Ask about this productRelated genes to: RIBC2 antibody
- Gene:
- RIBC2 NIH gene
- Name:
- RIB43A domain with coiled-coils 2
- Previous symbol:
- C22orf11
- Synonyms:
- DKFZp566F0546, FLJ25720
- Chromosome:
- 22q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-07
- Date modifiied:
- 2019-03-19
Related products to: RIBC2 antibody
Related articles to: RIBC2 antibody
- Early detection of esophageal cancer (EC) remains a major challenge due to the limited understanding of its initial molecular alterations. Therefore, this study aimed to identify the key molecular drivers involved in EC carcinogenesis. Human normal esophageal epithelial cells were subjected to chronic malignant transformation, followed by assessment of their morphological changes, proliferative capacity, clonogenic potential, migration, and invasion abilities. To elucidate the molecular mechanisms underlying tumorigenesis, transcriptome sequencing was performed and integrated with clinical datasets from two independent EC cohorts. Machine learning algorithms were then applied to pinpoint diagnostic and prognostic gene signatures, which were further validated through comprehensive in vitro and in vivo experiments. Differential expression analysis and machine learning identified RIB43A domain with coiled-coils 2 (RIBC2) as a strong diagnostic and prognostic biomarker for EC. RIBC2 expression was markedly upregulated in chronically transformed epithelial cells, established EC cell lines, and clinical tumor specimens, and its elevation was associated with unfavorable clinicopathological characteristics. Functional studies revealed that silencing RIBC2 significantly inhibited cell proliferation, migration, and invasion in both transformed and EC cells. Moreover, immune profiling indicated that high RIBC2 expression was linked to an immune-excluded tumor microenvironment, implying a potential role in modulating responsiveness to immunotherapy. These findings reveal RIBC2 as a novel driver of EC initiation and progression, highlighting its potential as a biomarker for early diagnosis and as a promising target for therapeutic intervention. - Source: PubMed
Publication date: 2026/02/10
Zheng XuanCui YishuangYao XueminWu YananGe YanleiJin YeGan JunqingYao WeinanBi YannaSun Guogui - RIBC1 (RIB43A domain with coiled-coils 1) and RIBC2 (RIB43A domain with coiled-coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo-electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs) localized in the inner lumen of the doublet microtubules (DMTs) in mouse sperm flagella. However, the function of RIBC1 and RIBC2 in mammalian reproduction and sperm flagella is still unknown. - Source: PubMed
Publication date: 2025/04/23
Katsuma KentoShimada KeisukeTonai ShingoMashiko DaisukeIida-Norita RieKaneda YukiMiyata HaruhikoIkawa Masahito - Endometriosis (EMs) is a chronic inflammatory disease characterized by the presence of endometrial tissue in the non-uterine cavity, resulting in dysmenorrhea, pelvic pain, and infertility. Epidemiologic data have suggested the correlation between EMs and recurrent pregnancy loss (RPL), but the pathological mechanism is unclear. This study aims to investigate the potential biomarkers and immune infiltration in EMs and RPL, providing a basis for early detection and treatment of the two diseases. - Source: PubMed
Publication date: 2025/02/03
Chen JianhuiLi QunLiu XiaofangLin FangJing YalingYang JiayanZhao Lianfang - DNA methylation is one of the important epigenetic mechanisms for modulating gene expression. By performing a genome-wide methylation association analysis of whole peripheral blood from 60 Vogt-Koyanagi-Harada disease (VKH) patients and 60 healthy controls, we depicted the global DNA methylation status of VKH disease. Further pyrosequencing validation in 160 patients and 159 controls identified 3 aberrant CpG sites in HLA gene regions including cg04026937 and cg18052547 (located in HLA-DRB1 region), and cg13778567 (HLA-DQA1). We also identified 9 aberrant CpG sites in non-HLA gene regions including cg13979407, cg21075643, cg24290586, cg10135747 and cg22707857 (BTNL2), cg22155039 (NOTCH4), cg02605387 (TNXB), cg06255004 (AGPAT2) and cg18855195 (RIBC2). Increased mRNA levels of BTNL2, NOTCH4 and TNXB were identified in VKH patients when compared with healthy controls, consistent with the hypomethylated CpG status in these gene regions. Moreover, seven aberrantly methylated CpG sites may serve as a diagnostic marker for VKH disease (AUC = 84.95%, 95%CI: 79.49%-90.41%). - Source: PubMed
Publication date: 2023/06/30
Su GuannanDu LipingYu HongsongLi MinghuiHuang RuochengYang XiaonanWang DetaoWang QingYang Peizeng - The pandemic of overweight and obesity (quantified by body mass index (BMI) ≥ 25) has rapidly raised the patient number of non-alcoholic fatty hepatocellular carcinoma (HCC), and several clinical trials have shown that BMI is associated with the prognosis of HCC. However, whether overweight/obesity is an independent prognostic factor is arguable, and the role of overweight/obesity-related metabolisms in the progression of HCC is scarcely known. - Source: PubMed
Publication date: 2023/01/12
Feng Ning-NingDu Xi-YueZhang Yue-ShanJiao Zhi-KaiWu Xiao-HuiYang Bao-Ming