Ask about this productRelated genes to: RTN2 antibody
- Gene:
- RTN2 NIH gene
- Name:
- reticulon 2
- Previous symbol:
- SPG12
- Synonyms:
- NSP2, NSPL1
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-01
- Date modifiied:
- 2016-01-15
Related products to: RTN2 antibody
Related articles to: RTN2 antibody
- Acute myocardial infarction (AMI) is one of the leading causes of mortality worldwide. Despite extensive research, only a limited number of genes have been identified as reliable biomarkers for the diagnosis and treatment of AMI. This study aims to identify novel biomarkers and therapeutic targets for AMI by integrating multi-omics data and machine learning. - Source: PubMed
Publication date: 2026/04/13
Wu JiachengYang YuluHuang JianwuLi XuehanMa QianChen HaoWang YaleiLama ErhaQiu ZhihuaZhou Zihua - Recently, an autoantibody signature considered to be predictive of multiple sclerosis (MS) has been reported in an article by Zamecnik et al. published in Nature Medicine, which is characterized by immunoglobulin G (IgG) responses to peptides sharing the amino acid motif P-(SA)-x-(SGA)-R-(SN)-(LRKH). These results are highly important, all the more so as the same motif is present also in two proteins expressed by Epstein-Barr virus (EBV), a pathogen that likely plays a key role in MS pathogenesis. However, clinically relevant autoantibody responses often target conformational epitopes, and peptides often differ from their corresponding proteins in terms of conformation. We were therefore interested in whether these findings can be reproduced at protein level and may thus play a role also in vivo. Here, we report findings from complementary experiments employing a microarray covering nearly 10,000 human full-length proteins and using serum and cerebrospinal fluid samples from patients with a histopathologically confirmed diagnosis of MS. Our data show that prominent IgG responses to full-length proteins bearing the P-(SA)-x-(SGA)-R-(SN)-(LRKH) motif can indeed be found in a substantial proportion of MS patients, although considerable inter-patient variability exists in both the type and number of individual responses. Notably, these IgG responses were more pronounced in patients with histopathologically defined pattern II MS (which is characterized by intralesional IgG and complement deposition) and pattern III MS than in patients with pattern I MS in our study. New motif-bearing candidate antigens identified in this study include RBMY2FP, CHMP2B, SRSF8 (SFRS2B), NUS1 (NgBR, Nogo-B receptor), and RTN2. Further studies investigating the diagnostic, pathophysiological, therapeutic, and prognostic implications of this antibody signature, as well as the potential role of cross-reactivity with EBV-suggested by the presence of the motif of interest in both EBV BRRF2 and EBV envelope glycoprotein M-are warranted and may significantly advance our understanding of MS. - Source: PubMed
Publication date: 2026/04/08
Jarius SRuprecht KMetz IKönig F BHaas JBrück WPaul FWildemann B - Reticulons (Rtn1p, Rtn2p) and Yop1p are proteins shaping the endoplasmic reticulum (ER) membrane curvature their function being to a large degree responsible for molding the membrane curvature in the tubular ER area. Lipid biosynthesis mainly takes place in the tubular parts of the ER and lipid droplets are formed in the tubular ER membrane. Nucleation constitutes the rate-limiting step in lipid droplet formation and is modulated by membrane curvature; specifically increasing membrane curvature lowers the activation energy required for lipid lens nucleation. The aim of this work was to investigate the effects, modifying the ER membrane curvature would have on lipid droplets in Saccharomyces cerevisiae. - Source: PubMed
Publication date: 2025/11/19
Niemelä Laura R KTunn IsabellFrey Alexander D
- Source: PubMed
- Cutaneous neurotropic melanoma (NM) of the head and neck (H&N) is prone to local relapse, possibly due to difficulties widely excising the tumor. This trial assessed radiation therapy (RT) to the primary site after local excision. - Source: PubMed
Publication date: 2024/06/08
Pinkham Mark BHerschtal AHong A MChua M S-TScolyer R ACumming SPullar ANobes JBarker C AGuadagnolo B AFogarty G BBurmeister B HFoote M C