Ask about this productRelated genes to: RNMTL1 antibody
- Gene:
- MRM3 NIH gene
- Name:
- mitochondrial rRNA methyltransferase 3
- Previous symbol:
- RNMTL1
- Synonyms:
- FLJ10581, HC90, RMTL1
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-26
- Date modifiied:
- 2016-05-11
Related products to: RNMTL1 antibody
Related articles to: RNMTL1 antibody
- The biological functions of mitochondria play a role in the occurrence and development of breast cancer, however, the causal relationship between them remains unclear. - Source: PubMed
Publication date: 2026/01/26
Liu DongsongXu HongfangYan YanWang BingnanYan Wangjun - More and more studies have shown that mitochondria play a key role in the pathogenesis of sepsis. However, the pathogenesis of sepsis is complex, and there are ethical and implementation challenges in conducting large-scale randomized controlled trials. Mendelian randomization (MR) analysis selects genetic variants as instrumental variables based on genome-wide association studies (GWAS) to infer causal relationships, which can avoid traditional confounding factors. The data of this study were sourced from the IEU OpenGWAS database. The GWAS summary data of 66 mitochondrial functional proteins (MPs) and 5 types of sepsis and their subtypes were included. The "TwoSampleMR" R package was used for analysis. Five methods, including the inverse variance weighted (IVW) method, were used for causal effect analysis. Horizontal pleiotropy and heterogeneity were detected, and sensitivity and reverse association analyses were carried out. The results showed that MICU3, GRPEL1, HTRA2, ISCU, NDUFS4, MCEE, ES1, and LONP1 were protective factors for sepsis, while Grx2, MRM3, and PheRS were risk factors. Among them, MICU3 was strongly correlated with sepsis (28-day death in ICU), and Grx2 was strongly correlated with sepsis (28-day death). This study used 5 MR analysis methods to explore the causal relationships between 66 MPs and 5 types of sepsis and their subtypes for the first time. It was found that some MPs were potential protective factors for sepsis or its subtypes, while some were risk factors. These risk factor MPs may have time-dependent bidirectional effects in the regulation of mitochondrial function in sepsis. This study provides new evidence for elucidating the role of these MPs in the pathophysiology of sepsis, which helps to gain an in-depth understanding of the pathogenesis of sepsis and also lays the foundation for exploring future treatment strategies. - Source: PubMed
Zheng BochaoWang YingdanJi SuhaoLiu Ben - In contrast to N-nitrosamines, little is known about nitrite-induced protein modifications in cured meat products. Therefore, a combined mass spectrometry-based approach involving synthetic tryptic meat peptides and the analysis of cured pork sausages was used to identify these modifications. Model peptides were selected from gently extracted and digested sausage samples according to their abundance, tyrosine content, or position at the protein N-terminus and synthesized. Several deamination products of the peptide N-terminus were described for the first time in peptide model reactions with food-relevant nitrite concentrations, including α-chlorinated, α-phosphorylated and α,β-unsaturated peptides, which may have toxicological relevance due to their electrophilic properties. Tyrosine nitration was detected without an elevated nitrite concentration or the presence of additional oxidants. Furthermore, N-nitrosoproline was identified for the first time in a peptide, and a nitrosoprolyl peptide was also detected in sausages treated with nitrite, even without specific enrichment. Enhanced sensitivity was achieved using MRM mode. - Source: PubMed
Publication date: 2025/06/27
Kempf KarlTajari ElahehBaldermann SusanneJira Wolfgang - Mitochondria are central to immune regulation, inflammation, and cellular metabolism. Growing evidence suggests that mitochondrial dysfunction contributes to autoimmune disease (AD) pathogenesis by modulating inflammatory pathways and immune cell function. However, the causal relationships between mitochondria-related proteins and ADs remain unclear. - Source: PubMed
Publication date: 2025/07/08
Hong Yanggang - Several blood proteins might be associated with the development of colorectal cancer (CRC), but many studies on this topic are often biased. By using genetic variation data, which is less influenced by environmental factors, we can better determine the causal relationship between specific blood proteins and the occurrence of colorectal cancer. - Source: PubMed
Publication date: 2024/11/26
Xu WenjingLi WeiLi YaqiangKuai DayuSun WeiLiu XianXu Baohong