Ask about this productRelated genes to: RASGEF1A antibody
- Gene:
- RASGEF1A NIH gene
- Name:
- RasGEF domain family member 1A
- Previous symbol:
- -
- Synonyms:
- CG4853, FLJ37817
- Chromosome:
- 10q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-04
- Date modifiied:
- 2015-11-09
Related products to: RASGEF1A antibody
Related articles to: RASGEF1A antibody
- Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investigation into the mechanisms driving resistance to Osimertinib is necessary to address the restricted treatment options and survival advantages that are compromised by resistance in patients with EGFR-mutated lung adenocarcinoma (LUAD). - Source: PubMed
Publication date: 2025/01/07
Sun DantongHou HeleiFeng FeiyueWu WeizhengTan JingyuXie TongjiLiu JiayuWang JinsongQian HailiLi JunlingXing Puyuan - Breast cancer (BC) comprises multiple subtypes with distinct molecular features, which differ in their interplay with host immunity, prognosis, and treatment. Non-invasive blood analyses can provide valuable insights into systemic immunity during cancer. The aim of this study was to analyze the expression of transcriptional isoforms in peripheral blood mononuclear cells (PBMCs) from BC patients and healthy women to identify potential BC immune biomarkers. RNA sequencing and isoform-level bioinformatics were performed on PBMCs from 12 triple-negative and 13 luminal A patients. Isoform expression validation by qRT-PCR and clinicopathological correlations were performed in a larger cohort (156 BC patients and 32 healthy women). Transcriptional analyses showed a significant ( < 0.001) decrease in the isoform in PBMCs of BC compared to healthy subjects, indicating disease-related expression changes. The decrease was associated with higher ctDNA and Ki-67 values. The levels of the transcriptional isoform may have the potential to distinguish between BC and healthy subjects. The downregulation of in breast cancer is associated with higher proliferation and ctDNA shedding. Specialized bioinformatics analyses such as isoform analyses hold significant promise in the detection of biomarkers, since standard RNA sequencing analyses may overlook specific transcriptional changes that may be disease-associated and biologically important. - Source: PubMed
Publication date: 2024/09/16
Čelešnik HelenaGorenjak MarioKrušič MartinaCrnobrnja BojanaSobočan MonikaTakač IztokArko DarjaPotočnik Uroš - Hip or knee osteoarthritis (OA) is one of the main causes of disability worldwide and occurs mostly in the older adults. Total hip or knee arthroplasty is the most effective method to treat OA. However, severe postsurgical pain leading to a poor prognosis. So, investigating the population genetics and genes related to severe chronic pain in older adult patients after lower extremity arthroplasty is helpful to improve the quality of treatment. - Source: PubMed
Publication date: 2023/03/09
Xu RuiJin YinanTang SuhongWang WenwenSun Yu-ELiu YueZhang WeiHou BailingHuang YulinMa Zhengliang - Acute myeloid leukemia (AML) is a significantly heterogeneous malignancy of the blood. Cytogenetic abnormalities are crucial for the prognosis of AML. However, since more than half of patients with AML are cytogenetically normal AML (CN-AML), predictive prognostic indicators need to be further refined. In recent years, gene abnormalities are considered to be strong prognostic factors of CN-AML, already having clinical significance for treatment. In addition, the relationship of methylation in some genes and AML prognosis predicting has been discovered. RASGEF1A is a guanine nucleotide exchange factors of Ras and widely expressed in brain tissue, bone marrow and 17 other tissues. RASGEF1A has been reported to be associated with a variety of malignant tumors, examples include Hirschsprung disease, renal cell carcinoma, breast cancer, diffuse large B cell lymphoma, intrahepatic cholangiocarcinoma and so on [1, 2]. However, the relationship between the RASGEF1A gene and CN-AML has not been reported. - Source: PubMed
He XueZhang WeilongFu WeiLiu XiaoniYang PingWang JingZhu MingxiaLi ShaoxiangZhang WeiZhang XiuruDong GehongYan ChangjianZhao YaliZeng ZhipingJing Hongmei - It is widely recognized that noncoding genetic variants play important roles in many human diseases, but there are multiple challenges that hinder the identification of functional disease-associated noncoding variants. The number of noncoding variants can be many times that of coding variants; many of them are not functional but in linkage disequilibrium with the functional ones; different variants can have epistatic effects; different variants can affect the same genes or pathways in different individuals; and some variants are related to each other not by affecting the same gene but by affecting the binding of the same upstream regulator. To overcome these difficulties, we propose a novel analysis framework that considers convergent impacts of different genetic variants on protein binding, which provides multiscale information about disease-associated perturbations of regulatory elements, genes, and pathways. Applying it to our whole-genome sequencing data of 918 short-segment Hirschsprung disease patients and matched controls, we identify various novel genes not detected by standard single-variant and region-based tests, functionally centering on neural crest migration and development. Our framework also identifies upstream regulators whose binding is influenced by the noncoding variants. Using human neural crest cells, we confirm cell stage-specific regulatory roles of three top novel regulatory elements on our list, respectively in the , , and loci. In the regulatory element, we further show that a noncoding variant found only in the patients affects the binding of the gliogenesis regulator NFIA, with a corresponding up-regulation of multiple genes in the same topologically associating domain. - Source: PubMed
Publication date: 2020/09/18
Fu Alexander XiLui Kathy Nga-ChuTang Clara Sze-ManNg Ray KitLai Frank Pui-LingLau Sin-TingLi ZhixinGarcia-Barcelo Maria-MercèSham Pak-ChungTam Paul Kwong-HangNgan Elly Sau-WaiYip Kevin Y