Ask about this productRelated genes to: RDH11 antibody
- Gene:
- RDH11 NIH gene
- Name:
- retinol dehydrogenase 11
- Previous symbol:
- -
- Synonyms:
- MDT1, SDR7C1, ARSDR1
- Chromosome:
- 14q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-11
- Date modifiied:
- 2018-02-09
Related products to: RDH11 antibody
Related articles to: RDH11 antibody
- Biallelic variants in RDH11, encoding retinol dehydrogenase 11, have been associated with a syndromic disorder, based on 4 individuals from 2 unrelated families. We aimed to profile the clinical variability, natural history and associated molecular spectrum of this condition. - Source: PubMed
Publication date: 2026/03/25
Radio Francesca ClementinaTasca GiorgioCoppens SandraChillemi GiovanniWhalen SandraMarey IsabelleLeoni ChiaraOnesimo RobertaDeconinck NicolasD'Amico AdeleRemiche GauthierNascimento AndresOrtez CarlosJou CristinaLecomte SophieFalsini BenedettoCiolfi AndreaFerilli MarcoCappelletti CamillaNiceta MarcelloGowda Vykuntaraju KSrinivasan Varunvenkat MVahidi Mehrjardi Mohammad YahyaDadbinpour AliMovahedinia MojtabaFiroozfar ZahraAlavi ShahryarAlibakhshi RezaGhazinader DonyaMojarrad MajidRajati MohsenKeren BorisBertini Enrico SilvioZampino GiuseppeNatera de Benito DanielMaroofian RezaTartaglia Marco - Lung cancer is one of the leading causes of cancer-related deaths, among which NSCLC accounts for approximately 80-85% of all lung cancer cases. Paclitaxel (TAX) is a commonly used chemotherapeutic drug, but it is easy to cause drug resistance. Fluvastatin has anti-cancer potential, but the mechanism of its reversal of drug resistance is unclear. - Source: PubMed
Publication date: 2026/02/16
Xu HongyuDu ZedongShui JiaLi XuetingTang JuanLi Guangquan - Retinol dehydrogenases (RDHs) catalyze multiple steps in the visual cycle to regenerate 11-cis-retinal, a critical component in rod phototransduction. The structural homology between RDHs enables functional redundancy; yet Mendelian disorders are linked to RDHs. Variants in RDH12 and RDH5 cause non-syndromic inherited retinal dystrophy (IRD), whilst variants in RDH11 cause syndromic IRD. RDH11 is a minor isoenzyme catalyzing two reactions: (i) reduction of all-trans-retinal in rod photoreceptors alongside RDH12 and RDH8, and (ii) oxidation of 11-cis-retinol in the retinal pigment epithelium (RPE) alongside RDH5 and RDH10. Prior cases with RDH11 demonstrated a generalized photoreceptor dystrophy, similar to RDH12-retinopathy. We describe a visually asymptomatic 7-year-old boy carrying a homozygous null variant in RDH11 [NM_016026.4:c.216C>A:p.(Cys72*)] with autism, dysmorphic features, oligodontia, microcephaly and a novel IRD. This retinopathy consisted of yellow deposits and hyperpigmentation within the RPE with absent autofluorescence and a normal electroretinogram implying sub-optimal oxidation of 11-cis-retinol. These features are reminiscent of RDH5-retinopathy but milder. We termed this phenotype Retinal pigment Epitheliopathy due to Sub-Optimal Recycling of Vitamin A (RESORVA). We propose that the divergence in retinal phenotypes among RDH11 cases is likely due to variant-specific protein effects on paralogous gene functioning, such as differences in activation of transcriptional adaptation. - Source: PubMed
Publication date: 2025/12/29
Stephenson Kirk A JShao ZhuoTumber AnupreetTavares ErikaAhmed KashifHigginbotham Edward JMarshall Christian RMaynes Jason TRajala AmmajiRajala Raju V SHéon EliseVincent Ajoy - Ellagic acid (EA), a bioactive polyphenol abundant in pomegranate and berries, exhibits potential in metabolic regulation. This study investigates EA's anti-obesity mechanisms, focusing on its effects on gut microbiota and transcriptional regulation in adipose tissue. After a 9-week high-fat diet feeding, mice were divided into groups and treated with low-dose EA (10 mg/kg/day), high-dose EA (30 mg/kg/day), or urolithin A (20 mg/kg/day) for 7 weeks, with healthy and obese controls included. In diet-induced obese mice, a 7-week EA intervention (10 mg/kg/day) significantly reduced adiposity (-46.96%, p < 0.01) and improved serum lipid profiles. Transcriptome analysis revealed PPARγ upregulation (380.34%, p < 0.001) and retinol metabolism activation (Rdh11, 1.51-fold) in white adipose tissue. Gut microbiota analysis showed that low-dose EA inhibited Mailhella massiliensis abundance (73.64%, p < 0.001). It also enhanced nocturnal energy expenditure (56.79%, p < 0.05) and improved antioxidant capacity. In contrast, high-dose EA and UroA neither activated these pathways nor suppressed harmful bacteria, and physical activity levels remained unchanged. Low-dose EA ameliorates obesity via PPARγ-mediated lipid metabolism, retinol metabolism activation, and gut microbiota modulation (M. massiliensis suppression). EA-rich foods may serve as functional dietary strategies for obesity management. - Source: PubMed
Publication date: 2025/09/06
Geng XinLi QingcuiZhou FanPang XiaozeSun JinQi Ce - With the global epidemic of obesity and diabetes, non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease, and NASH is increasingly becoming a major risk factor for hepatocellular carcinoma. Therefore, it is essential to explore novel biomarkers in NASH-related HCC. - Source: PubMed
Publication date: 2025/04/05
Liu QiqiYang YinuoWang YongshuaiWei ShuhangYang LiuLiu TiantianYu ZhenFeng YueminYao PingZhu Qiang