Ask about this productRelated genes to: RAB2A antibody
- Gene:
- RAB2A NIH gene
- Name:
- RAB2A, member RAS oncogene family
- Previous symbol:
- RAB2
- Synonyms:
- -
- Chromosome:
- 8q12.1-q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-22
- Date modifiied:
- 2018-02-13
Related products to: RAB2A antibody
Related articles to: RAB2A antibody
- Cytogenetics analysis of adipocytic tumours revealed varieties of chromosomal translocations beyond MDM2 amplification, so, this report aimed to identify these translocations and recognise the altered genes with their fusion partners. - Source: PubMed
Atta I SShafek S IAbdel-Hamid M - PLAG1 gene fusions have been identified in a subset of uterine sarcomas and were historically associated with myxoid morphology. However, recent evidence shows that not all cases demonstrate myxoid features or conventional smooth muscle immunophenotype. Herein, we present 11 cases of PLAG1-rearranged uterine mesenchymal tumours to further characterize their clinicopathologic, immunohistochemical and molecular profiles. - Source: PubMed
Publication date: 2026/04/22
Cai MengyuanZuo KeYu LinCheng YufanBi RuiGe HuijuanYang WentaoTu Xiaoyu - Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates systemic metabolism. Here, we delineate a novel regulatory pathway for FGF21 orchestrated by the small GTPase Rab2A. Our previous findings demonstrated that liver-specific deficiency of Rab2A impairs very low-density lipoprotein lipidation and promotes apolipoprotein B (APOB) accumulation. We now show that accumulated APOB drives the cleavage and activation of cAMP-responsive element-binding protein H (CREBH), a key hepatic transcription factor for FGF21 expression. Mechanistically, hepatic Rab2A inhibition protected mice from high-fat diet-induced obesity and was associated with markedly elevated circulating FGF21, the phenotype largely rescued by adenovirus-mediated knockdown of either CREBH or APOB. Collectively, we define a Rab2A-APOB-CREBH axis that is potentially essential for the hepatic regulation of FGF21. - Source: PubMed
Publication date: 2025/11/26
Chen Zi-YueXu MinChen ShuaiChen Liang - Mammalian fertilization begins with the species-specific binding of spermatozoa to the oocyte's zona pellucida (ZP), a process mediated by multiple surface proteins forming a functional receptor complex. Among them, the Ras oncogene family protein RAB2A and lactadherin/MFGE8 (p47/SED1) were previously identified as ZP-binding candidates in pig; however, their functional roles in sperm-oocyte interactions remained unconfirmed. This study aimed to evaluate their involvement in sperm-ZP binding by using antibody-blocking and competitive binding assays with porcine oocytes. In parallel, we validated the specificity and functional relevance of two in-house raised monoclonal antibodies, 5C5 and 1H9, targeting RAB2A and lactadherin/MFGE8, respectively, and further characterized these proteins in boar spermatozoa. Immunofluorescence detection indicated that both RAB2A and lactadherin/MFGE8 became accessible on the sperm surface upon capacitation. Their surface localization at this stage supports their potential involvement in the primary sperm-ZP interactions preceding acrosomal exocytosis. Moreover, the sperm-specific 5C5 antibody detected reduced RAB2A levels in ejaculates from men with abnormal sperm parameters. This highlights the potential of RAB2A as a biomarker of sperm quality and acrosomal integrity, with promising translational relevance from animal models to humans. sperm-zona binding assays revealed that while in-house raised antibody treatments showed no significant inhibition, follow-up experiments using a commercial anti-RAB2A antibody demonstrated a significant reduction in sperm binding to the ZP of the oocyte. Both recombinant RAB2A (rc-RAB2A) and recombinant lactadherin (rc-lactadherin) significantly reduced sperm-ZP binding, highlighting their functional relevance. Our results support the role of RAB2A and lactadherin/MFGE8 in sperm-oocyte binding and highlight the utility of monoclonal antibodies 5C5 and 1H9 for sperm phenotyping. Future work should focus on identifying molecular interaction partners and signaling mechanisms that mediate the initiation of acrosomal exocytosis at fertilization. - Source: PubMed
Publication date: 2025/10/02
Zelenkova NatalieKraus VeronikaDed LukasSpevakova DanielaSadilkova LucieFrolikova MichaelaPilsova AnetaPilsova ZuzanaKlusackova BarboraSimonik OndrejChmelikova EvaKrejcova TerezaZigo MichalSutovsky PeterSedmikova MarketaKomrskova KaterinaPostlerova Pavla - Genome-wide association studies (GWAS) are rapidly advancing due to the improved resolution and completeness provided by Telomere-to-Telomere (T2T) and pangenome assemblies. While recent advancements in GWAS methods have primarily focused on identifying genetic variants associated with discrete phenotypes, approaches for quantitative traits (QTs) remain underdeveloped. This has often led to significant variants being overlooked due to biases from genotype multicollinearity and strict p-value thresholds. - Source: PubMed
Publication date: 2025/03/12
Sharma JyotiJangale VaishnaviShekhawat Rajveer SinghYadav Pankaj