Ask about this productRelated genes to: RRP8 antibody
- Gene:
- RRP8 NIH gene
- Name:
- ribosomal RNA processing 8
- Previous symbol:
- KIAA0409
- Synonyms:
- NML
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-27
- Date modifiied:
- 2017-06-07
Related products to: RRP8 antibody
Related articles to: RRP8 antibody
- Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant linked to male reproductive toxicity, particularly sperm DNA damage, yet the underlying molecular alterations remain incompletely understood. This study established a mouse model of PFOA exposure (10 mg/kg/day for 8 weeks), which significantly increased the sperm DNA fragmentation index. Integrated transcriptomic and proteomic analyses of testicular tissues identified 4781 differentially expressed genes and 639 differentially expressed proteins, with functional enrichment revealing pathways related to stress response, DNA repair, and metabolism. Four‑quadrant plot analysis pinpointed six molecules (ALDOC, FADS2, PNKD, RRP8, TAF9, and TRAPPC6A) exhibiting concordant dysregulation at both mRNA and protein levels. Mendelian randomization analysis further demonstrated significant genetic associations between these six genes and male infertility in humans. The dysregulation of five of these candidates was subsequently confirmed by qRT-PCR and/or Western blot, with ALDOC, TAF9, and TRAPPC6A showing consistent changes across all experimental approaches. These findings reveal that PFOA‑induced sperm DNA damage is associated with a complex molecular network and prioritize six candidate genes as targets for future functional investigation. This multi‑omics approach provides a comprehensive molecular landscape and offers refined targets for understanding PFOA reproductive toxicity. - Source: PubMed
Publication date: 2026/06/18
Ma SichengMa DongyueSheng JiazhongHao XiaohuiLiu WenbangLiu GuangqiZhang Chenming - To identify m1A-modified genes with diagnostic potential linking periodontitis and type 2 diabetes mellitus (T2DM) by integrating bioinformatics and experimental validation. - Source: PubMed
Publication date: 2025/10/14
Wang KaiWang AiguoQiu LiewangXu LingWei Jingjing - Genome sequencing has revealed that , the etiological agent of histoplasmosis is composed of several phylogenetic species. Nonetheless, the genetic diversity of the pathogen remains largely unknown, especially in the tropics. We sequenced the genome for 91 isolates from the Amazon basin, and used phylogenomics, and population genetic evidence to measure the genetic variation of the genus in South America. We report a previously unidentified clade of endemic to the Amazon basin. The lineage is widespread across the continent and contains five lineages that are sufficiently differentiated to be considered phylogenetic species. We find that the geographic range of these lineages is largely but not completely overlapping. Finally, we find that the patient median age and sex ratio differs among species suggesting differences in the epidemiology of histoplasmosis caused by each lineage. - Source: PubMed
Publication date: 2025/04/03
Ly Tanide Melo Teixeira MarcusJofre-Rodriguez GastonBlanchet DenisMc Donald SigridAlvarado Primaverada Silva Silvia Helena MarquesSepúlveda Victoria EZeb QandeelVreden StephenAdenis AntoineYegres FranciscoDemar MagalieBuitrago Maria José SernaBarker BridgetNacher MathieuMatute Daniel R - N6 methyladenosine (m6A) regulates the ferroptosis in different diseases. However, there is no report about the role of the m6A regulator in the ferroptosis process of septic cardiomyopathy (SCM). This study aims to find the potential m6A regulator that participates in the ferroptosis process of SCM. - Source: PubMed
Publication date: 2024/09/14
Lin WenjiLi HaihongChang JingHuang Yan - Ribosomal RNA Processing 8 (RRP8) is a gene associated with RNA modification and has been implicated in the development of several types of tumors in recent research. Nevertheless, the biological importance of RRP8 in pan-cancer has not yet been thoroughly and comprehensively investigated. - Source: PubMed
Publication date: 2024/09/12
Huang ZhihuiYoo Koo HanLi DuohuiYu QingxinYe LuxiaWei Wuran