Ask about this productRelated genes to: RAB23 antibody
- Gene:
- RAB23 NIH gene
- Name:
- RAB23, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6p12.1-p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-18
- Date modifiied:
- 2018-02-13
Related products to: RAB23 antibody
Related articles to: RAB23 antibody
- Diabetic retinopathy (DR) can significantly impair vision and lead to blindness. Vitamin D (VD) has been shown to enhance the production of anti-inflammatory factors, alleviating the effects of hyperglycemia. However, downstream genes and molecular networks associated with VD signaling in DR remain unidentified. This study aimed to employ a systems biology approach to nominate high-priority candidate genes and cellular contexts as a hypothesis-generating effort to facilitate future functional studies on the role of VD in DR. - Source: PubMed
Chen PengfeiLi RuiqiZhao KerenLiu RuiHao Yuhua - The ClinGen Craniofacial Malformations Gene Curation Expert Panel (Cranio GCEP) was formed in 2020 with an initial target of evaluating genes implicated in craniosynostosis and skull abnormalities. This work summarizes the findings of the Cranio GCEP during its first round of curation, aiming to provide expert guidance for clinical validity of gene-disease relationships in the context of craniofacial malformations. - Source: PubMed
Publication date: 2026/04/29
Edoh EnyonamMighton ChloeBroeren EleanorGitau VanessaRatliff JulieDiStefano MarinaGadalla SandraGirod AmandaHughes MadelineMcCurry HannahPatel MayherWilcox Emma HMohammadi MoosaPaschal CateSpector ElaineWilkie Andrew O MZackai ElaineZarate Yuri AGraham John MJabs Ethylin WangSanchez-Lara Pedro A - Human periodontal ligament mesenchymal cells (PDLCs) are promising for regenerative therapies but show heterogeneous osteogenic commitment that limits bone regeneration. To attempt to overcome this limitation, we focus on the Hedgehog (Hh) signaling pathway, which is crucial for osteoblastic differentiation as the mechanistic focus of the study and as a strategy to overcome this heterogeneous osteogenic commitment. Resveratrol, a naturally occurring polyphenol, exhibits osteoinductive properties, but its effects on osteogenesis in PDLCs with low osteogenic potential (l-PDLCs) remain unclear. We aimed to investigate whether resveratrol could activate the transcriptional program of Hh signaling in l-PDLCs, as the mechanistic focus of the study and as a strategy to overcome the heterogeneous osteogenic commitment, thereby enhancing mineralization in vitro. Cell viability and osteogenic potential were analyzed under different concentrations and treatment protocols. RNA sequencing, gene expression analysis, transcriptional correlation, and molecular docking were performed in l-PDLCs cultured for 10 days under osteogenic medium (OM) or pretreated for 3 days with resveratrol followed by 10 days of induction (OM/Resv). Pretreatment with 0.1 μM resveratrol exhibited a two-fold increase in mitochondrial metabolism and mineral deposition in vitro. Although multiple osteogenic pathways were modulated, Hh signaling was notably activated, with SHH, DHH, IHH, GLI1 and PTCH1 significantly enriched in OM/Resv compared to OM. Importantly, IHH and SP7 were upregulated and strongly correlated after resveratrol treatment. Resveratrol pretreatment during osteogenic induction upregulated GLI1, PTCH1, and SMO, while downregulating RAB23 (p ≤ 0.01), corroborating RNA-seq results. Molecular docking predicted 23 interactions between resveratrol and RAB23, a negative regulator of Hh signaling, suggesting competition with GDP at the RAB23 active site. Resveratrol enhanced proliferation and osteogenic differentiation in l-PDLCs. Activation of osteogenic markers via the Hh pathway and RAB23 downregulation suggests its role in bone regeneration. These findings provide insights into resveratrol-induced osteogenesis and support its potential as a bioactive modulator of osteogenic pathways in PDLCs for bone regenerative therapies. - Source: PubMed
Publication date: 2026/04/02
Ferreira Rogério Salinasde Assis Rahyza Inácio FreireRacca FrancescaBontempi Ana Carolinade Carvalho Anne Caroline Teles CamposWiench MalgorzataAndia Denise Carleto - Insect bite hypersensitivity (IBH) is a prevalent allergic skin disease in horses that significantly affects animal welfare and shows evidence of genetic predisposition. - Source: PubMed
Publication date: 2026/03/20
Błaszczak AOlczak KStefaniuk-Szmukier MTomczyk-Wrona IMusiał A DGrzegorczyk JDługosz BSzmatoła TRopka-Molik K - The proteins Inturned and Fuzzy are members of the tri-longin domain (TLD) RabGEF family and activate the GTPase Rab23 downstream of the core planar cell polarity (PCP) proteins Vangl2 and Prickle. To gain insight into the function of a predicted PDZ domain unique to Inturned among TLD proteins, we performed structural and biochemical characterisations. We show that this domain does not interact with membranes or Vangl2. Instead, we find a phosphorylation-dependent interaction between Vangl2 and a PDZ domain of the apical-basal polarity protein Scribble. A crystal structure of Intu-PDZ reveals a unique PDZ-like fold lacking an interaction site for PDZ-binding motifs. Our data provide new insight into the role of PDZ domains in coordinating cell polarity downstream of Vangl2. - Source: PubMed
Publication date: 2026/03/08
Wilmes StephanBrysch JanGelze CarmenMeier LilliKümmel Daniel