Ask about this productRelated genes to: RAB18 antibody
- Gene:
- RAB18 NIH gene
- Name:
- RAB18, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-12
- Date modifiied:
- 2016-10-05
Related products to: RAB18 antibody
Related articles to: RAB18 antibody
- Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. In the cardiovascular system, lipids serve as a primary energy source, and dysregulated lipid metabolism has been observed in many CVDs. Lipid droplets (LDs) are organelles that store lipids, including triglycerides and cholesterol. The biogenesis and lipolysis of LDs broadly influence lipid metabolism in cells in the cardiovascular system and contribute to CVDs. LDs homeostasis is modulated by lipid droplet-associated proteins (LDAPs), such as PLINs, CIDEs, BSCL2, ABHD5, and Rab18. These proteins have also been reported to be involved in various CVDs. To our knowledge, this is the first review to systematically elucidate the associations between LDAPs and CVDs. Here, we summarize the roles of LDAPs in CVDs and discuss them in detail. - Source: PubMed
Publication date: 2026/02/25
Yu ZhongyangZhao MengXu HongyueJin XiaoxingSun Ji - Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic protein subunit 2 (RAB3GAP2). The capillary-increasing G allele was more prevalent in elite endurance athletes than in power athletes and non-athlete controls in two independent cohorts. Low-muscle-expressing RAB3GAP2 expression quantitative trait locus (eQTL) alleles were associated with muscle damage in athletes. In healthy individuals, RAB3GAP2 expression was reduced by high-intensity intermittent training. RAB3GAP2 protein was not uniformly expressed in muscle but predominantly expressed in the endothelium and capillaries. RAB3GAP2 expression was lower in endurance compared with power athletes and was negatively associated with type I (oxidative) muscle fiber density. Experimental reduction of RAB3GAP2 in human endothelial cells led to (1) increased proliferation and tube formation in vitro, (2) regulation of secreted factors (e.g., CD70 and TNC) promoting angiogenesis and T cell activation, and (3) increased in vivo endothelial cell density in mice. RAB3GAP2 expression in skeletal muscle was negatively correlated with exercise-induced release of TNC in vivo in humans. In conclusion, RAB3GAP2 is expressed in the microvascular endothelium and is suggested to be a negative regulator of angiogenesis through a decrease in endothelial cell proliferation, possibly mediated by RAB18, with its low-expressing variant associated with higher muscle C:F and elite endurance performance. - Source: PubMed
Publication date: 2026/02/11
Ström KristofferOskolkov NikolayKaraderi TugceKalamajski SebastianMir Bilal AEkström OlaMiyamoto-Mikami EriLadenvall ClaesKakulidis EllenReid StevenDutius Andersson Anna-MariaKryvokhyzha DmytroZhang EnmingFadista JoaoThangam ManonanthiniIemitsu MotoyukiSemenova Ekaterina ALarin Andrey KSultanov Rinat IBabalyan Konstantin AZhelankin Andrey VKulemin Nikolay AGenerozov Edward VHultström MichaelFrithiof RobertZeberg HugoLipcsey MiklosLarsson AndersMahajan AnubhaAhlqvist EmmaPrasad Rashmi BPrüfer Kay Sabater-Lleal MariaSmith Nicholas LDehghan AbbasLind LarsMcGawley KerryMorris Andrew PAndersson Johan P ALehtovirta MikkoSzczerbiński ŁukaszKretowski AdamAhmetov Ildus IWang GuanPitsiladis YannisSantos-Lozano AlejandroLucia AlejandroFuku NoriyukiHolmberg Hans-ChristerGomez Maria FEriksson Karl-FredrikPietras KristianLindgren Cecilia MFranks Paul WHansson Ola - The augmentation of atmospheric CO concentrations induces reduction in foliar stomatal aperture, thereby affecting photosynthetic capacity and transpiration- mediated cooling in plants. Elucidating the mechanism through which CO modulates stomatal dynamics is crucial for understanding plant adaptability to future fluctuations in CO levels. Although abscisic acid (ABA) is a pivotal phytohormone regulating stomatal movements, its role in CO-induced stomatal closure remains unclear. Here, we demonstrate that elevated CO failed to induce stomatal closure in wild-type Arabidopsis treated with ABA biosynthesis inhibitor fluridon, as well as in the ABA-deficient mutant aba1, aba2 and aba3. Using β-glucuronidase (GUS) staining in pRD29B::GUS transgenic lines, we confirmed that the reporter gene controlled by ABA-responsive RD29B promoter in guard cells was strongly induced by elevated CO. Additionally, transcripts of the ABA-responsive gene RAB18 and ABA-synthetic gene ABA2 