Ask about this productRelated genes to: RASGEF1A antibody
- Gene:
- RASGEF1A NIH gene
- Name:
- RasGEF domain family member 1A
- Previous symbol:
- -
- Synonyms:
- CG4853, FLJ37817
- Chromosome:
- 10q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-04
- Date modifiied:
- 2015-11-09
Related products to: RASGEF1A antibody
Related articles to: RASGEF1A antibody
- The oncogenes MYC and TAF2 (TATA-box binding protein associated factor 2) are frequently overexpressed and co-amplified in many cancers, including Hepatocellular Carcinoma (HCC). We recently demonstrated that overexpression of TAF2 in mouse liver markedly augmented MYC overexpression-induced HCC. MYC is a transcription factor. TAF2 is a component of transcription factor IID (TFIID) and functions as a transcription co-factor. We hypothesized that TAF2 modulates gene regulation by MYC, contributing to augmentation of MYC's oncogenic activity. To test this hypothesis, we generated stable HepG2 cell lines overexpressing TAF2, MYC, or both. Combined overexpression of TAF2 and MYC significantly augmented in vitro proliferation, migration and invasion, compared to the overexpression of each gene alone. We performed RNA-sequencing and CUT&RUN (cleavage under targets & release using nuclease) to identify MYC-regulated genes that are induced only by TAF2 overexpression. RASGEF1A (RasGEF domain family member 1A), a guanine exchange factor activating Ras, was significantly induced by TAF2 and MYC overexpression. Consequently, the MEK/ERK pathway was robustly activated in cells co-overexpressing TAF2 and MYC, rendering them uniquely sensitive to MEK inhibitor Trametinib. These findings suggest that HCC patients with TAF2 and MYC overexpression might benefit from targeted treatment with MEK inhibitors. - Source: PubMed
Publication date: 2026/09/18
Raha SuchismitaZhang QiongFarrar DevonTseng CharlesMendoza Rachel GYounis Rabha MRodriguez Kayla AIyer SamyuktaSubler Mark AWindle Jolene JLai ZhaoDozmorov MikhailPeng Jamy CSarkar Devanand - 1. Fatty acid (FA) composition determines the nutritional value of duck meat. Systematic characterisation of FA profiles in indigenous breeds, such as the certified Kaijiang Sheldrake, is essential for genetic improvement of meat quality.2. This study used gas chromatography-mass spectrometry (GC-MS) to comprehensively analyse the fatty acid composition in the breast muscle of 60 Kaijiang Sheldrake ducks and explored their potential genetic basis using genome-wide association analysis (GWAS).3. The GC-MS detected 51 FA, with saturated FA (SFA) accounting for the largest proportion (49.45%). Palmitic acid (C16:0, 27.96%), stearic acid (C18:0, 19.95%) and linoleic acid (C18:2n-6, 13.74%) were the most abundant. ω-3 and ω-6 polyunsaturated FA (PUFA) showed strong intra-series correlations. Several individual FA showed significant associations with phenotypic traits, including positive correlations with breast muscle weight and percentage ( < 0.05), whereas short-chain SFAs (C6:0, C13:0) and specific PUFA (C20:3n-3, C20:5n-3) were negatively associated with post-mortem pH (0 h). In contrast, no significant associations were detected between aggregated ω-3 and ω-6 indices and most slaughter or meat quality traits. GWAS further suggested potential associations for both saturated and unsaturated FA, identifying candidate genes, such as , , , , , and located near associated loci, with enrichment in metabolic pathways including carbohydrate metabolism and glycolysis.4. Overall, this study systematically evaluated slaughter performance, meat quality traits and the fatty acid composition of breast muscle in Kaijiang Sheldrake, providing comprehensive data to support the utilisation and precision breeding of local duck genetic resources. - Source: PubMed
Publication date: 2026/08/24
Yang ZRen JWang LLi LBai LPeng DZhou FZeng XLi YLiao YHu BLiu H - Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investigation into the mechanisms driving resistance to Osimertinib is necessary to address the restricted treatment options and survival advantages that are compromised by resistance in patients with EGFR-mutated lung adenocarcinoma (LUAD). - Source: PubMed
Publication date: 2025/01/07
Sun DantongHou HeleiFeng FeiyueWu WeizhengTan JingyuXie TongjiLiu JiayuWang JinsongQian HailiLi JunlingXing Puyuan - Breast cancer (BC) comprises multiple subtypes with distinct molecular features, which differ in their interplay with host immunity, prognosis, and treatment. Non-invasive blood analyses can provide valuable insights into systemic immunity during cancer. The aim of this study was to analyze the expression of transcriptional isoforms in peripheral blood mononuclear cells (PBMCs) from BC patients and healthy women to identify potential BC immune biomarkers. RNA sequencing and isoform-level bioinformatics were performed on PBMCs from 12 triple-negative and 13 luminal A patients. Isoform expression validation by qRT-PCR and clinicopathological correlations were performed in a larger cohort (156 BC patients and 32 healthy women). Transcriptional analyses showed a significant ( < 0.001) decrease in the isoform in PBMCs of BC compared to healthy subjects, indicating disease-related expression changes. The decrease was associated with higher ctDNA and Ki-67 values. The levels of the transcriptional isoform may have the potential to distinguish between BC and healthy subjects. The downregulation of in breast cancer is associated with higher proliferation and ctDNA shedding. Specialized bioinformatics analyses such as isoform analyses hold significant promise in the detection of biomarkers, since standard RNA sequencing analyses may overlook specific transcriptional changes that may be disease-associated and biologically important. - Source: PubMed
Publication date: 2024/09/16
Čelešnik HelenaGorenjak MarioKrušič MartinaCrnobrnja BojanaSobočan MonikaTakač IztokArko DarjaPotočnik Uroš - Hip or knee osteoarthritis (OA) is one of the main causes of disability worldwide and occurs mostly in the older adults. Total hip or knee arthroplasty is the most effective method to treat OA. However, severe postsurgical pain leading to a poor prognosis. So, investigating the population genetics and genes related to severe chronic pain in older adult patients after lower extremity arthroplasty is helpful to improve the quality of treatment. - Source: PubMed
Publication date: 2023/03/09
Xu RuiJin YinanTang SuhongWang WenwenSun Yu-ELiu YueZhang WeiHou BailingHuang YulinMa Zhengliang