Ask about this productRelated genes to: PYGB antibody
- Gene:
- PYGB NIH gene
- Name:
- glycogen phosphorylase B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1988-06-27
- Date modifiied:
- 2016-10-13
Related products to: PYGB antibody
Related articles to: PYGB antibody
- Glycolytic reprogramming has been implicated in rheumatoid arthritis (RA) pathogenesis, yet the underlying causal genes and epigenetic mechanisms remain unclear. This study aimed to systematically identify glycolysis-related genes and their methylation-regulated expression that may causally influence RA susceptibility. - Source: PubMed
Publication date: 2026/01/22
A XinyuXin PengfeiZheng LinXu BoWang JianyeSun SongtaoXie JunGao ChenxinPan PeijunQiu GuoweiJin LangShen JunXu XiruiCheng YiweiPei ShaoqiangRan LeiBian YanqinXiao Lianbo - In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to cognitive decline in neurological diseases, they remain largely unstudied in the context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes in the aged hippocampus, with substantial variation among 32 inbred BXD mouse strains. Genetic mapping through quantitative trait locus analysis identified a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic and proteomic datasets were produced for the aged hippocampus of the BXD family to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences PGB burden through trans-regulation of mRNA and protein expression levels, including abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide association scans, transcriptomic analyses, and direct behavioral testing demonstrated that cognition remains intact despite age-related PGB burden. A record of this paper's transparent peer review process is included in the supplemental information. - Source: PubMed
Publication date: 2026/02/02
Gómez-Pascual AliciaGlikman Dow MNg Hui XinTomkins James ELu LuXu YingAshbrook David GKaczorowski CatherineKempermann GerdKillmar JohnMozhui KhyobeniOhlenschläger OliverAebersold RudolfIngram Donald KWilliams Evan GJucker MathiasOverall Rupert WWilliams Robert Wde Bakker Dennis E M - Lung squamous cell carcinoma (LUSC) is a common and aggressive malignancy. Necroptosis, a regulated mode of cell death, has been implicated in tumor immunity and oncogenic processes, yet the mechanistic involvement of necroptosis-related genes (NRGs) in LUSC pathogenesis remains unclear, necessitating systematic evaluation of their biological and clinical relevance. - Source: PubMed
Publication date: 2025/10/29
Sun KaiWang Ke-RunWen SongHong Juan-JuanFei Yu-LangPan Qing-HuaXie Fang-Fang - Maternal care is an instinctive social behavior indispensable for survival and gene transmission. Postpartum maternal behavior is profoundly affected by mother's emotional state via incompletely elucidated complex mechanisms including metabolic regulation. Brain glycogen, primarily located in astrocytes, is a potent modulator for brain plasticity and provides neuroprotection against bioenergetic insults. The regulation of brain glycogen is of relevance to hormonal control that might be linked to sex-dimorphic responses in mental health. The present study aims to investigate the involvement of glycogen in the sex differences of brain structural plasticity, and to characterize the impacts on affective and maternal behaviors in both sexes. - Source: PubMed
Publication date: 2025/06/11
Shi XiaotongZhu YuanyuanZhang ZhaoyichunMa NingcanHe DanyiWu YouDai ZiyiQin XinyanChen YingyiZhao YouyiZhang HaopengHuang JingZhang HuiFan Ze - Brain glycogen phosphorylase (PYGB) facilitates the breakdown of glycogen, thereby supplying energy to tumor cells. While PYGB expression has been documented in various tumor types, its specific function in lung cancer (LC) remains to be elucidated. This study aims to explore the potential involvement of PYGB in the initiation and progression of LC. - Source: PubMed
Publication date: 2025/05/19
Sun KaiXu De-ChangQin XiaXie Fang-Fang