Ask about this productRelated genes to: REG4 antibody
- Gene:
- REG4 NIH gene
- Name:
- regenerating family member 4
- Previous symbol:
- -
- Synonyms:
- REG-IV, RELP, GISP
- Chromosome:
- 1p12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-08
- Date modifiied:
- 2016-10-05
Related products to: REG4 antibody
Related articles to: REG4 antibody
- Early detection biomarkers are needed to support the timely detection and monitoring of ulcerative colitis (UC) and its potential association with colorectal cancer (CRC). We used Data-Independent Acquisition (DIA) proteomics on paired colorectal tissue and exudate samples to define the pathway changes and identify serum-accessible markers. - Source: PubMed
Publication date: 2026/08/05
Gong QianWang JinKe QingDu ShuangshuangHuang SinianZhu TingQu HaoXu RanZhang JiandongYan BinWang Jinjin - Regenerating islet-derived type 4 (REG4) is highly expressed in various cancers, including colorectal cancer (CRC). REG4 has been reported to promote cancer cell proliferation, contribute to treatment resistance, and be associated with poor prognosis in CRC. In humans, this protein has two isoforms that are translated from three RNA-splicing variants. However, previous studies have primarily focused on isoform 1 and have not examined the function of isoform 2. Therefore, in the present study, we aimed to investigate the effects of REG4 isoform 2 on colon cancer cell proliferation. Real-time polymerase chain reaction (RT-qPCR) revealed higher REG4 isoform 2 expression in colon cancer cell lines (DLD-1, HCT116, and HT29) than in normal tissue-derived cell lines (HDLECs, HME1, HUVECs, and TIG114), similar to that of REG4 isoform 1. Moreover, REG4 isoform 2 overexpression significantly enhanced the proliferation of colon cancer-derived HCT116 cells in a WST-1 assay under low-serum conditions and in a soft agar colony formation assay. In NOD/SCID mice, tumor volumes tended to be larger in the REG4 isoform 2-overexpressing group than in the controls, although the difference did not reach statistical significance. Furthermore, in a subset of patients, the expression of this isoform in CRC tissues was higher than that in the adjacent normal tissues in human specimens. These results suggest that REG4 isoform 2, similar to isoform 1, is associated with enhanced proliferative properties of colon cancer cells and highlight the need for further investigation of isoform 2 in future studies. - Source: PubMed
Publication date: 2026/07/03
Kobari AyaKoide HiroshiIshihara HarunaSugimoto KiichiTakahashi MakotoSakamoto Kazuhiro - Pancreatic ductal adenocarcinoma (PDAC) in patients with diabetes mellitus (DM) represents a clinically heterogeneous subgroup, yet biomarkers that reflect diabetes-associated tumor biology and chemotherapy response remain limited. In particular, the influence of diabetes duration on treatment resistance in PDAC is poorly understood. - Source: PubMed
Publication date: 2026/07/02
Choi Jae-IlPark Hee JungPark HakCho YonggeunShin Hyo ShikKoh Young IkLee See YoungJang Sung IllCho Jae HeeKim Hyung SunHwang Ho KyoungRim John HoonLim Jong-Baeck - Elevated monocyte counts predict cardiovascular disease (CVD) risk, but whether this inflammatory risk is modifiable by dietary patterns remains unknown. We investigated whether dietary quality modifies the association between peripheral monocyte counts and incident CVD and explored potential proteomic mechanisms. - Source: PubMed
Publication date: 2026/05/26
Lin XueguangXie ShishuaiSun QiDeng YingTang JingdongZhang HuiYu BoJiang Shuai - Antimicrobial resistance (AMR) is a major global health challenge requiring integrated One Health approaches that consider human, animal, and environmental dimensions. In the province of Québec (Canada), a 2019 regulation restricting the use of category I antimicrobials (AMs) in livestock highlights the need for context-specific, evidence-based interventions to limit the dissemination of resistant microorganisms while preserving animal health and production efficiency. In this study, we developed a participatory Multi-Criteria Decision Analysis (MCDA) model to identify and prioritize future interventions aimed at limiting the dissemination of AMR from dairy herds in Québec. The model was co-constructed with stakeholders from agricultural, veterinary, public health, and consumer sectors, encompassing 22 interventions and 18 evaluation criteria covering public health, animal welfare, environmental, economic, social, and operational dimensions. Stakeholders assigned weights to each criterion under three exploratory AMR scenarios representing different risk contexts: (1) the current AMR situation (CURRENT scenario), (2) a scenario depicting an increase in AMR infections in humans (PUBLIC THREAT scenario), and (3) a scenario depicting an increase in AMR infections in dairy cattle (ANIMAL THREAT scenario). Interventions were evaluated through a literature review and expert elicitation, and sensitivity analyses were performed to assess robustness. Across all scenarios, the highest-ranked interventions included producer education (mandatory farm training, EDU1), financial support for preventive veterinary activities (subsidies for preventive monitoring, PRE2), and disease surveillance (mandatory disease surveillance, SUR5). In contrast, restrictive regulatory interventions on AMs sales (REG4, REG5) ranked lowest due to limited feasibility and acceptability. The participatory approach fostered transparency, cross-sectoral dialogue, and consensus-building, demonstrating how MCDA can operationalize the One Health framework for AMR governance. While context-specific, this framework provides a foundation for the development of similar models in other contexts, enabling adaptation to diverse livestock sectors and regional priorities. - Source: PubMed
Publication date: 2026/03/26
Millar NikkyDufour Simonde Lagarde MaudArango-Sabogal J CRoy Jean-PhilippeBelloc CatherineAenishaenslin Cécile