Ask about this productRelated genes to: RXRG antibody
- Gene:
- RXRG NIH gene
- Name:
- retinoid X receptor gamma
- Previous symbol:
- -
- Synonyms:
- NR2B3
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-14
- Date modifiied:
- 2016-10-05
Related products to: RXRG antibody
Related articles to: RXRG antibody
- Diabetic osteoporosis (DO) is a chronic consequence of diabetes mellitus marked by disrupted bone metabolism and elevated fracture risk, with no effective strategies currently available. Betulinic acid (BA) is a natural pentacyclic triterpenoid demonstrating anti-diabetic, anti-inflammatory, and osteoprotective effects. This research aimed to clarify the molecular mechanisms of BA in DO using network pharmacology, molecular docking, and molecular dynamics simulations. - Source: PubMed
Publication date: 2026/08/06
Sharma SheenamChaudhary RishabhSharma ChiragDabral SwarnaBansal SeemaSharma NeelamGupta Sumeet - Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid proliferation, early dissemination, and limited durable benefit from current chemoimmunotherapy. Although immune checkpoint blockade has modestly improved clinical outcomes, the regulatory logic linking malignant cell states to the tumor immune microenvironment remains incompletely understood. Here, we applied an integrative single-nucleus transcriptomic framework to dissect tumor cell heterogeneity, regulatory programs, and immune-stromal communication networks in SCLC. - Source: PubMed
Publication date: 2026/08/04
Jia HonglingAn YongxuanChen BingZhang YuqiXu YifeiGuan FeilongWu QianSun LiliLi YajingBi JunjieJi XiuliQiu Zhanjun - Intramuscular fat content is a key determinant of pork quality, influencing traits such as tenderness, juiciness, and flavor. However, the molecular mechanisms regulating intramuscular fat deposition in indigenous pig breeds remain incompletely understood. This study aimed to identify genes and regulatory mechanisms associated with intramuscular fat accumulation in Hezuo pigs. Longissimus dorsi muscle samples from Hezuo pigs with extreme high and low intramuscular fat contents were subjected to chromatin accessibility profiling and transcriptome sequencing. Comparative analyses identified 2201 differentially accessible chromatin regions and 588 differentially expressed genes between the two groups. Functional enrichment analyses indicated that these genes were mainly involved in lipid metabolism, focal adhesion, extracellular matrix-receptor interaction, fatty acid metabolism, and adenosine monophosphate-activated protein kinase signaling. Integration of chromatin accessibility and gene expression datasets identified 92 co-regulated genes associated with intramuscular fat deposition, including , , , , , , , , and . These findings reveal regulatory networks underlying intramuscular fat accumulation in Hezuo pigs and provide candidate genes and molecular resources for improving meat quality through genetic selection and breeding programs. - Source: PubMed
Publication date: 2026/07/13
Yang JiaojiaoHuang XiaoyuYang QiaoliLi JieGun Shuangbao - Direct cardiac reprogramming offers a promising strategy to regenerate cardiomyocytes for heart repair, but its efficiency and maturation remain limited. Psoralen, a natural compound isolated from Psoralea corylifolia L., has been widely studied for its bioactive properties. This study aimed to determine whether psoralen enhances chemical cardiac reprogramming and improves functional maturation, and to evaluate its therapeutic potential in myocardial infarction. - Source: PubMed
Publication date: 2026/07/08
Li WenjieLiu HaixiaWan XinyuCheng DingZhang ZhiguoZhu Ruyuan - The contribution of liver sinusoidal endothelial cell (LSEC) zonation to metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis remains undefined. We identified selective lipid deposition in the pericentral zone during early MASLD. Multiomics analyses confirmed enhanced pericentral lipid metabolism in both hepatocytes and LSECs. Mechanistically, pericentral LSEC marker c-Kit transcriptionally activated FGF1 via nuclear receptor RXRG, which suppressed hepatocellular lipid accumulation through FGFR4 signaling. Retinoic acid (RXRG's endogenous ligand and active vitamin A metabolite) phenocopied FGF1's antisteatotic effects. Clinical data revealed an inverse correlation between dietary vitamin A and MASLD severity, suggesting therapeutic potential of vitamin A supplementation for early intervention. - Source: PubMed
Publication date: 2026/06/19
Fang ZhiqiangChe BoLing YuweiLiu PeilinLiu JingjingSong PingYue ZhenshengRuan BaiLin ZhibinXu HaoDu WeiKou ZhifuHe FeiDuan JuanliWang Lin