Ask about this productRelated genes to: RECK antibody
- Gene:
- RECK NIH gene
- Name:
- reversion inducing cysteine rich protein with kazal motifs
- Previous symbol:
- ST15
- Synonyms:
- hRECK
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-30
- Date modifiied:
- 2016-01-28
Related products to: RECK antibody
Related articles to: RECK antibody
- The progression of pancreatic adenocarcinoma (PAAD) is closely linked to autophagy and microRNA (miRNA) regulation. Therefore, constructing miRNA regulatory networks based on PAAD autophagy-related genes is essential for improving targeted therapy. - Source: PubMed
Publication date: 2026/05/14
Chen HongxiSong ShengleiLi ChenglongYu Zhige - Dexamethasone is a glucocorticoid analogue and acts like the hormone cortisol, which is secreted from the adrenal glands. Its prolonged use may alter glucose metabolism. This review is a detailed summary of the underlying molecular mechanism of dexamethasone induced Insulin Resistance and Diabetes Mellitus. A decade of review journals retrieved from Scopus, ScienceDirect, PubMed, and Web of Science databases are systematically analyzed to examine various mechanisms involved in dexamethasone-induced metabolic syndrome. This in vivo model is suitable for studying Diabetes. Impaired insulin sensitivity is a biological response to insulin stimulation in target tissues. This review describes the underlying Dexamethasone-induced Insulin Resistance through multiple molecular mechanisms including decreased expression of glucose transporter protein 1 and 2 (GLUT 1and GLUT 2), glycogen synthase, increased expression of FK506 binding protein 5 (FKBP5), Cx36 protein, GSK-3, altered metabolism, and GLUT 4 transporter expression, mitochondrial dysfunction, defective glucose uptake, inflammation, insulin receptor mutations, stimulation of protein kinase C, oxygen species induced stress, protein folding stress, endothelial dysfunction, suppression of phosphatidylinositol 3 kinase (P13K) activity associated with IRS-1. Significant metabolic alterations triggered by dexamethasone treatment interposed with typical blood sugar homeostasis. Future research should concentrate on methods to avoid insulin resistance caused by dexamethasone without compromising the pharmacotherapeutic effect. Living with insulin resistance in the long run can lead to type 2 diabetes along with other complications. In discriminate use of Dexamethasone is the culprit behind the development of abnormal insulin action. Overall, a better insight in this regard is the need of the hour. Furthermore, work is essential towards the development of new molecules to provide a better substitute in the Reck. - Source: PubMed
Publication date: 2026/05/07
Tripathy BimalaPanda Krishna ChandraMurmu Bikash RanjanKumar B V V RaviAcharjya Sasmita KumariDas Rajaram - Combining treatments with different mechanisms may improve immunosurveillance and outcomes in advanced/recurrent non-small cell lung cancer (NSCLC) after immunotherapy. ENTRÉE Lung (NCT03739710) is a phase 2, open-label platform trial utilizing a master protocol to investigate novel regimens versus standard of care (SoC) in separate sub-studies. Sub-study 1 investigated the immunoglobulin G4 inducible T-cell costimulator agonist antibody, feladilimab, plus docetaxel versus SoC, docetaxel monotherapy. - Source: PubMed
Publication date: 2026/04/08
Garassino Marina ChiaraCousin SophieBesse BenjaminSacher AdrianOrlov SergeySchenker MichaelFelip EnriquetaGladkov OlegMessina Cristina HMajumdar AntaraWu Zhenhua JeremyKarpinich Natalie OHirschfeld StevenBallas MarcReck Martin - Modern patient-centered rehabilitation for critically ill patients focuses on physical, cognitive, psychological, and social recovery to reduce long-term impairments after critical illness. Core strategies include the ABCDEF (A2F) bundle/ICU Liberation, humanization programs, and symptom management. Based on the capabilities of individual patients, frequent assessments in these dimensions are performed to develop person-centered goals and interventions. Early mobilization, cognitive stimulation, delirium prevention and nonpharmacological management, empathic communication, ICU diaries, and family involvement should begin within 24 to 72 hours after ICU admission. The dosage and delivery of these interventions should be adapted to the capabilities and needs of individual patients. - Source: PubMed
Publication date: 2026/03/11
Nydahl PeterEggmann SabrinaEwens BevJones ChristinaKarnatovskaia Lioudmila VNeedham Dale M - The control of the cattle tick, Rhipicephalus (Boophilus) microplus, is an ongoing challenge for cattle producers in tropical and sub-tropical regions around the world. It is a robust parasite that transmits potentially fatal pathogens and can cause substantial damage to cattle in its own right. With a high fecundity and a life cycle with an off-host, free-living phase that can extend to around one year, R. microplus has a demonstrated capacity to both, evade treatment with acaricides and to acquire resistance to acaricides. The aim of this article is to design current best practice recommendations for control of R. microplus for Latin American environments, based on empirical and theoretical studies available in the literature, and on the field experiences of the authors. To help control program designers ensure that all critical factors are considered, a five-pointed approach to control is recommended: (1) Treat with the right product; (2) Treat using the right dose; (3) Treat the right animals; (4) Treat at the right time; (5) Use non-acaricidal methods. Consideration of each of these points should enable control of ticks consistent with three pillars of sustainable parasite control: (1) ensuring environmental and human safety; (2) enhancing the production of high-quality, high welfare animal products; and (3) preserving the financial viability of cattle farms. - Source: PubMed
Publication date: 2026/05/05
Sabatini G ABorges F ACosta-Junior L MCuore UCutolo A AFiel C AJonsson N NLopes W D ZLópez-Osorio SMartins J RMolento MMonteiro C M OMorel NNava SParodi PPulido MReck JRodrigues D SRodriguez-Vivas R I