Ask about this productRelated genes to: QDPR antibody
- Gene:
- QDPR NIH gene
- Name:
- quinoid dihydropteridine reductase
- Previous symbol:
- -
- Synonyms:
- DHPR, PKU2, SDR33C1
- Chromosome:
- 4p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: QDPR antibody
Related articles to: QDPR antibody
- Molecular glues are small molecules that engage their target and presenter proteins cooperatively. FKBP12 molecular glues (FK506 and rapamycin) were discovered several decades ago and have been used clinically, but our understanding of the breadth of FKBP12 molecular glues and targets has yet to be fully revealed. To expand the target classes of FKBP12 molecular glues, we construct and screen a multi-million-member non-macrocyclic FKBP12-ligand DNA-encoded library using 25 structurally distinct proteins. Synthesis and validation of select hits in biophysical and cell-based assays confirm FKBP12-dependent molecular-glue recruitment to bromodomain-containing protein 9 (BRD9) and quinoid dihydropteridine reductase (QDPR). One glue shows no measurable binding to QDPR alone but has appreciable binding in the presence of FKBP12 using either purified proteins or intact cells. The sites of recruitment are characterized with mutational analysis, competition-based methods and X-ray crystallography. The results of this study confirm that FKBP12-binding DELs can yield molecular glues generating highly selective FKBP12-target protein interactions. - Source: PubMed
Publication date: 2026/04/22
Zandi Trevor ARomanowski Michael JViscomi Jessica SGunderson KarlTan Zher YinTong BingqiBonazzi SimoneZécri Frédéric JSchreiber Stuart LMichaud Gregory A - Advanced renal failure remains a major global health burden. Mitochondrial dysfunction is frequently observed during progressive kidney injury and chronic allograft dysfunction (CAD), but observational data cannot distinguish causal involvement from secondary consequences. We applied a multi-omic genetic prioritization framework to evaluate whether inherited variation affecting mitochondrial gene regulation is associated with a proxy phenotype for advanced renal failure and fibrotic allograft remodeling. - Source: PubMed
Publication date: 2026/03/27
Shen QinghuanDing RunminWen ZhiyuFeng DengyuanZhang JianjianLiu JiawenHan QianguangSun LiChen HaoFei ShuangXu ZhenHao RuijinlinTan Ruoyun - The production of complex biologics in Chinese hamster ovary (CHO) cells is constrained by the lack of selection systems capable of coordinating multiple transgenes. Conventional single-marker systems have low saturable thresholds that limit enrichment efficiency, while multi-auxotrophic platforms often impose metabolic burdens. Here, we present a rationally designed tyrosine-auxotrophic system that overcomes these limitations by establishing a high-threshold cooperative selection mechanism. This is achieved through the reconstruction of an essential pathway comprising pterin-4α carbinolamine dehydratase 1 (PCBD1), phenylalanine hydroxylase (PAH), and quinoid dihydropteridine reductase (QDPR). We generated a triple-knockout CHO host via CRISPR/Cas9, wherein survival under tyrosine deprivation became strictly dependent on the balanced co-expression of all three rescue genes. This architecture creates a selection pressure that is not saturable by any single gene, enabling efficient co-enrichment. Applied to monoclonal antibody (mAb) production, the system enriched triple-positive populations to 97.49%, resulting in significantly enhanced homogeneity and coordinated upregulation of antibody chain expression. Optimized pools achieved titers of 0.35 g/L in fed-batch and 1.60 g/L in perfusion cultures without tyrosine feeding. Consequently, pathway reconstitution rewired central metabolism, reducing byproducts and enhancing biosynthesis. This antibiotic-free multi-marker platform establishes a new paradigm for stringent multigene co-expression, advancing CHO cell engineering for next-generation biologics. - Source: PubMed
Publication date: 2026/03/09
Cao LeiNa DaoyuanCheng JunZhao LiangYe QianTan Wen-Song - The global incidence of Hyperphenylalaninemia (HPA) demonstrates significant geographical variations, exhibiting distinct regional and ethnic characteristics in both phenotypic manifestations and genotypic profiles. To date, there remains a paucity of data regarding the genotype-phenotype correlation in pediatric patients with phenylalanine hydroxylase deficiency (PAHD) from Southwest China. This study aims to conduct a retrospective analysis of neonatal HPA prevalence and characterize PAH gene mutations in Yunnan Province in Southwest China. These findings are expected to establish an evidence base for optimizing clinical follow-up protocols, facilitating genetic counseling, and enabling prenatal molecular diagnosis for affected children. - Source: PubMed
Publication date: 2025/11/25
Wang QiongDuan JiangZhao XiaolongQi Zhiye - Incorporating perovskite quantum dots (PQDs) into photoresist (PR) and utilizing mature photolithography processes is an optimal strategies for achieving patterning, perfectly aligning with the requirements for large-scale manufacturing. Consequently, enhancing the intrinsic stability of the red-emitting CsPbBrI QDs is paramount to enable their direct mixing with PR for subsequent lithographic processing. Herein, a B-site-doped CsPbBrI QD is designed by introducing Sr⁺. This doping enhances the lattice stability and partially repairs surface defects. The Sr-doped CsPbBrI QDs solution maintains stability for 30 days, retaining 93.7% of its initial photoluminescence (PL) intensity with a PL peak barely shift, while the films show enhanced thermal tolerance. Owing to the high stability, the Sr-doped CsPbBrI QDs are mixed with commercial PR, and the blend maintained a photoluminescence quantum yield (PLQY) of 61%. Photolithographic patterned films achieve the minimum feature size of 88.39 µm with better uniformity and luminescence intensity. Encapsulated within the PR matrix, the QD-PR films confer exceptional water stability, retaining strong luminescence even after 48 h immersion, and resistance to polar solvents. Sr-doped CsPbBrI QDs and the commercial PR synergistically overcome compatibility barriers, facilitating simple and efficient photolithographic patterning. - Source: PubMed
Publication date: 2025/11/25
Wang BinLi MulinYou JunyiZhang FengyiLv RongqiuWang WeiweiZhou WenbinChen JunZeng Haibo