Ask about this productRelated genes to: RAP2B antibody
- Gene:
- RAP2B NIH gene
- Name:
- RAP2B, member of RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-06
- Date modifiied:
- 2014-05-09
Related products to: RAP2B antibody
Related articles to: RAP2B antibody
- - Source: PubMed
Publication date: 2026/05/11
Shi GuohongZhang Zhen - Red swamp crayfish (Procambarus clarkii) is an economically important freshwater species in the world. The abdominal meat weight (AMW) and meat yield (MY) are the principal economic traits of the species. To identify SNPs and candidate genes associated with AMW and MY of the species, a genome-wide association study (GWAS) was conducted to genotype 410 individuals using a 50 K liquid-phase breeding SNP array. A total of 46,367 high-quality SNPs was identified. The Mixed Linear Model (MLM), Fixed and random model Circulating Probability Unification (FarmCPU), and Bayesian-information and Linkage-disequilibrium Iteratively Nested Keyway (BLINK) models were identified to be suitable for GWAS analysis of AMW and MY of the species. Eleven significant SNPs were identified to be associated with AMW and ten SNPs with MY trait, respectively. Seven candidate genes (FOXO, UBE4A, RAP2B, CCNO, CDK7, Mlp84B, and HK1) were linked to AMW trait, while three candidate genes (NDFIP1, PRKG1, and ADCY5) were associated with MY trait based on KEGG and GO enrichment analyses. These candidate genes are primarily involved in biological processes including cell cycle arrest, apoptosis, oxidative stress response, and metabolic homeostasis. The results would benefit to understanding the genetic basis of abdominal meat weight and meat yield traits and providing potential molecular markers for genetic improvement of crayfish. - Source: PubMed
Publication date: 2026/03/17
Li YongchuangWang QiujinSheng NaChen ZheyanWang YongqingJia LiangBai ZhiyiLi XileiLi JialeFeng Jianbin - BACKGROUND: Targeted therapy resistance represents a significant clinical challenge in cancer treatment. Rap2B, a member of the Ras superfamily of small GTPases, is frequently overexpressed in various cancers and has been implicated in promoting tumor progression and therapy resistance. However, the role and underlying mechanisms of Rap2B in cetuximab resistance in colorectal cancer (CRC) remain to be elucidated. This study aims to investigate Rap2B expression patterns in CRC models and explore the mechanisms by which Rap2B mediates cetuximab resistance. RESULTS: The expression level of Rap2B in CRC cell lines exhibits a significant negative correlation with sensitivity to cetuximab. In vivo experiments demonstrated that Rap2B downregulation significantly reduced tumor growth and enhanced cetuximab efficacy. Knockdown of Rap2B increases cetuximab sensitivity by inhibiting the PI3K/AKT signaling pathway, resulting in reduced cell proliferation and enhanced apoptosis. Conversely, overexpression of Rap2B induces cetuximab resistance by activating the PI3K/AKT pathway. CONCLUSION: This study highlights a close association between Rap2B overexpression and cetuximab resistance in CRC. The enhanced expression of Rap2B plays a pivotal role in conferring resistance, by activating the PI3K/AKT signaling pathway. Targeting Rap2B or its downstream pathways has the potential to provide novel therapeutic strategies for overcoming cetuximab resistance in colorectal cancer. - Source: PubMed
Publication date: 2025/10/15
Zhang ShanshanWei YingLiu TingtingSun ChenhaoGe XiuzhenNi YangTang XiaonanRoy MridulChang TingminKang Xiaohong - Cellular signaling by membrane G protein-coupled receptors (GPCRs) is governed by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome, as it evolves over time and space in response to an agonist, provide a unique perspective on pleiotropic signaling decoding and functional selectivity at the cellular level. In this study, we utilized proximity-based APEX2 proteomics to investigate the interaction network of the luteinizing hormone receptor (LHR) on a minute-to-minute timescale. We developed an analytical approach that integrates quantitative multiplexed proteomics with temporal reference profiles, creating a platform to identify the proteomic environment of APEX2-tagged LHR at the nanometer scale. LHR activity is finely regulated spatially, leading to the identification of putative interactors, including the Ras-related GTPase RAP2B, which modulate both receptor signaling and post-endocytic trafficking. This work provides a valuable resource for spatiotemporal nanodomain mapping of LHR interactors across subcellular compartments. - Source: PubMed
Shchepinova Maria MRichardson RachelHoughton Jack WWalker Abigail RSafar Mohammed AConole DanielHanyaloglu Aylin CTate Edward W - In this issue of Cell Chemical Biology, Shchepinova et al. map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics. - Source: PubMed
Shui Wenqing