic signature for patients with PDAC. Subsequently, sensitivity estimation of chemotherapeutic drugs revealed a series of chemotherapy agents according to the NEK7-SPGS-related prognostic signature, including gemcitabine and paclitaxel, drugs that have been used as conventional agents for PDAC therapy. Meanwhile, we showed that the expression of SCAMP1, which is a member of NEK7-SPGS, was involved in the progression of PDAC in vivo and in vitro. We proposed a NEK7-specific pyroptosis gene signature and evaluated its potential in PDAC tumor microenvironment. The NEK7-SPGS-related prognostic signature could act as a prognostic biomarker and serve as therapeutic guidance in clinical application. - Source: PubMed
Publication date: 2025/04/21
Liu JiaYan ZilongZhong TongningQu JianhuaLei DefengLai JinglinZhang CitingLai ZhengquanAi WeipengLiu Xueqing