Ask about this productRelated genes to: RXRB antibody
- Gene:
- RXRB NIH gene
- Name:
- retinoid X receptor beta
- Previous symbol:
- -
- Synonyms:
- NR2B2, H-2RIIBP, RCoR-1
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-14
- Date modifiied:
- 2016-10-05
Related products to: RXRB antibody
Related articles to: RXRB antibody
- Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disease primarily affecting children and adolescents. Reliable biomarkers for diagnosis, disease monitoring, and prediction of disease course are lacking. This study demonstrates that, when compared to healthy participants, the proportion of 'pro-inflammatory' CD14CD16 'classical' monocytes is elevated in patients with CNO, before and after the initiation of treatment. Differential DNA methylation (200 hyper-, 162 hypo-methylated) profiles in monocytes from CNO patients affect key genes involved in immune regulation, including RUNX3, HOXA9, HLA-DMB, HLAB, MAP3K6, RXRB, CD163L1, MAP2, CDK6, HLA-G, HDAC10, and HLA-DQA1 genes. Notably, DNA methylation changes persist and potentially progress over time after the initiation of treatment with naproxen. In conclusion, patients with CNO display higher proportions of 'classical' monocytes when compared to healthy participants in conjunction with dysregulated DNA methylation patterns. Molecular alterations remain despite symptom relief with naproxen, suggesting progressive inflammation-mediated changes. - Source: PubMed
Publication date: 2026/05/15
Carlsson EmilGodoy-Tena GerardMorbach HennerGirschick Hermann JDissanayake DilanCharras AmandineBallestar EstebanHedrich Christian M - Specific gut microbes are critically involved in the development of metabolic diseases, particularly obesity. Here, through analyses of diabetic patients and animal models, we identified Romboutsia ilealis as a novel gut bacterium that alleviates obesity and associated metabolic disorders by suppressing intestinal lipid absorption rather than altering energy expenditure. Metabolomic profiling revealed 2-oxoindole-3-acetate (OAA) as a key mediator of this effect, which was validated both in vitro and in vivo. Mechanistically, biotin-labeled OAA pull-down coupled with proteomics in the intestinal IPEC-J2 cells identified a direct interaction between OAA and the 26S proteasome subunit PSMD3, leading to destabilization of the mA-binding protein YTHDF2. Loss of YTHDF2 derepressed Rxrb mRNA, increasing CD36 and FABP2 expression and thereby promoting intestinal lipid absorption. Together, our findings uncover a previously unrecognized R. ilealis-OAA-PSMD3-YTHDF2-Rxrb signaling axis that links the gut microbiota to host metabolism, and highlight R. ilealis and OAA as potent next-generation probiotic or metabolite-based therapies for obesity. - Source: PubMed
Publication date: 2026/03/17
Zhu LuoyiHuang LiangLiu ShuqiLuo ShiqiLi YigeWang YizhenZong Xin - Cardiac arrhythmias pose a major health concern while the role of antidiabetic medications in cardiac arrhythmic risks is not fully understood. - Source: PubMed
Publication date: 2025/12/04
Song Zheng-QiZhou Zhi-BoWang Bo-XiangWu Sheng-KeSun Yi-HanChen Yi-HeFeng Su-YinSun Run-Feng - Certain types of antidiabetic drugs (ADs) have been proven to improve cognitive functions and symptom dimensions in schizophrenia (SCZ). - Source: PubMed
Publication date: 2025/11/10
Huang Yu-ShengLin XuXu Ya-JuanChen Gui-Bing - Hypersensitivity reactions (HRs) to non-steroidal anti-inflammatory drugs (NSAIDs) constitute a significant clinical concern due to their frequency and possible severity. These reactions may involve specific immunological pathways, including activation of the high-affinity IgE receptor, or non-immunological mechanisms that result in similar clinical manifestations. Additionally, vitamin D plays an important role in the regulation of the immune response and therefore may be relevant to the development or progression of HRs to NSAIDs. - Source: PubMed
Publication date: 2025/10/02
Amo GGarcía-Menaya J MMartí MGómez-Tabales JCornejo-García J ABlanca-López NCanto GDoña IBlanca MTorres M JAgúndez J A GGarcía-Martín EAyuso P