Ask about this productRelated genes to: RPL11 antibody
- Gene:
- RPL11 NIH gene
- Name:
- ribosomal protein L11
- Previous symbol:
- -
- Synonyms:
- L11, uL5
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-23
- Date modifiied:
- 2019-04-23
Related products to: RPL11 antibody
Related articles to: RPL11 antibody
- The innate immune system plays a pivotal role in orchestrating the response to myocardial infarction (MI), with monocytes and macrophages acting as central mediators of tissue injury and repair. Following MI, a dynamic sequence of inflammatory, anti-inflammatory, and reparative phases unfolds over the course of several days. While timely resolution of inflammation and initiation of reparative programs are critical for favorable cardiac remodeling and improved long-term outcomes, the mechanisms by which recruited monocyte-derived macrophages are instructed within the postinfarct niche to adopt a reparative phenotype remain incompletely understood. - Source: PubMed
Publication date: 2026/09/15
Wang ChuhanHan HuianLi KailaiZhang LaiShu ChuanjunCao LiyuanZhang MengxuanYang YatingLiu ShenghangShi HaoLiu ChenBai HuiBen JingjingZhu XudongLi XiaoyuYang QingWang DongdongChen FengZhong YigangWang HaoWang Lian-ShengZhang HanwenChen Qi - Ribosomal protein L11 (RPL11) plays important roles in ribosome biogenesis and stress responses, yet its antiviral function remains poorly understood. This study characterized BmRPL11 and its role in Bombyx mori nucleopolyhedrovirus (BmNPV) infection. BmRPL11 is evolutionarily conserved and shares high sequence homology and protein structure with RPL11 from other species. Tissue expression profiling showed predominant BmRPL11 expression in silk glands and the fat body, with upregulation after BmNPV infection. Functional assays demonstrated that BmRPL11 knockdown enhanced, whereas overexpression suppressed, BmNPV proliferation in BmN cells and silkworm larvae. Mechanistically, BmNPV infection induced nuclear export of BmRPL11 and was associated with enhanced apoptosis, while autophagy-related genes were not markedly affected by BmRPL11 knockdown. IP-MS identified candidate BmRPL11-interacting proteins during infection, including RPL5, whereas a canonical murine double minute 2 (MDM2) homologue was not detected. These findings identify BmRPL11 as an antiviral factor in silkworms, potentially acting through an apoptotic rather than an autophagic pathway. - Source: PubMed
Xia JunmingYu WenshengHuang ZexiangLin JiashengXu ZhenxiangFei ShigangDong XiaoyingSun Jingchen - BYSL gene encodes the bystin-like (BYSL) protein, a nucleolar protein involved in eukaryotic ribosome biogenesis and essential for 40S ribosomal subunit synthesis. Although BYSL upregulation has been implicated in hepatocellular carcinoma, its mechanistic contribution to tumor progression remains undefined. We observed that BYSL is consistently upregulated across multiple cancer types and is associated with adverse clinicopathological features and poor prognosis, with the strongest clinical relevance observed in hepatocellular carcinoma through the integrative transcriptomic and proteomic analyses. BYSL-knockout suppresses malignant phenotypes, including proliferation, migration, and invasion, and induced G1/S arrest and apoptosis. Mechanistically, loss of BYSL disrupts nucleolar homeostasis and reduces global protein synthesis, thereby activating the RPL5/RPL11-MDM2-p53 axis, leading to p53 stabilization and tumor suppression. Importantly, MYC directly bound to the BYSL promoter and transcriptionally activated its expression, whereas co-targeting BYSL and MYC produced more synergistic antitumor effects than either intervention alone. Collectively, our study reveals that BYSL acts as a pivotal downstream mediator of MYC-regulated ribosome biogenesis and promotes hepatocellular carcinoma progression. Our findings suggest that BYSL may represent a potential therapeutic target for hepatocellular carcinoma; nevertheless, additional in vivo preclinical studies are warranted to validate its translational prospects. - Source: PubMed