were upregulated during CO-induced stomatal closure in wild-type Arabidopsis. In contrast, fluridonand ABA receptor mutant pyr1pyl1pyl2pyl4 respectively inhibited CO-induced activation of RD29B promoter-driven GUS marker and RAB18 expression. The expression of green fluorescent protein (GFP) reporter gene driven by ABA2 and RAB18 promoters in tobacco leaves was enhanced under CO, and the fluorescence mainly distributed in non-guard cells. Furthermore, ABA, ABA receptor (PYR/RCARs) and OST1 kinase were identified as upstream cascade components of HO and NO in stomatal response to CO. Notably, GHR1 was implicated as an intermediate between HO and NO in this pathway. Additionally, NADPH oxidase subunits AtRBOHD and AtRBOHF, and nitrate reductase isoenzyme NIA1, were responsible for HO and NO production in guard cells under high CO conditions. Together, our findings propose that elevated CO triggers an increase in ABA and activates ABA signaling to close stomata via HO and NO production, providing comprehensive insights into CO signaling in guard cells. - Source: PubMed
Publication date: 2026/01/29
Li JinxiaZhang ChenxiMu MingtaoMa XiaoyuHei Shumei - Extra-large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation remain poorly understood. Here, we show that PI3K-Rab18-GDP signalling promotes the secretion of XLEVs from human mesenchymal stem cells (hMSCs) and fibroblasts. These vesicles are highly enriched in sonic hedgehog (SHH) and display potent pro-angiogenic activity. We further demonstrate that Rab18 functions as a key regulator of this pathway specifically in its GDP-bound form, which can be enriched by the Rab inhibitor CID1067700 or by pharmacological activation of PI3K using SF1670. Rab18-GDP preferentially accumulates in the perinuclear region, where it promotes the formation of SHH-XLEV precursors from endosomal compartments. Mechanistically, PI3K-Rab18-GDP signalling recruits heat shock protein 90α (Hsp90α) and neutral sphingomyelinase 2 (nSMase2), facilitating polarized release of SHH-XLEVs from the perinuclear-plasma membrane interface, accompanied by an Hsp90α-enriched extracellular assembly. Together, these findings identify a PI3K-Rab18-GDP-dependent secretory pathway for SHH-XLEVs and provide a framework for understanding how XLEV biogenesis is coupled to SHH-associated angiogenic signalling in developmental and regenerative contexts. - Source: PubMed
Publication date: 2026/01/28
Wang ShuoImai RioKaneko YuyaTanaka Yosuke - Rapeseed ( L.) productivity is increasingly threatened by drought, yet coordinated regulatory programs that govern drought responses remain incompletely characterized. Here, we integrated an RNA-Seq meta-analysis with weighted gene co-expression network analysis (WGCNA) and gene regulatory network (GRN) inference to study in depth the molecular responses of rapeseed to drought stress. WGCNA revealed three modules: brown module enriched for upregulated genes and two primarily downregulated modules (black and cyan). Brown-module hubs coordinate ABA signaling, stomatal regulation, lipid mobilization, cell-wall reinforcement and protein homeostasis, whereas black and cyan module hubs converge on suppression of growth, defense and metal-detoxification pathways and reallocation of resources away from reproduction. Furthermore, this study identified crucial hub transcription factors (TFs) within constructed GRNs. Upregulated TFs orchestrated the induction of downstream genes involved in ABA signaling, protein homeostasis, antioxidant and redox maintenance, stomatal, calcium, and ion regulation, membrane, cell wall, and lipid remodeling, photosynthetic processes, and developmental reprogramming. Conversely, TFs in the downregulated GRN repress growth-promoting signals, stomatal opening, and defense responses, while concurrently regulating water use efficiency, water transport, and nutrient uptake. Our results suggest that the ABA-mediated drought response in rapeseed involves an intricate interplay of positive and negative regulators that prevents excessive ABA activation; concurrently, protein homeostasis is maintained by prioritizing repair and refolding over wholesale degradation. Several TFs and hub genes identified in this study, including , , , , , , and , represent promising candidates for genomic selection and biotechnology approaches aimed at improving drought resilience in rapeseed. - Source: PubMed
Publication date: 2025/12/30
Shahsavari MasoudRaspor MartinMohammadi Valiollah