Ask about this productRelated genes to: RPS8 antibody
- Gene:
- RPS8 NIH gene
- Name:
- ribosomal protein S8
- Previous symbol:
- -
- Synonyms:
- S8
- Chromosome:
- 1p34.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-20
- Date modifiied:
- 2016-10-05
Related products to: RPS8 antibody
Related articles to: RPS8 antibody
- The genus Sida L. (Malvoideae, Malvaceae) comprises 275 species with a near-cosmopolitan distribution. Persistent taxonomic uncertainties, driven by morphological complexity and low resolution of traditional molecular markers, hinder systematic understanding of the genus. Chloroplast (cp) genomes provide genome-scale data capable of resolving these taxonomic uncertainties, but genomic resources for Sida remain limited. Here, we substantially expand cp genome sampling, perform comparative and selection analyses, identify candidate loci for species discrimination and phylogenetic inference, and conduct phylogenomic inference to clarify infrageneric relationships. - Source: PubMed
Publication date: 2026/06/09
Yan RushanSammad AbdulShah Sayed AfzalVallada AtingaTian XiaoxuanAbdullah - Despite its aggressiveness and unfavorable prognosis, the key molecular drivers of Hepatocellular carcinoma (HCC) are still not fully defined. The role of ribosomal protein S8 (RPS8) in HCC development and its regulatory mechanisms received little attention. We investigated the role of RPS8 in HCC progression by delineating its biological functions, clinical relevance, and mechanistic underpinnings. We conducted comprehensive multi-omics analysis using public datasets (TCGA, GEO) to evaluate RPS8 expression and its prognostic value in HCC. Single-cell RNA-seq was utilized to map the distribution of RPS8 expression within the tumor microenvironment. The biological functions of RPS8 were validated through a series of in vitro assays (e.g., colony formation, Transwell, wound healing) and in vivo subcutaneous xenograft models using RPS8 knockdown and overexpression systems. Whole-transcriptome sequencing was performed to identify the downstream pathways regulated by RPS8. RPS8 was elevated in HCC at both the transcriptional and protein levels, and its overexpression independently signaled poor prognosis. In functional assays, RPS8 increased HCC cell proliferation, migration, and invasion in vitro and stimulated tumor growth in vivo. This pro-tumorigenic activity was associated with the induction of epithelial-mesenchymal transition (EMT) and angiogenesis. Mechanistically, we revealed that RPS8 exerts these effects by activating the endoplasmic reticulum (ER) stress pathway. Furthermore, high RPS8 expression was associated with a remodeled tumor immune microenvironment, characterized by increased CD8+ T cell infiltration. Findings identify RPS8 as a critical oncogene that promotes HCC progression via activation of ER stress. RPS8 can be leveraged as a prognostic biomarker and as a potential focus of therapy in HCC. - Source: PubMed
Zhu LichenLiu HongjiaoQian JinWan SileWen FukaiLi QingyuLu ZhaoyangLiu Jiaming - Osteonecrosis of the femoral head (ONFH) is a progressive condition characterized by bone necrosis, impaired vascularization, and immune dysregulation, often resulting in femoral head collapse. Effective strategies to halt disease progression are limited. Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication and influence osteogenesis, angiogenesis, and immune responses. This review summarizes current evidence on EVs in ONFH and their translational potential. A structured narrative review of PubMed, Scopus, Web of Science, and Cochrane Central databases was conducted, including in vitro, preclinical, and clinical studies on EVs in ONFH. Data on EV sources, molecular cargo, signaling pathways, functional effects, and translational implications were qualitatively synthesized. No pooled statistical analysis was performed because the extracted data were heterogeneous. Bioinformatic analyses such as Gene Ontology, KEGG enrichment, and protein-protein interaction networks were also summarized. In vitro, EVs from bone marrow mesenchymal stem cells, endothelial cells, and M2 macrophages modulate osteogenic differentiation, angiogenesis, and inflammation. Preclinical studies demonstrate that EV administration reduces femoral head necrosis, improves trabecular structure, and enhances neovascularization. Clinical studies have identified EV-associated molecules (SAA1, C4A, RPS8) linked to disease stage and the risk of femoral head collapse. Bioinformatic analyses connect EV cargo to pathways regulating bone formation, vascularization, immunity, and metabolism. EVs appear to play key roles in ONFH pathogenesis and may represent promising candidates for diagnostic and therapeutic applications. However, current clinical evidence remains limited and requires validation in larger studies. Nonetheless, heterogeneity and limited clinical data require standardized, longitudinal studies to validate their translational relevance. - Source: PubMed
Publication date: 2026/04/07
Parrotta Elvira ImmacolataBenedetto Giorgia LuciaCuda GiovanniLongo Umile GiuseppeCarnevale AriannaGalasso OlimpioGasparini GiorgioMercurio Michele - Tulips are economically important ornamental plants that are distributed in Europe, North Africa, and Asia. The Tianshan Mountains are a center of tulip diversity, but there have been few molecular studies of endemic species. In this study, we assembled chloroplast genomes of four species from the Tianshan Mountains: , , , and . The chloroplast genome sequences, including those of and , were collectively analyzed and compared with those of other Liliaceae species. - Source: PubMed
Publication date: 2026/04/01
Ju XiutingShi GuominQin DouwenMa YueHe Tao - Gaining in-depth insights into the interfacial dipole is crucial for optimizing the transfer kinetics of photogenerated electrons at heterojunction interfaces. Herein, we establish interfacial bond polarity as a universal descriptor governing electron transfer kinetics, demonstrated via two model heterojunctions (RP/S and RP/CdS) with identical P-O-S bonds. Density functional theory (DFT) calculation revealed a stronger interfacial dipole in RP/CdS (2.75 D) than in RP/S (1.83 D). Femtosecond transient absorption spectroscopy (fs-TAS) demonstrates a pronounced acceleration of interfacial electron transfer, with RP/CdS exhibiting a rate constant of 5.5 × 10 s, significantly exceeding that of RP/S (2.5 × 10 s). The stronger interface dipole is the key to facilitating the efficient migration of charges. Consistently, the photocatalytic hydrogen evolution (PHE) activities of RP/S and RP/CdS were 1.5-fold and 4.5-fold enhanced compared with their corresponding mechanical mixtures, respectively. This study highlights interfacial dipole engineering as a powerful strategy for the rational design of high-efficiency heterojunction photocatalysts. - Source: PubMed
Publication date: 2026/01/30
Duan YingnanZhao HexiangLi TianhaoJi JixiangFang YuanxingYu Jimmy CShen ZhuruiWang Xinchen