Ask about this productRelated genes to: RBMX2 antibody
- Gene:
- RBMX2 NIH gene
- Name:
- RNA binding motif protein X-linked 2
- Previous symbol:
- -
- Synonyms:
- CGI-79, Snu17
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-02
- Date modifiied:
- 2018-04-26
Related products to: RBMX2 antibody
Related articles to: RBMX2 antibody
- Tuberculosis (TB) is a complex disease caused by the interaction of pathogen, host, and environmental factors. In 2022, TB affected 10.6 million people and caused 1.3 million deaths globally. In high-burden zoonotic TB regions, accounts for ~10% of human TB cases. The immune evasion and latency of hinder understanding of host responses. Here, we identify RNA-binding motif protein X-linked 2 (RBMX2) as a novel host factor facilitating infection. RBMX2 expression is significantly upregulated in multiple cell types, including EBL, BoMac, bovine alveolar primary cells, and human A549 cells. Multi-omics analyses, cell adhesion assays, and ChIP-PCR demonstrate that RBMX2 suppresses cell adhesion and tight junctions while enhancing adhesion and invasion via p65 signaling. Integrated transcriptomic, proteomic, and metabolomic data reveal that RBMX2 regulates epithelial-mesenchymal transition (EMT), a process linked to cancer progression. TIMER2.0 analysis shows elevated RBMX2 expression in lung adenocarcinoma and lung squamous cell carcinoma tissues, validated by immunofluorescence. Using an -induced BoMac-EBL EMT model and H1299 cells, we show that RBMX2 promotes EMT through p65/MMP-9 pathway activation. Collectively, RBMX2 is a novel host factor that enhances infection and drives infection-induced EMT. These findings provide new insight into TB pathogenesis and highlight RBMX2 as a potential target for TB vaccine and therapeutic development. - Source: PubMed
Publication date: 2025/11/24
Wang ChaoPeng YongchongYang HongxinJiang YanzhuKhalid Abdul KarimZhang KailunXie ShengsongBermudez LuizYang YongZhang LeiChen HuanchunGuo AizhenChen Yingyu - X-chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals. Given that the Xchromosome harbours numerous genes implicated in cognitive function, variants in these genes can affect neurodevelopment and contribute to Intellectual Disability (ID). While research on ID has predominantly focused on males due to their hemizygous Xchromosome state, females, though often presenting with milder symptoms, may be affected by escape genes that evade XCI and influence the phenotype. This study investigated the role of escape genes in female ID. - Source: PubMed
Publication date: 2025/06/24
de Oliveira Lizandra AbreuPiergiorge Rafael MinaSantos-Rebouças Cíntia Barros - The variant bovis () is a highly pathogenic environmental microorganism that causes bovine tuberculosis (bTB), a significant zoonotic disease. Currently, "test and culling" is the primary measure for controlling bTB, but it has been proven to be inadequate in animals due to their high susceptibility to the pathogen. Selective breeding for increased host resistance to bTB to reduce its prevalence is feasible. In this study, we found a vital host-dependent factor, , that can potentially promote infection. By knocking out, we investigated its function during infection. Through transcriptome sequencing and alternative splicing transcriptome sequencing, we concluded that after infection, embryo bovine lung (EBL) cells were significantly enriched in RNA splicing associated with apoptosis compared with wild-type EBL cells. Through protein/molecular docking, molecular dynamics simulations, and real-time quantitative PCR, we demonstrated that promotes the apoptosis of epithelial cells by upregulating and binding to apoptotic peptidase activating factor 1 (APAF-1), resulting in the alternative splicing of APAF-1 as a retention intron. To our knowledge, this is the first report of affecting host epithelial cell apoptosis by hijacking to promote the intron splicing of downstream APAF-1. These findings may represent a significant contribution to the development of novel TB prevention and control strategies. - Source: PubMed
Publication date: 2024/09/06
Wang ChaoJiang YanzhuYang ZhimingXu HaojunKhalid Abdul KarimIftakhar TahiraPeng YongchongLu LuZhang LeiBermudez LuizGuo AizhenChen Yingyu - We have used long-read single molecule, real-time (SMRT) sequencing to fully characterize a ~12Mb genomic region on chromosome Xq24-q27, significantly linked to bipolar disorder (BD) in an extended family from a genetic sub-isolate. This family segregates BD in at least four generations with 24 affected individuals. - Source: PubMed
Publication date: 2021/12/16
Laine PiaRowell William JPaulin LarsKujawa SteveRaterman DeniseMayhew GeorgeWendt JenniferBurgess Daniel LPartonen TimoPaunio TiinaAuvinen PetriEkholm Jenny M - Tropical theileriosis is the disease caused by tick-transmitted apicomplexan parasite , which has ability to transform bovine leukocytes, including B cells, macrophage cells, and dendritic cells. The transformed cells are characterized as uncontrolled proliferation and shared some cancer-like phenotypes. The mechanism of the transformation by is still not understood well. In previous reports, the subtelomere-encoded variable secreted proteins (SVSP) of were considered to contribute to phenotypic changes of the host cell, but the role of SVSP of in host-pathogen relationship remains unknown. In the present study, a member of SVSP family, TA05575 of was selected as the target molecule to analyze its expression profiles in different life cycle stages of by qPCR and investigate its subcellular distribution of different passages of transformed cells using confocal experiments. From the results, the transcription level of TA05575 at schizont stage was significantly higher than the other two life stages of , and the protein of TA05575 was mainly distributed in nucleus of infected cells. In addition, the potential proteins of host cells interacting with TA05575 were screened by Yeast-two hybrid system. The results of Co-IP experiment confirmed that TA05575 interacted with RBMX2-like protein that participated in transcription regulation of cells. In addition, a novel BiFC assay and flow cytometry were carried out, and the results further revealed that TA05575-RBMX2-like pair was directly interacted in cell context. Moreover, this interacting pair was found to distribute in intracellular compartments of HEK293T cells by using confocal microscopy. The results of the present study suggest that TA05575 may contribute for cells transformation due its distribution. According to the function of RBMX2, the interaction of TA05575 and RMMX2-like will provide a new information to further understand the mechanisms of cells transformation by . - Source: PubMed
Publication date: 2021/02/26
Li ZhiLiu JunlongZhao ShuaiyangMa QuanyingLiu AihongLi YouquanGuan GuiquanLuo JianxunYin Hong