Ask about this productRelated genes to: RHOB antibody
- Gene:
- RHOB NIH gene
- Name:
- ras homolog family member B
- Previous symbol:
- ARH6, ARHB
- Synonyms:
- RhoB, RHOH6, MST081
- Chromosome:
- 2p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-16
- Date modifiied:
- 2016-10-05
Related products to: RHOB antibody
Related articles to: RHOB antibody
- Phosphogypsum (PG) is a major solid by-product generated during wet-process phosphoric acid production. Its stockpiling poses significant environmental risks due to the potential leaching of harmful substances. Therefore, conversion of PG into high-value-added products is urgent. In this work, nano-calcium carbonate (Nano-CaCO) was synthesized from PG via a phase-transfer precipitation method. The surface of the as-prepared product was then modified for Hg detection. Initially, the nanoparticle surface was functionalized with (3-aminopropyl)triethoxysilane (APTES), followed by grafting with a synthesized rhodamine B-based derivative (RhoB-NCS). The acquired product was denoted as CaCO@RhoB-NCS. Physical characterization demonstrated its successful fabrication. The product is an effective sensor for Hg detection, exhibiting enhanced fluorescence emission at 600 nm with a detection limit as low as 1.0 × 10 M. Moreover, the CaCO@RhoB-NCS was used as a filler for Hg test paper. This work demonstrates a promising approach for valorizing solid waste into high-value-added product. - Source: PubMed
Publication date: 2026/08/03
Mo HanLiu QingweiWang NenghaoZhou WentaoSun MingyangWang WuyiHuang XiaoZhang Huali - Primary sclerosing cholangitis (PSC) is a chronic autoimmune cholestatic liver disease characterized by progressive inflammation and fibrosis, but the role of neutrophils in PSC remains poorly understood. To define neutrophil states in the PSC liver microenvironment, we performed single-cell RNA sequencing of leukocytes isolated from liver perfusate obtained from healthy donor grafts and explanted PSC livers. We identified a marked expansion of transcriptionally diverse neutrophil subclusters in PSC liver perfusate. Importantly, PSC livers were enriched for four neutrophil subclusters: RHOB-high, immediate early gene-high, heat shock protein-high, and CXCL8-high liver neutrophil-like subclusters. These PSC-associated neutrophil subclusters showed increased activity of the TNF and IL-17 signaling pathways, consistent with current views of PSC pathogenesis. They also displayed activation of inflammatory transcriptional regulators, including CEBPB, JUN, FOS, and RELA. Pseudotime analysis suggested that RHOB and immediate early gene subsets were derived from immature neutrophils, whereas liver neutrophil-like and heat shock protein-high subsets exhibited more mature and tissue-adapted features. Together, these data reveal previously unrecognized heterogeneity of liver neutrophils in PSC and identify inflammatory neutrophil programs that may contribute to sustained hepatic inflammation and represent potential therapeutic targets. - Source: PubMed
Publication date: 2026/08/11
Zreka LynnMorita HajimeMa ShuheBando ToshiakiKhan MounaMasuo YukiUno ShunsukeSato HirotakaMatsuyama JoeyOkumura ShinyaIto TakashiHatano EtsuroAlshemali SuzanneYoshitomi HiroyukiUeno Hideki - This study focuses on exploring the co-morbid mechanisms by which Bisphenol A (BPA) induces non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA). - Source: PubMed
Publication date: 2026/07/20
Di JingkaiWang ShuangGuo ZijianDi YijingYang NanJuma TalanteLong YinqiQi LikunCao YongpingXiang Chuan - The objective of this study is to explore the expression patterns of angiogenesis-related genes in papillary thyroid cancer (PTC) to enhance understanding of the molecular mechanisms underlying angiogenesis in this malignancy. The findings provide valuable insights into the development of therapeutic strategies. - Source: PubMed
Publication date: 2026/07/19
Zhao JunQin Ya-XinZhao MinNiu HuiLiu Xiao-Qi - Intraocular pressure (IOP), a major risk factor for glaucoma, follows a circadian rhythm with nocturnal increases driven by norepinephrine (NE) from the superior cervical ganglion. This rhythm depends on aqueous humor (AH) dynamics, particularly the outflow through the trabecular meshwork (TM). Herein, we investigated its underlying regulatory mechanisms in the TM because disruption of IOP rhythm increases the risk of glaucoma. Comprehensive gene expression analysis of human TM cells and mouse eyes uncovered NE-upregulated 18 genes, including the small GTPase RHOB. Promoter assays revealed that RHOB is regulated via a cAMP-responsive element. RHOB deficiency enhanced TM phagocytosis and reversed NE-induced suppression of permeability, whereas RHOB overexpression had the opposite effect. In mice, RHO and ROCK inhibitors reduced both nocturnal and NE-induced IOP elevations. These findings suggest that NE elevates IOP by inhibiting TM phagocytosis via RHOB, identifying RHOB as a key regulator of IOP rhythm and a potential target for glaucoma treatment. - Source: PubMed
Publication date: 2026/07/16
Ikegami KeisukeTakahashi TakumiKatamoto YutoOishi AtsuroYoshimi AkihideNagase MikiMiki AtsuyaYasuo ShinobuMasubuchi Satoru