Ask about this productRelated genes to: RNF125 antibody
- Gene:
- RNF125 NIH gene
- Name:
- ring finger protein 125
- Previous symbol:
- -
- Synonyms:
- FLJ20456
- Chromosome:
- 18q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-21
- Date modifiied:
- 2016-06-07
Related products to: RNF125 antibody
Related articles to: RNF125 antibody
- Cervical cancer (CC) is a prevalent malignancy in women; however, the efficacy of immunotherapy in this disease is suboptimal, highlighting the need for novel therapeutic targets. We found that low RNF125 expression correlated with poor prognosis in CC patients. In vitro and in vivo, RNF125 inhibited proliferation and induced apoptosis of CC cells. In immunocompetent mice, RNF125 suppressed tumor growth, increased CD8⁺ T cell infiltration, elevated IFN-γ secretion, and reduced PD-1 expression on CD8⁺ T cells. Co-culture experiments confirmed that tumor cells overexpressing RNF125 enhanced CD8⁺ T cell proliferation and function. Further mechanistic investigation revealed that RNF125 promoted CD8⁺ T cell activity by ubiquitinating and degrading PD-L1. Additionally, RNF125 was identified as a direct target of miR-574-5p. This study demonstrates that RNF125 exhibits tumor-suppressive functions in CC by enhancing anti-tumor immunity, highlighting its therapeutic potential. - Source: PubMed
Publication date: 2026/03/13
Yang DiLiu JiaGao YanGuan XinTong Rui - Activated AKT and YAP signaling have been implicated in the pathogenesis of intrahepatic cholangiocarcinoma (iCCA), but their specific roles in tumor progression and regulation of the tumor microenvironment remain unclear. - Source: PubMed
Publication date: 2026/03/04
Zhao JinqiuYang LianQin YujiaZhang YiWang TingjieWang JingwenLiao RuiGreen BenjaminCui GuofeiLiao WeitingQiao YuXu MengYang HuaFarrar ChristineLiang BingLi XiaosongXin XiaojuanLi XiangCalvisi Diego FWang XueDeng YoupingWu YanhuiChen Xin - Kidney transplant rejection (KTR) poses significant challenges to long-term graft survival, with involvement from ubiquitination-related genes (URGs) in immune modulation. This study aimed to identify key URGs linked to KTR and develop a predictive model for rejection risk. mRNA array data from the Gene Expression Omnibus were analyzed to find differentially expressed genes in GSE98320, which were intersected with URGs to yield 16 DE-URGs. Gene Ontology and KEGG enrichment analysis highlighted the NF-kappa B and TNF signaling pathways. A URGScore model stratified patients and revealed significant differences in immune cell infiltration, especially among Treg cells, demonstrating strong predictive performance in the discovery cohort (AUC = 0.774, 95% CI 0.747–0.800). Six signature genes (,,,,,) were identified, and their expression displayed a subtype-dependent gradient, increasing from antibody-mediated rejection to T cell-mediated rejection and reaching the highest levels in mixed rejection. These genes were incorporated into a nomogram, which achieved an AUC of 0.771 (95% CI 0.745–0.798). Validation in independent datasets confirmed the model’s reliability. In the two transplant rejection cases, and showed higher expression than the other biopsy samples, while generalized high expression of all marker genes was observed in an IgA nephropathy patient. Together, these findings demonstrate the clinical relevance of URG-based biomarkers in KTR and provide molecular insight into immune-mediated rejection. - Source: PubMed
Publication date: 2026/02/10
Shan ZhengfeiYu ShengqiangWang JiantaoCui JianxinWei HaijianFu XiaohuaZhang ChenZhang Chengjun - Non-small cell lung cancer (NSCLC) is the most frequent subclass of lung cancer with a gloomy prognosis. Ring finger protein 125 (RNF125), as a ubiquitin E3 ligase, functions on the progression and development of various tumors. This study attempted to address the function and mechanism of RNF125 in NSCLC. The level of RNF125 was predicted with GEPIA2 website and verified in tumor tissues from NSCLC patients. The role of RNF125 in the malignant processes of NSCLC was determined by cell counting kit-8, the 5-ethynyl-2'-deoxyuridine (EdU) incorporation, transwell, flow cytometry and sphere‑formation experiments. The ubiquitinated role of RNF125 on DEAD-box helicase 5 (DDX5) was assessed by co-immunoprecipitation, ubiquitination and cycloheximide assays. The function of RNF125 was revealed in xenografted mice. Low RNF125 expression predicted poor prognosis in NSCLC. RNF125 inhibited the levels of indexes involved in proliferation, migration, invasion and stemness, but promoted apoptosis rate in both A549 and H1299 cells. Mechanically, RNF125 directly bound to DDX5. Overexpression of RNF125 enhanced the DDX5 ubiquitination, but knockdown of RNF125 reduced the degradation of endogenous DDX5. The inhibitory role of RNF125 overexpression in the malignant progressions of A549 cells was recovered with the upregulation of DDX5, vice versa. Besides, overexpression of RNF125 declined tumor weight and volume, the level of Ki-67 and the numbers of liver metastasis foci in vivo, vice versa. Also, RNF125 overexpression reduced the protein expressions of invasion markers and stemness markers in vivo. Collectively, low expression of RNF125 predicted poor prognosis of NSCLC patients. Upregulation of RNF125 repressed proliferation, mobility, invasion and stemness of NSCLC through the ubiquitinated degradation of DDX5. - Source: PubMed
Publication date: 2026/01/23
Leng XuechunHu ZhongwuZhang MingzhiChen QiuniXu KepingZhao Jun - Sarcomas are heterogeneous mesenchymal tumors with poor responses to systemic therapies. Ubiquitination is a post-translational modification that regulates various physiological processes and cancer growth. - Source: PubMed
Publication date: 2026/01/15
Zhang LinLin WeihaoLiu JinhuiHong YuhengCao ZhengYu ZhentaoFeng XiaoliGao Yibo