Ask about this productRelated genes to: PTP4A1 antibody
- Gene:
- PTP4A1 NIH gene
- Name:
- protein tyrosine phosphatase 4A1
- Previous symbol:
- -
- Synonyms:
- PTPCAAX1, PRL-1, PRL1
- Chromosome:
- 6q12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-02
- Date modifiied:
- 2019-02-14
Related products to: PTP4A1 antibody
Related articles to: PTP4A1 antibody
- Alcoholic liver disease (ALD), secondary to chronic alcohol abuse, encompasses a spectrum of liver disorders that progress from steatosis and hepatitis to fibrosis, cirrhosis, and acute-on-chronic liver failure. It poses a considerable global health burden due to its elevated rates of associated morbidity and mortality. The rising prevalence of ALD, coupled with the lack of approved pharmacotherapies, presents considerable unmet clinical needs. In this study, long-chain acyl-CoA synthetase 4 (ACSL4) was identified as a pathogenic driver in the context of chronic alcohol consumption. Hepatocyte ablation mitigated key pathological manifestations in Gao-Binge model mice, as evidenced by reduced inflammatory cell infiltration and attenuated lipid accumulation. Mechanistically, ACSL4 inhibition augmented cellular antioxidant defence through elevating gamma-glutamylcysteine (γ-GC) levels. In addition, γ-GC bound to and suppressed the expression of protein tyrosine phosphatase type IVA member 1 (PTP4A1). Both genetic silencing and pharmacological inhibition of PTP4A1 attenuated the activation of the downstream MAPK-NF-κB inflammatory cascade. Dronedarone, identified as a novel compound targeting ACSL4, demonstrated efficacy in ameliorating the progression of ALD. Overall, these findings elucidate a novel mechanism wherein ACSL4 modulates antioxidant responses via a small bioactive peptide, highlighting ACSL4 as a potential therapeutic target for ALD. - Source: PubMed
Publication date: 2026/03/31
Duan RanWang Xin-YiZhou XueDing Jing-WenYang Zhi-SenLi Zhi-LinWang Yue-YuYu Jia-XinDuan Jing-Jing - Insect bite hypersensitivity (IBH) is a prevalent allergic skin disease in horses that significantly affects animal welfare and shows evidence of genetic predisposition. - Source: PubMed
Publication date: 2026/03/20
Błaszczak AOlczak KStefaniuk-Szmukier MTomczyk-Wrona IMusiał A DGrzegorczyk JDługosz BSzmatoła TRopka-Molik K - Cancer predominantly affects older individuals, with age being a significant risk factor for cancer incidence and metastasis. Biological sex also plays a crucial role in influencing metastasis and survival outcomes. In colorectal cancer (CRC), both the incidence and mortality from metastatic disease are higher in males relative to females. - Source: PubMed
Publication date: 2025/11/08
Wang ZhikunLiu YueyingYang JingHilliard Tyvette SSafavi-Sohi ReihanehHu Daniel DHarper Elizabeth IDominique GenaWang WanruiJohnson JeffreyAsem MarwaMilosevich WilliamCarlson Julia FlorekBai YunpengMiao JinminZhang Zhong-YinChampion Matthew MSharon Stack M - Colorectal cancer (CRC) manifests as a prevalent malignancy marked by distinct gene expression patterns. In the intricate landscape of cancer development, non-coding RNAs, particularly long non-coding RNAs (lncRNAs), exert a substantial influence. This research aimed to investigate the expression patterns of the antisense long non-coding RNA (lncRNA), LENG8-AS1, and its consequential impact on the survival outcomes of patients diagnosed with CRC. Utilizing TCGA data and the TCGA Biolinks packages, a comprehensive analysis was conducted to identify potential lncRNA candidates implicated in CRC. The clinical data underwent Cox regression analysis to evaluate the correlation between the expression levels of selected lncRNAs, including LENG8-AS1, and the survival rates of patients. The predictive model of survival rates was visually represented through Kaplan-Meier plots. To validate the findings, real-time quantitative polymerase chain reaction (RT-qPCR) was performed on CRC samples and adjacent normal tissues. Data revealed that several lncRNAs, including CAPN10-AS1 and LENG8-AS1, associated with poor prognosis, while AC016027.1 and PTP4A1-AS1 were linked to better prognosis. Kaplan-Meier analysis supported the potential of these lncRNAs as prognostic markers for CRC. LENG8-AS1, a less-studied lncRNA in CRC, was found to be upregulated and was correlated with genes involved in lipid metabolism and angiogenesis pathways. RT-qPCR confirmed the increased expression of LENG8-AS1 in CRC samples. Additionally, ROC curve analysis demonstrated the potential of LENG8-AS1 as a valuable biomarker for CRC. Overall, these findings suggest that LENG8-AS1 may serve as a biomarker for CRC, with its increased expression being associated with tumor progression and poor patient prognosis. - Source: PubMed
Publication date: 2024/05/27
Jafarnia PardisMahdevar MohammadPeymani Maryam - The GINS complex subunit 2 (GINS2) is crucial for DNA replication, but its specific roles in oral squamous cell carcinoma (OSCC) pathogenesis and tumor microenvironment (TME) modulation are poorly defined. - Source: PubMed
Publication date: 2025/11/05
Wei BoYin JiajiaShi ChuyanSun HuiLiu BingChen Peng