Ask about this productRelated genes to: RBM19 antibody
- Gene:
- RBM19 NIH gene
- Name:
- RNA binding motif protein 19
- Previous symbol:
- -
- Synonyms:
- DKFZp586F1023, KIAA0682, Mrd1
- Chromosome:
- 12q24.13-q24.21
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-02
- Date modifiied:
- 2018-02-13
Related products to: RBM19 antibody
Related articles to: RBM19 antibody
- Hepatocellular carcinoma (HCC), the most common type of liver cancer, exhibits the highest incidence in Asia and Africa. However, the mechanisms underlying the malignant transformation of normal cells to HCC cells remain poorly understood. MYC-associated protein X (MAX) functions as an oncogenic transcription factor (TF) in HCC by binding to E-box elements in promoters or enhancers of target gene. Using our previously developed Updated Integrative Functional Genomics Approach (TUIFGA), we identified 248 single nucleotide polymorphisms (SNPs) within MAX-binding sites in HCC cells. Among these SNPs, rs2290798 in the RBM19 promoter was significantly associated with HBV-related HCC risk. Functional assays indicated that the rs2290798 genetic variant could disrupt TF MAX binding to the RBM19 promoter and downregulate RBM19 expression. RBM19 acts as an oncogenic RNA-binding protein (RBP) through promoting proliferation, migration, and invasion of HCC cells. Indeed, RBM19 functions as a RBP via stabilizing several oncogenic transcripts (C1QTNF6, GLS1, MALAT1 or RBM19) and elevating their expression levels in HCC. These findings highlight the curial role of RBM19 in HCC progression and its potential as a therapeutic target in cancers. - Source: PubMed
Publication date: 2025/08/05
Zheng YanxiuYin XiaoleiHan LinyuLiu ShuqingZhang NashaYang YantingYang Ming - RBM family proteins plays the critical role in the progression of numerous tumors. However, whether RBM family proteins involved in prostate cancer (PCa) progression is remain elucidated. In our study, an RNAi screen containing shRNA library targeting 54 members of the RBM family was applied to identify the critical RBM proteins involved in prostate cancer progression under docetaxel treatment, and RBM19 was selected. RBM19 was up-regulated in PCa specimens and correlated with the prognosis and Gleason score of PCa patients. Functionally assays revealed that RBM19 promoted PCa progression under docetaxel treatment both in vivo and in vitro. Mechanistically, RBM19 could bind to LncRNA SNHG21, thereby increased SNHG21 expression through enhancing its stability. Furthermore, SNHG21 bind to PIM1 proteins and prevented it from ubiquitin-protease dependent degradation and ultimately enhancing mitochondrial homeostasis. Overall, our study indicates the RBM19/SNHG21/PIM1 axis may be the encouraging target for docetaxel-tolerance PCa treatment. - Source: PubMed
Publication date: 2024/12/27
Zhuang WeiXu SiweiHe QingliuSu QingfuChen HeyiChen JiabiHuang CongmingYou Zhijiao - The meat production of broilers is crucial to economic benefits of broiler industries, while the slaughter performance of broilers is directly determined by skeletal muscle development. Hence, the broiler breeding for growth traits shows a great importance. As a kind of small noncoding RNA, microRNA (miRNA) can regulate the expression of multiple genes and perform a wide range of regulation in organisms. Currently, more and more studies have confirmed that miRNAs are closely associated with skeletal muscle development of chickens. Based on our previous miR-seq analysis (accession number: PRJNA668199), miR-460b-5p was screened as one of the key miRNAs probably involved in the growth regulation of chickens. However, the regulatory effect of miR-460b-5p on the development of chicken skeletal muscles is still unclear. Therefore, miR-460b-5p was further used for functional validation at the cellular level in this study. The expression pattern of miR-460b-5p was investigated in proliferation and differentiation stages of chicken primary myoblasts. It was showed that the expression level of miR-460b-5p gradually decreased from the proliferation stage (GM 50%) to the lowest at 24 h of differentiation. As differentiation proceeded, miR-460b-5p expression increased significantly, reaching the highest and stabilizing at 72 h and 96 h of differentiation. Through mRNA quantitative analysis of proliferation marker genes, CCK-8 and Edu assays, miR-460b-5p was found to significantly facilitate the transition of myoblasts from G1 to S phase and promote chicken myoblast proliferation. mRNA and protein quantitative analysis of differentiation marker genes, as well as the indirect immunofluorescence results of myotubes, revealed that miR-460b-5p significantly stimulated myotube development and promote chicken myoblast differentiation. In addition, the target relationship was validated for miR-460b-5p according to the dual-luciferase reporter assay and mRNA quantitative analysis, which indicates that miR-460b-5p was able to regulate RBM19 expression by specifically binding to the 3' UTR of RBM19. In summary, miR-460b-5p has positive regulatory effects on the proliferation and differentiation of chicken myoblasts, and RBM19 is a target gene of miR-460b-5p. - Source: PubMed
Publication date: 2023/10/24
Zhou Kai-ZhiWu Peng-FeiLing Xuan-ZeZhang JinWang Qi-FanZhang Xin-ChaoXue QianZhang TaoHan WeiZhang Gen-Xi - Although some RBM proteins family members play important roles in hepatocellular carcinoma (HCC) development, their value of prognosis and tumor treatment is not clear. To reveal the expression patterns and clinical significance of RBM family members in HCC, we constructed a RBM family-based prognosis signature. - Source: PubMed
Publication date: 2023/07/06
Wu ZhengqiangGuo LiWan LijunXu KedongLuo LinfeiWen Zhili - During early HIV-1 infection, immunodominant T cell responses to highly variable epitopes lead to the establishment of immune escape virus variants. Here we assessed a type 1-polarized monocyte-derived dendritic cell (MDC1)-based approach to selectively elicit cytotoxic T lymphocyte (CTL) responses against highly conserved and topologically important HIV-1 epitopes in HIV-1-infected individuals from the Thailand RV254/SEARCH 010 cohort who initiated antiretroviral therapy (ART) during early infection (Fiebig stages I-IV). - Source: PubMed
Publication date: 2021/01/12
Garcia-Bates Tatiana MPalma Mariana LAnderko Renee RHsu Denise CAnanworanich JintanatKorber Bette TGaiha Gaurav DPhanuphak NittayaThomas RasmiTovanabutra SodsaiWalker Bruce DMellors John WPiazza Paolo AKroon EugeneRiddler Sharon AMichael Nelson LRinaldo Charles RMailliard Robbie B