Ask about this productRelated genes to: RPLP0 antibody
- Gene:
- RPLP0 NIH gene
- Name:
- ribosomal protein lateral stalk subunit P0
- Previous symbol:
- -
- Synonyms:
- PRLP0, P0, L10E, RPP0, LP0
- Chromosome:
- 12q24.23
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-16
- Date modifiied:
- 2016-10-05
Related products to: RPLP0 antibody
Related articles to: RPLP0 antibody
- Diffuse large B-cell lymphoma (DLBCL) is a common, aggressive subtype of non-Hodgkin lymphoma with poor outcomes. Identifying the primary molecular causes of DLBCL remains key. The present study examined the function of ribosomal protein lateral stalk subunit P0 () in DLBCL pathogenesis. The Cancer Genome Atlas-DLBCL and GSE12453 datasets overlapping differentially expressed genes were identified. Hub genes were identified via protein-protein interaction network analysis. DLBCL cells were subjected to functional tests following overexpression or knockdown. Reverse transcription-quantitative PCR, western blotting, flow cytometry, transmission electron microscopy, colony formation assay and biochemical analysis were among the tests performed. N-acetylcysteine (NAC), rapamycin (RAPA) and 3-MA were among the medication therapies. In the DLBCL datasets, six ribosome-associated genes were differentially expressed. knockdown inhibited the proliferation of DLBCL cells and caused G-phase arrest, without impacting apoptosis. Thioredoxin, heat shock protein family A member 1A and heat shock protein family B member 1 expression was downregulated by knockdown, which also increased the NAD/NADH ratio, promoted reactive oxygen species (ROS) accumulation and caused mitochondrial membrane potential depolarization. Meanwhile, 3-MA reversed the effects of knockdown, which encouraged LC3-II accumulation, autophagy-related gene 5 () overexpression and an increase in autophagic vesicles. Autophagy-related indicators were decreased, and AKT/mTOR phosphorylation was increased by overexpression, which RAPA inhibited. NAC therapy preserved the viability of -silenced cells, restored p-AKT/p-mTOR levels and restored normal LC3 and ATG5 expression. These findings suggest that regulates stress-induced autophagy through ROS-dependent AKT/mTOR signaling and may represent a potential therapeutic target for DLBCL. - Source: PubMed
Publication date: 2026/08/07
Wang ShanshanYang XutaoMcgowan RochelleHodge BelindaShan DanielMiller NicolasTang Jiahong - RPLP0, a ribosomal protein critical for protein biosynthesis, has emerged as a multifaceted oncoprotein through its regulation of programmed cell death (PCD) pathways. Despite its established roles in tumorigenesis, its pan-cancer relevance and ferroptosis regulatory function remains unexplored. - Source: PubMed
Publication date: 2026/08/11
Wang ZuliChen ShuaiYan BokangPeng XintongChen LingSu MinLi Haiyang - To investigate selected transcripts from urinary cells regarding their potential to predict risk reclassification in patients with prostate cancer (PCa) on active surveillance (AS). - Source: PubMed
Publication date: 2026/08/20
Borkowetz AngelikaGräfe SebastianKwe JeremyFuessel SusanneThomas ChristianErdmann Kati - Glioma ranks among the most intractable malignancies. Given the intricate anatomy of the brain, complete surgical resection is seldom achievable, making radiotherapy a necessary adjunct. Nevertheless, radioresistance, which is closely linked to recurrence, still represents a critical clinical barrier. Effective tumor biomarkers and novel detection methods are urgently required to predict treatment resistance and monitor therapeutic response. Here, we employed surface-enhanced Raman spectroscopy (SERS) coupled with proteomics to profile, for the first time, the characteristic spectral patterns of exosomes secreted by our established radioresistant glioma cells. We further uncovered specific shifts in protein expression during the development of radioresistance, including glycolysis-related proteins (ALDOA and GAPDH) and ribosomal proteins (RPS5 and RPLP0). These proteins are correlated with glioma prognosis. Moreover, bioinformatic analysis revealed that expression levels of all four genes positively correlate with tumor malignancy grade. Furthermore, we established a machine learning-based diagnostic model, Principal component analysis and convolutional neural network (PCA-CNN), for the accurate identification of exosomes derived from radioresistant glioma cells. These findings validate exosomes as a strong candidate biomarker for predicting radioresistance. This approach enables rapid and reliable assessment of radiotherapy resistance in glioma, paving the way for personalized and precise clinical management. - Source: PubMed
Publication date: 2026/07/18
Wu QiongQiu SufangLin DuoLin WanzunWeng Youliang - Clear cell renal cell carcinoma (ccRCC) is characterized by intratumoral heterogeneity and a complex immune microenvironment, which contribute to disease progression and therapeutic resistance. Although ribosomal proteins have been implicated in tumor biology, the clinical relevance, microenvironmental impact, and biological role of ribosomal protein lateral stalk subunit P0 (RPLP0) in ccRCC remain unclear. - Source: PubMed
Publication date: 2026/07/17
Wang BinLiu HongquanGuo YichengMa JianZhang YanweiLi QianZou QingsongWu Jitao