Ask about this productRelated genes to: RAB31 antibody
- Gene:
- RAB31 NIH gene
- Name:
- RAB31, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- Rab22B
- Chromosome:
- 18p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2015-09-02
Related products to: RAB31 antibody
Related articles to: RAB31 antibody
- The interaction between tumour-associated neutrophils (TANs) and angiogenesis plays a crucial role in tumour progression. However, the specific regulatory mechanisms by which different TANs populations influence angiogenesis in colorectal cancer (CRC) remain poorly understood. - Source: PubMed
Publication date: 2026/02/26
Zong ZhenNing Zhi-KunHu CeguiJiang ShihaoYi HaoTang YingLuo QiulingYuan ChenweiZhu XiaopingZhu Xingen - Connexin43 (Cx43) is recognized as a transmembrane protein; its precise expression profile and molecular mechanisms in triple-negative breast cancer (TNBC) remain unclear. We systematically analyzed Cx43 expression in over 60 breast cancer cell lines from the CCLE and HPA databases. Immunohistochemical evaluation compared Cx43 expression between TNBC tissues and adjacent normal tissues. Cx43 expression was assessed in normal breast epithelial cells (MCF-10A) and two TNBC cell lines (MDA-MB-231 and BT-549) using qRT-PCR and Western blot. Functional assays (CCK8, wound healing, transwell) evaluated TNBC progression following Cx43 interference or overexpression. Rab31, a Cx43-interacting protein, was identified via bioinformatics, immunofluorescence, and Co-IP. Autophagy-related proteins (ULK1, ATG5, LC3, and p62) were analyzed after Cx43 or Rab31 modulation. Finally, a nude mouse model validated Cx43's in vivo effects on tumor growth and associated molecular changes. Cx43 was upregulated in TNBC tissues and cell lines. Overexpression enhanced proliferation, migration, and invasion, while knockdown suppressed these effects. Cx43 co-expressed with Rab31, regulating its protein levels and autophagy. Rab31 interference reversed Cx43-mediated autophagy and oncogenic behaviors. In vivo, Cx43 promoted tumor growth and modulated Rab31/autophagy pathways. The Cx43/Rab31 axis drives autophagy to facilitate TNBC progression, highlighting Cx43 as a potential therapeutic target. Our findings provide mechanistic insights for improving TNBC treatment. - Source: PubMed
Publication date: 2025/12/08
Yang JiaoWu DieYang TingLin Zi-JingJiang Pei-YaoWang Ting-RuiLu Zheng-JiaWang LuMing Jia - The objective of this research was to conduct a genome-wide association study to identify candidate genes associated with linear body measurements in South African Sussex cattle at weaning and yearling age. Overall, 96 South African Sussex animals (45 females and 51 males) were used for a GWAS with the Bovine 50K SNP BeadChip (Illumina, USA). The results indicated that three candidate genes, RAB31, BIRC5 and TEX22 were discovered as the prospective genetic markers for linear body measurements of the SA Sussex cattle at weaning age. Two candidate genes (CFAP100 and LOC617705) were discovered as prospective genetic markers for linear body measurements of the SA Sussex cattle at yearling age. The two candidate genes discovered for yearling age were positioned in the following areas: CFAP100 (3'UTR) and LOC617705 (exon 4), respectively. A noteworthy association (p < 0.05) was observed between RAB31, BIRC5, TEX22, CFAP100 and LOC617705 genes for linear body measurements of the SA Sussex cattle. However, three SNPs identified at weaning age: BovineHD1100019614, BovineHD1900015483 and ARS-BFGL-NGS-4967 were not located in any gene region. The findings of the current study might be used by cattle farmers to improve the linear body measurement traits of SA Sussex cattle. - Source: PubMed
Bila LubabaloMalatji Dikeledi PetuniaPutra Widya Pintaka BayuSanarana Yandisiwe PatienceTyasi Thobela Louis - To identify potential pivotal genes associated with Crohn's disease (CD) that may serve as potential diagnostic biomarkers. - Source: PubMed
Qiang RuanWei Lu YaSheng Gu Guo - Semen quality significantly affects the reproductive performance of ganders. As seasonal breeders, ganders typically experience a decline in semen quality over the breeding season; however, the mechanisms regulating semen quality stability during this period remain poorly understood. Maintaining high semen quality throughout the entire breeding season is crucial for improving production efficiency. In this study, we systematically investigated the semen quality parameters of Tianfu Meat Goose II ganders at three distinct stages of the female geese's annual laying cycle: early (36-week-old), peak (47-week-old), and late (66-week-old) laying stages. The results showed that the ganders in stable (S) semen quality group exhibited superior semen quality parameters compared to those in unstable (U) semen quality group. Notably, the gander semen quality factor (SQF) and sperm density were significantly higher in the S group than in the U group (P < 0.05). Histomorphological analysis revealed that the testicular weight and size of ganders from the S group were significantly greater than those from the U group (P < 0.05), and so were the numbers of testicular spermatids and spermatozoa (P < 0.05). Through a combination of transcriptomic and selective sweep analysis, protein-protein interaction network construction, and RT-qPCR validation, four hub genes (EP300, RAB31, PRKG1, and PIK3R1) and their significantly enriched KEGG pathways including adherens junction, gap junction, endocytosis, TGF-beta signaling, and Toll-like receptor signaling were identified to have important roles in regulating gander semen quality stability. Specifically, much higher levels of testicular EP300, RAB31, and PRKG1 expression might be associated with impaired semen quality in ganders from the U group, whereas the upregulated expression of PIK3R1 in testes of ganders from the S group appeared to play protective roles in maintaining the gander semen quality stability. These findings would provide novel insights into the molecular mechanisms underlying semen quality stability in ganders during the breeding season and offer valuable references for genetic selection and reproductive management in waterfowl breeding programs. - Source: PubMed
Publication date: 2025/10/24
Hu ShenqiangChen JiasenHe XiaoyongLi GuibiWang ZhujunZhang YujieSong YangLi XiaopengLiu TanzeHu JiweiLiu HeheLi LiangWang Jiwen