Ask about this productRelated genes to: RCAN2 antibody
- Gene:
- RCAN2 NIH gene
- Name:
- regulator of calcineurin 2
- Previous symbol:
- DSCR1L1
- Synonyms:
- ZAKI-4
- Chromosome:
- 6p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2014-11-19
Related products to: RCAN2 antibody
Related articles to: RCAN2 antibody
- This study aims to explore potential biological biomarkers for brucellosis by integrating transcriptomic profiling and bioinformatics-driven approaches. - Source: PubMed
Publication date: 2026/02/04
Wang RuiHe JuanLi XiaoShi YueDuan HuijuanDing Haitao - Air pollution is associated with Alzheimer's disease (AD), and the susceptibility of AD from air pollution may be affected by genetic characteristics, but the underlying mechanisms remain unknown. - Source: PubMed
Publication date: 2026/01/23
Ran ShanshanZhang JingyiCai MiaoChen LanQian ZhengminTian FeiWu GanBoyd Ri'ennaMcMillin Stephen EdwardZeng Huai-CaiYang YinLin Hualiang - To investigate the interaction between type 3 innate lymphoid cells (ILC3) and regulatory T cells (Treg) in patients with fibrostenotic Crohn's disease (CD) using single-cell sequencing analysis. The clinical data of patients diagnosed with fibrostenotic CD were retrospectively collected from the Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University (Wenzhou group) and the Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Ruijin group) between January 31, 2023, and June 30, 2024. Fresh intestinal fibrotic tissue samples and non-fibrotic intestinal tissue samples were obtained from each patient for single-cell RibonucleicAcid sequencing (scRNA-seq), differential gene enrichment analysis, etc. The Wenzhou group included 1 patient (male, 29 years old). The Ruijin group included 6 patients [4 males, 2 females, with a median age of 41 (27-52) years]. All cells from the intestinal tissues of both groups were categorized into the following 9 major types: T lymphocytes/innate lymphoid cells (ILC), B lymphocytes, plasma cells, macrophages, epithelial cells, fibroblasts, mast cells, neutrophils, and glial cells. Co-analysis of cell types in the intestinal tissues from both groups revealed that the proportion of ILC3 was lower in fibrotic tissue compared to non-fibrotic tissue (0.71% vs 3.26%, =0.042). Furthermore, in fibrotic tissues, the expression levels of genes related to antigen presentation, including chemokine motif ligand (CCL)3, CCL4, interferon-γ (IFN-γ), interleukin-2 receptor subunit alpha (IL2RA), regulator of calcineurin 2 (RCAN2), and tumor necrosis factor superfamily member 4 (TNFSF4) were higher in ILC3 compared to non-fibrotic tissues. In the Wenzhou group's intestinal tissues, interactions were observed between ILC3 and Treg, epithelial cells and neutrophils. In the Ruijin group's intestinal tissues, interactions were observed between ILC3 and Treg cells. ILC3 disrupts the intestinal immune microenvironment through interactions with Treg cells, thereby promoting the progression of fibrostenotic CD. - Source: PubMed
Li J CMao X LZhao RZhang YChen Y XZuo Z GShi L YChen X RHuang X LYan L LChen Q WLu M MZhong C YWu F - Circular RNAs (circRNAs) are looped RNA molecules with regulatory roles in myocardial infarction and post-infarction cascades. We aimed to (i) confirm the circularity of novel circRNAs (CDR1as, circ-RCAN2, circ-C12orf29) implicated in myocardial infarction, (ii) examine cell-specific regulation patterns under hypoxia, and (iii) assess their effects on cell viability and downstream miRNA targets. Experiments were conducted on porcine cardiac progenitor cells (pCPCs), bone marrow mesenchymal stem cells (pMSCs) and cardiac fibroblasts (pCFs). Circularity was assessed by RNase R treatment, subsequent qPCR, gel electrophoresis and Sanger sequencing. Hypoxia experiments with/without serum deprivation mimicked ischemia. Effects on viability with/without hypoxia (MTT assay) and downstream miRNA targets were assessed via short interfering RNA (siRNA)-mediated knockdown of circ-RCAN2 and circ-C12orf29. Following RNase R treatment, qPCR product electrophoresis demonstrated amplification of singular products for all circRNAs, with backsplice junction amplification confirmed via Sanger sequencing. Serum deprivation and hypoxia resulted in cell-specific circRNA expression patterns, with an upregulation of all candidates in pCPCs across all intervals of hypoxia, an upregulation of circ-RCAN2 and circ-C12orf29 in pMSCs with prolonged hypoxia, and no detectable dysregulation in pCFs. siRNA knockdown of circ-RCAN2 reduced pCF- and increased pMSC-viability. circ-C12orf29 knockdown increased pCPC- and reduced pMSC-viability. circ-C12orf29 knockdown also upregulated ssc-miR-21-5p and ssc-miR-181c in pCPCs, with no detectable targets for circ-RCAN2. In conclusion, CDR1as, circ-RCAN2 and circ-C12orf29 are circular and dysregulated in a time- and cell-type-specific manner following hypoxia. circ-RCAN2 and circ-C12orf29 exhibit cell-type specific effects on viability, with circ-C12orf29 also targeting downstream miRNAs. - Source: PubMed
Publication date: 2025/10/23
Hasimbegovic EnaLukovic DominikaKastner NinaHofer Benedikt SSpannbauer AndreasTraxler DeniseMester-Tonczar JuliaHamzaraj KevinHan EmilieRiesenhuber MartinMaleiner BabetteMüller-Zlabinger KatrinGyöngyösi Mariann - : Most studies investigating prognostic biomarkers in cervical cancer (CC) analyze patients irrespective of FIGO stage, potentially masking molecular features that underlie the aggressiveness of some FIGO II tumors. To address this, we investigated differential gene expression in a FIGO II CC cohort to identify a gene signature predictive of progression-free survival (PFS) within five years of treatment initiation. : Tumor samples from 15 CC patients were analyzed using RNA sequencing, bioinformatics, and machine learning to identify differentially expressed genes (DEGs) associated with prognosis. Findings were validated in an independent CC cohort ( = 174). : High expression of B3GALT1 (HR = 5.11), GTF3C2-AS1 (HR = 18.73), and ZKSCAN4 (HR = 5.18) was significantly associated with an increased risk of recurrence in our cohort. Elevated expression of these transcripts is also associated with shorter PFS in the external dataset. Notably, GTF3C2-AS1 expression alone was sufficient to classify all fifteen patients into their respective prognostic groups using a decision tree model, achieving 93.3% accuracy in leave-one-out cross-validation (LOOCV). Additional candidates, including RCAN2-DT, MYH9-DT, IGKC, IGHG1, and IGHG3, were associated with PFS in our cohort but could not be externally validated due to a lack of available data. : Transcriptomic profiling revealed potential biomarkers that refine prognostic stratification in cervical cancer beyond FIGO staging. Among them, GTF3C2-AS1 consistently emerged as a potential predictor of recurrence risk. Additional candidates, including B3GALT1, ZKSCAN4, and immunoglobulin transcripts, provided complementary insights but require further validation. These preliminary results highlight intra-stage heterogeneity in FIGO II CC and underscore the promise of molecular markers to improve risk assessment. - Source: PubMed
Publication date: 2025/10/16
Melo Carolina P SMelo Angelo BQueiroz Fábio RCosta Álvaro PAmaral Laurence RPereira Ramon AAmorim Izabela F GFerreira Jorge G GJeremias Wander JBertarini Pedro L LGomes Matheus SBraga Letícia CSalles Paulo G O