Publication date: 2026/08/10
Zhao HeyuanLiu HuiyingLiu XiaHe LiangmeiJiang ShupingZhong HaijianKatanaev Vladimir LLi Yumei - Neoporphyra haitanensis and Neopyropia yezoensis are two economically important seaweeds in Asia, yet their germplasm identification is often hindered by high phenotypic plasticity and limited molecular resources. To address this, we utilized a genome skimming strategy on five No. haitanensis and two Ny. yezoensis cultivars to retrieve their plastome information (including whole plastome sequences, plastome-divergent hotspots, and plastome-derived SSRs) and to identify genome-wide polymorphic nuclear SSRs. The plastomes of No. haitanensis (201,110-201,310 bp) were markedly larger than those of Ny. yezoensis (191,974 bp), a difference largely driven by expansions in intergenic regions. Gene annotation identified 253 genes in No. haitanensis and 256 in Ny. yezoensis, with the latter uniquely containing two additional hypothetical ORFs (ORF33 and ORF35) and an extra rRNA gene (rrfB). Further comparative analysis revealed seven hypervariable regions (π > 0.1), five of which-apcE-tatC, psbW-trnR, psbX-accD, trnW-rpl11, and ycf32-rpl32-are intergenic spacers with strong potential as species-discriminatory barcodes. We also characterized 26-30 chloroplast-derived SSRs and identified notable interspecific variations in their repeat-type profiles. Importantly, we developed 230 and 505 high-quality polymorphic nuclear SSRs for No. haitanensis and Ny. yezoensis, respectively, predominantly trinucleotide repeats, offering a robust toolset for fine-scale genetic analyses. Phylogenetic reconstruction using 201 shared plastid protein-coding genes clearly separated the two species into distinct clades, supporting their independent evolutionary trajectories, and further revealed intraspecific genetic differentiation, particularly with the cultivar ZD-1 forming a distinct branch within No. haitanensis. This study provides comprehensive genomic resources-including complete plastomes, hypervariable regions, and polymorphic SSR markers-that will facilitate germplasm identification, phylogenetic studies, and molecular breeding in Porphyra sensu lato. - Source: PubMed
Publication date: 2026/07/20
Zhang CongcongGao ZhicongWang HaotianZhou WeiDeng YinyinYang RuiChen HaiminChen JuanjuanZhu Shanshan - The rising incidence of resistance to conventional chemical insecticides necessitates the development of novel, sustainable pest management strategies. RNA interference (RNAi) offers a highly specific alternative; however, its practical application in lepidopteran pests is often limited by low efficacy due to rapid dsRNA degradation, inefficient transport of dsRNA to the site of action, and suboptimal target gene selection. While nanoformulated dsRNA has been shown to improve RNAi efficiency, delivery enhancement alone does not consistently result in high mortality. In the current study, we used PLL/EGCG/dsRNA nanoformulations to improve RNAi-based control of . We first validated the effectiveness of nanoparticle-mediated RNAi in by targeting the inhibitor of apoptosis (IAP) gene. Nanoformulated dsRNA targeting IAP resulted in substantial gene silencing, with an 80% reduction in target gene mRNA levels and 63% larval mortality, confirming that improved dsRNA delivery can significantly enhance RNAi efficacy in lepidopterans. We extended our analysis to evaluate an additional 14 candidate genes selected from recent genome-wide RNAi screens that identified superior RNAi targets. Orthologs of these genes in S. frugiperda, including proteasome subunit β-type 4 (BT4) and 60S ribosomal protein L11 (RPL11), were targeted using PLL/EGCG/dsRNA nanoformulations. Although these genes induced moderate larval mortality, their effects were consistently lower than those observed with IAP, indicating that IAP remains a more effective RNAi target among the genes evaluated in . - Source: PubMed
Publication date: 2026/06/30
Moola Anil KumarPalli Subba Reddy