Ask about this productRelated genes to: RBM4B antibody
- Gene:
- RBM4B NIH gene
- Name:
- RNA binding motif protein 4B
- Previous symbol:
- RBM30
- Synonyms:
- MGC10871, ZCCHC15, RBM4L, ZCRB3B, ZCCHC21B
- Chromosome:
- 11q13
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-19
- Date modifiied:
- 2019-03-19
Related products to: RBM4B antibody
Related articles to: RBM4B antibody
- This study investigates the shared genetic architecture between anxiety disorders (ADs) and ten autoimmune diseases: rheumatoid arthritis (RA), Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO), mixed connective tissue disease (MCTD), graves' disease (GD), ankylosing spondylitis (AS), Sjögren's syndrome (SS), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). It aims to identify shared risk loci, key immune traits, and genetic mechanisms contributing to the pathophysiology of these conditions. - Source: PubMed
Publication date: 2025/07/26
Lin HaitaoXiao YaoLiu YingqiaoLin XiaoyangLiu Xiqiang - Pancreatic ductal adenocarcinoma (PADA) represents a devastating type of pancreatic cancer with high mortality. Defining a prognostic gene signature that can stratify patients with different risk will benefit cancer treatment strategies. - Source: PubMed
Publication date: 2023/01/09
Jin YuGong ShuangShang GuochenHu LilinLi Gangping - 5XFAD humanized mutant mice and Trem2 knockout (T2KO) mice are two mouse models relevant to the study of Alzheimer's disease (AD)-related pathology. - Source: PubMed
Weller Andrew EFerraro Thomas NDoyle Glenn AReiner Benjamin CCrist Richard CBerrettini Wade H - High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade familial pancreatic cancer (FPC)-related PanIN lesions may characterize the molecular events during the progression from familial PanIN to PDAC. We performed weighted gene coexpression network analysis (WGCNA) to identify clusters of coexpressed genes associated with FPC-related PanIN lesions in 13 samples with PanIN-2/3 from FPC predisposed individuals, 6 samples with PDAC from sporadic pancreatic cancer (SPC) patients, and 4 samples of normal donor pancreatic tissue. WGCNA identified seven differentially expressed gene (DEG) modules and two commonly expressed gene (CEG) modules with significant enrichment for Gene Ontology (GO) terms in FPC and SPC, including three upregulated ( < 5e-05) and four downregulated ( < 6e-04) gene modules in FPC compared to SPC. Among the DEG modules, the upregulated modules include 14 significant genes ( < 1e-06): , , , , , , , , , , , , , and . The downregulated modules include 170 genes ( < 1e-06), among them 13 highly significant genes ( < 1e-10): , , , , , , , , , , , , and . The DEG modules are enriched for GO terms related to mitochondrial structure and adenosine triphosphate metabolic processes, extracellular structure and binding properties, humoral and complement mediated immune response, ligand-gated ion channel activity, and transmembrane receptor activity. Among the CEG modules, , , and were found as highly connective hub genes associated with both FPC and SPC. FPC-related PanIN lesions exhibit a common molecular basis with SPC as shown by gene network activities and commonly expressed high-connectivity hub genes. The differential molecular pathology of FPC and SPC involves multiple coexpressed gene clusters enriched for GO terms including extracellular activities and mitochondrion function. - Source: PubMed
Publication date: 2020/08/05
Tan MingSchaffalitzky de Muckadell Ove BJøergensen Maiken Thyregod - The RNA binding motif protein 4 genes RBM4a and RBM4b are located on human chromosome 11q13.2 and encode highly similar proteins of 363 and 359 amino acids, respectively. They contain two RNA recognition motifs (RRMs) and a retroviral-type Zn-finger. RBM4a binds RNA, is involved in alternative splicing and is also a part of the microRNA-processing RISC complex. In particular, RBM4a is involved in exon 10 inclusion of the tau protein. The function of RBM4b is unknown. With new monoclonal antibodies we show that RBM4a is detectable in virtually all tissues and cell lines tested while RBM4b was only found in kidney and liver. Both RBM4a and RBM4b are nuclear phosphoproteins with half-lives of 2.5h and 4.5h, respectively. To our knowledge, this is the first description of RBM4b protein in human tissue. In human brain, expression of RBM4a was strongly up-regulated in cerebellum as compared to forebrain. - Source: PubMed
Publication date: 2008/08/08
Pfuhl ThorstenMamiani AlfredoDürr MatthiasWelter SusanneStieber JohannaAnkara JasminLiss MichaelDobner ThomasSchmitt AndreaFalkai PeterKremmer ElisabethJung VolkerBarth StephanieGrässer Friedrich A