Ask about this productRelated genes to: REG4 antibody
- Gene:
- REG4 NIH gene
- Name:
- regenerating family member 4
- Previous symbol:
- -
- Synonyms:
- REG-IV, RELP, GISP
- Chromosome:
- 1p12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-08
- Date modifiied:
- 2016-10-05
Related products to: REG4 antibody
Related articles to: REG4 antibody
- Antimicrobial resistance (AMR) is a major global health challenge requiring integrated One Health approaches that consider human, animal, and environmental dimensions. In the province of Québec (Canada), a 2019 regulation restricting the use of category I antimicrobials (AMs) in livestock highlights the need for context-specific, evidence-based interventions to limit the dissemination of resistant microorganisms while preserving animal health and production efficiency. In this study, we developed a participatory Multi-Criteria Decision Analysis (MCDA) model to identify and prioritize future interventions aimed at limiting the dissemination of AMR from dairy herds in Québec. The model was co-constructed with stakeholders from agricultural, veterinary, public health, and consumer sectors, encompassing 22 interventions and 18 evaluation criteria covering public health, animal welfare, environmental, economic, social, and operational dimensions. Stakeholders assigned weights to each criterion under three exploratory AMR scenarios representing different risk contexts: (1) the current AMR situation (CURRENT scenario), (2) a scenario depicting an increase in AMR infections in humans (PUBLIC THREAT scenario), and (3) a scenario depicting an increase in AMR infections in dairy cattle (ANIMAL THREAT scenario). Interventions were evaluated through a literature review and expert elicitation, and sensitivity analyses were performed to assess robustness. Across all scenarios, the highest-ranked interventions included producer education (mandatory farm training, EDU1), financial support for preventive veterinary activities (subsidies for preventive monitoring, PRE2), and disease surveillance (mandatory disease surveillance, SUR5). In contrast, restrictive regulatory interventions on AMs sales (REG4, REG5) ranked lowest due to limited feasibility and acceptability. The participatory approach fostered transparency, cross-sectoral dialogue, and consensus-building, demonstrating how MCDA can operationalize the One Health framework for AMR governance. While context-specific, this framework provides a foundation for the development of similar models in other contexts, enabling adaptation to diverse livestock sectors and regional priorities. - Source: PubMed
Publication date: 2026/03/26
Millar NikkyDufour Simonde Lagarde MaudArango-Sabogal J CRoy Jean-PhilippeBelloc CatherineAenishaenslin Cécile - A blood-based test capable of predicting progression to active tuberculosis (TB) before symptom onset could reduce numbers needed to treat and mitigate disease transmission. This study evaluated plasma protein as predictors of TB progression within a cohort of close contacts from a university TB outbreak. Plasma from 17 progressors who developed TB within 2 years, 28 interferon-gamma release assay (IGRA)-positive non-progressors, and 33 IGRA-negative healthy controls was profiled using the Olink proteomics platform. Progressors showed broad downregulation of proteins related to immune regulation, cell adhesion, and nucleotide metabolism, while no significant differences were observed between non-progressors and healthy controls. A six-protein panel comprising LRP11, REG4, FLT3LG, CCDC80, ADA, and DPP7 discriminated progressors from others with AUCs exceeding 0.85. Transcriptomic validation in two independent cohorts support consistent downregulation of these markers. These findings highlight a distinct protein signature with potential for risk differentiation of TB progression and inform the development of targeted preventive strategies. - Source: PubMed
Publication date: 2026/02/20
Han YutongShao YanLiu QiaoZhu LimeiChen ChengXu Biao - This study leverages machine learning and cytokine profiles to differentiate liver and renal function abnormalities in the aging population, aiming for advancements in early detection techniques. - Source: PubMed
Publication date: 2026/02/06
Zeng LvtaoZhang LiLi SijiaWang ZihuiHu JihongLiu HongleiCai Jianping - The detection rate of early-stage gastric cancer remains relatively low. Early detection is beneficial for improving prognosis. We aim to explore the risk factors for lymph node metastasis(LNM) in elderly patients with early gastric cancer (EGC), and to construct a nomogram prediction model for validation. - Source: PubMed
Publication date: 2026/01/30
Liang YufeiTian LiangWang LiangJiang Xiaojia - The pathways linking lipoprotein(a) (Lp[a]) to atherosclerotic cardiovascular disease (ASCVD) are unclear. This study aimed to discover Lp(a)-associated plasma proteins and estimate their associations with incident ASCVD. - Source: PubMed
Publication date: 2025/12/17
Bellomo Tiffany RSaadatagah SeyedmohammadLee JiwooBramel Emily EAbushamat LaylaMisra AnikaNakao TetsushiKoyama SatoshiPatel Aniruddh PUrbut SarahBallantyne Christie MpNatarajan Pradeep