Ask about this productRelated genes to: RAP2B antibody
- Gene:
- RAP2B NIH gene
- Name:
- RAP2B, member of RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-06
- Date modifiied:
- 2014-05-09
Related products to: RAP2B antibody
Related articles to: RAP2B antibody
- Targeted therapy resistance represents a significant clinical challenge in cancer treatment. Rap2B, a member of the Ras superfamily of small GTPases, is frequently overexpressed in various cancers and has been implicated in promoting tumor progression and therapy resistance. However, the role and underlying mechanisms of Rap2B in cetuximab resistance in colorectal cancer (CRC) remain to be elucidated. This study aims to investigate Rap2B expression patterns in CRC models and explore the mechanisms by which Rap2B mediates cetuximab resistance. - Source: PubMed
Publication date: 2025/10/15
Zhang ShanshanWei YingLiu TingtingSun ChenhaoGe XiuzhenNi YangTang XiaonanRoy MridulChang TingminKang Xiaohong - Cellular signaling by membrane G protein-coupled receptors (GPCRs) is governed by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome, as it evolves over time and space in response to an agonist, provide a unique perspective on pleiotropic signaling decoding and functional selectivity at the cellular level. In this study, we utilized proximity-based APEX2 proteomics to investigate the interaction network of the luteinizing hormone receptor (LHR) on a minute-to-minute timescale. We developed an analytical approach that integrates quantitative multiplexed proteomics with temporal reference profiles, creating a platform to identify the proteomic environment of APEX2-tagged LHR at the nanometer scale. LHR activity is finely regulated spatially, leading to the identification of putative interactors, including the Ras-related GTPase RAP2B, which modulate both receptor signaling and post-endocytic trafficking. This work provides a valuable resource for spatiotemporal nanodomain mapping of LHR interactors across subcellular compartments. - Source: PubMed
Shchepinova Maria MRichardson RachelHoughton Jack WWalker Abigail RSafar Mohammed AConole DanielHanyaloglu Aylin CTate Edward W - In this issue of Cell Chemical Biology, Shchepinova et al. map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics. - Source: PubMed
Shui Wenqing - Ras family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC). While Rap2B, a member of the Ras superfamily, has been linked to cancer malignancy in vitro, its exact role in tumorigenesis remains unclear. In this study, we demonstrated that intestine-specific knockout of Rap2B suppresses the initiation and progression of CRC. Mechanistically, Rap2B interacts with plectin and enhances its expression, which in turn inhibits plectin-mediated F-actin assembly. Deletion of Rap2B resulted in a remodeling of the intestinal cytoskeleton, leading to reduced tumorigenesis and diminished metastatic potential. Clinically, there is a positive correlation between the expression levels of Rap2B and plectin in human CRC tissues, and higher levels of Rap2B and plectin predicting poorer clinical outcome in CRC patients. These findings underscore a critical role of Rap2B in CRC progression and highlight its potential as a therapeutic target. - Source: PubMed
Publication date: 2025/04/13
Di JiehuiZhao ZhongjunXia MingyiGao KeyuChai KeliZhu BaoSun WanpingZhang YanpingZheng JunnianLiu Yong - Altered glucose metabolism is a critical characteristic from the beginning stage of esophageal squamous cell carcinoma (ESCC), and the phenomenon is presented as a pink-color sign under endoscopy after iodine staining. Therefore, calculating the metabolic score based on the glucose metabolic gene sets may bring some novel insights, enabling the prediction of prognosis and the identification of treatment choices for ESCC. - Source: PubMed
Zhang JiaqiSong ShunzheLi YuqingGong Aixia