Ask about this productRelated genes to: RDH12 antibody
- Gene:
- RDH12 NIH gene
- Name:
- retinol dehydrogenase 12
- Previous symbol:
- -
- Synonyms:
- FLJ30273, SDR7C2, LCA13, RP53
- Chromosome:
- 14q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-11
- Date modifiied:
- 2018-02-09
Related products to: RDH12 antibody
Related articles to: RDH12 antibody
- Stomach adenocarcinoma (STAD) poses a significant global health burden, with notable geographic variations in its incidence and complex underlying causes. Palmitoylation plays a crucial role in cancer development, yet its prognostic relevance in STAD remains poorly understood. Multi-omics data integration was performed using TCGA-STAD (N=407) and GEO-GSE26901 (N=110) cohorts with single-cell data (GSE167297; N=14 samples). Palmitoylation-related genes (PRGs=3,599) from GeneCards underwent differential expression screening and Cox regression to identify prognostic DEPRGs. A LASSO-multivariate Cox model constructed a 5-gene signature for risk stratification, validated externally. Comprehensive analyses included molecular subtyping (ConsensusClusterPlus), immune infiltration (CIBERSORT/ssGSEA), immunotherapy response (TIDE/IPS), drug sensitivity (pRRophetic/CellMiner), pathway enrichment (GSEA/clusterProfiler), and single-cell ecosystem characterization. Based on multi-omics analysis of STAD, we identified 5 signature gene (GAMT, RDH12, RNASE1, SERPINE1, and SLC52A3) to construct a robust prognostic model. High-risk group exhibited enrichment in pro-metastatic pathways (CAMs, ECM-receptor interaction) and an immunosuppressive microenvironment (increased M2 macrophages, decreased CD8⁺ T cells), correlating with poor survival, higher TIDE scores, and immunotherapy resistance. Consensus clustering revealed two molecular subtypes with divergent survival outcomes. Single-cell analysis revealed SERPINE1⁺ endothelial cells as a high-risk subpopulation driving angiogenesis via MK pathway interactions with epithelial/stromal cells. Based on multi-omics integration, this study establishes PRGs signature as a robust prognostic biomarker for STAD, enabling risk stratification, molecular subtyping, and prediction of immunotherapy response while elucidating PRGs-mediated remodeling of the tumor-immune microenvironment. - Source: PubMed
Publication date: 2026/06/26
Leng ZerenZhang Wenzhe - The mammalian pineal gland maintains normal circadian rhythms and homeostasis by secreting melatonin. However, the lack of a single-cell-resolved regulatory map limits our understanding of how these neuroendocrine functions are orchestrated. Here, we constructed a multiomics atlas of the pineal gland from by integrating snRNA-seq, snATAC-seq, and spatial transcriptomics. We identified pinealocytes as the predominant cell type, alongside six glial and vascular lineages. Chromatin accessibility analysis delineated cell-type-specific regions enriched for melatonin synthesis and phototransduction genes. Notably, we resolved a dual-layer regulatory architecture: While melatonin synthesis programs are robustly organized, circadian clock regulators exhibit a distinct, sparse spatial pattern. Coexpression networks further identified core modules and regulatory hubs-including CRX/OTX2, LHX4, and RORA-that integrate these circadian and light-responsive signals. Cell-cell communication analysis identified signaling axes, such as -/, -, and -, that potentially coordinate this spatial functional organization. Integrating genetic traits showed that sleep and neuropsychiatric risk variants preferentially map to these pineal regulatory modules. Specifically, sleep-associated loci converged on -linked elements, while bipolar disorder-associated loci highlighted candidate genes of and . Overall, this study reveals the cellular diversity and spatial regulatory logic of the primate pineal gland, providing a physiological foundation for investigating circadian and neuroendocrine regulation in healthy and disease models. - Source: PubMed
Publication date: 2026/05/05
Zheng JihongXiao YuchenLyu JianjunXu HongtaoZhang YaqunLi YanchuanLi YihaoWang TianjunLiu LiuJin LingjingZhou XuhuiZhang Chao - The RDH12 gene encodes a retinal dehydrogenase enzyme critical for visual pigment regeneration. Peripheral blood mononuclear cells (PBMCs) were isolated from a 28-year-old patient harboring a homozygous nonsense mutation c.193C > T, p.R65X in RDH12. These cells were reprogrammed into an induced pluripotent stem cell (iPSC) line using episomal plasmids expressing the human reprogramming factors OCT4, SOX2, NANOG, LIN28, KLF4, and L-MYC. The established iPSC line demonstrated a normal karyotype, expressed canonical pluripotency markers, and possessed the capacity to differentiate into derivatives of all three germ layers in vitro. - Source: PubMed
Publication date: 2026/04/15
Yu Si-JianJin Zi-BingLiu Wu - Inherited retinal dystrophies (IRDs) are a leading cause of visual impairment and irreversible blindness worldwide, yet their precise molecular and genetic mechanisms remain unclear. N-1ent. In the mammalian retina, mA methylation is widely distributed in various cellular layers and is essential for retinal homeostasis. In this study, we assessed the in vivo roles of WTAP, a crucial component of the mA methyltransferase complex, in the mammalian retina and demonstrated that loss of Wtap led to diminished scotopic ERG responses, progressive retinal degeneration, and significant loss of rod cells in mice. Wtap deficiency drastically reduced global mA levels in the retina due to abolished WTAP-mediated stability of the methyltransferase complex. Mechanistically, absence of WTAP disrupts mA modification of phototransduction-related genes and specifically causes the epigenetic silencing of PDE6B, REEP6, and RDH12. Detailed analysis further revealed that WTAP facilitated the translation of Reep6, Pde6b, and Rdh12 through modulating mA deposition in 3'UTR of mRNAs. Moreover, reintroduction of WTAP in affected retinas, through crossing with CAG-Wtap mouse line or AAV-mediated gene therapy, partially restored expression of PDE6B, REEP6, and RDH12 and finally mitigated retinal degeneration. Collectively, our study highlights critical roles of WTAP in photoreceptor function and survival, thus providing novel therapeutic strategies for IRDs. - Source: PubMed
Publication date: 2026/03/04
Sun KuanxiangZhang LinLiu WenjingChen CanHe JiajieCai JinruiJiang XiaoyanYang YemingYang ZhenglinZhu Xianjun - A human induced pluripotent stem cell (hiPSC) line BTHBIOi006-A was generated from peripheral blood mononuclear cells of a patient carrying RDH12 biallelic mutations via episomal reprogramming. The line exhibits a normal karyotype, expresses pluripotent markers, differentiates into three germ layers, and is mycoplasma-free, serving as a tool for retinal disease research. - Source: PubMed
Publication date: 2026/02/18
Zhang Zhi-HanZhang Xiao-HuiJin Zi-Bing