Ask about this productRelated genes to: PTH2R antibody
- Gene:
- PTH2R NIH gene
- Name:
- parathyroid hormone 2 receptor
- Previous symbol:
- PTHR2
- Synonyms:
- -
- Chromosome:
- 2q34
- Locus Type:
- gene with protein product
- Date approved:
- 1996-03-19
- Date modifiied:
- 2016-10-05
Related products to: PTH2R antibody
Related articles to: PTH2R antibody
- : One of the main causes of cancer-related mortality globally is lung adenocarcinoma (LUAD), necessitating the development of novel therapeutic targets. The parathyroid hormone type 2 receptor (PTH2R) exhibits differential expression across multiple cancers, yet its role in LUAD remains unclear. : Through an integrated analysis of multiple public databases (including SangerBox 3.0, UALCAN, Kaplan-Meier Plotter, and TIMER), we identified PTH2R-a member of the family B1 GPCRs-as a candidate therapeutic target with significant prognostic value in LUAD. Subsequently, the antitumor effects of PTH2R knockdown and melatonin were evaluated through cell proliferation, colony formation, migration, and apoptosis assays. Transcriptome analysis revealed key biological processes and signaling pathways regulated by PTH2R, identified key genes modulated by PTH2R, and validated core gene expression via RT-qPCR. : PTH2R is a potential therapeutic target for lung adenocarcinoma. Both PTH2R knockdown and melatonin treatment significantly inhibited LUAD cell proliferation, colony formation, and migration capabilities while promoting apoptosis. Notably, the combination of PTH2R knockdown and melatonin treatment demonstrated synergistically enhanced antitumor effects. Transcriptome analysis revealed two key genes within the PTH2R signaling pathway, and RT-qPCR validated the expression of these two key genes. : Our work provides the first evidence confirming the substantial value of PTH2R as a novel therapeutic target for LUAD. It preliminarily demonstrates the mechanism by which melatonin inhibits LUAD by targeting PTH2R, offering crucial experimental evidence and theoretical support for developing precision therapeutic strategies against this cancer. - Source: PubMed
Publication date: 2026/02/23
Liu ChangminWang YongfuLiu WeiYuan YizhenXue YajingTao PengzhuoSun DanKian Keong TeChen ShilinSong Chi - The tuberoinfundibular peptide of 39 residues (TIP39) is a small peptide first extracted in 1997, which has garnered limited research attention. It belongs to the parathyroid hormone (PTH)-related peptides family and specifically binds the parathyroid receptor type 2 (PTH2R). It is gaining attention for its roles in mood regulation, maternal behavior, and social functions. Its potential in modulating these processes possibly positions TIP39 as an underexplored candidate for exploring complex physiological functions of postpartum depression. - Source: PubMed
Publication date: 2026/01/08
Wang SilinLiu HongchiTang QiuyiLiao NingLiu TianhaoYang ZhengzhongWei YanghuiFu Rao - This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs, and genotyping was performed using a 50K SNP array. After stringent quality control and genotype imputation, approximately 4,697,453 high-quality autosomal variants were retained for subsequent genome-wide association study (GWAS), transcriptome-wide association study (TWAS), and phenome-wide association study (PheWAS). The GWAS identified four genome-wide significant loci, including rs343276492 and rs321308815. TWAS results revealed that the expression level of PTH2R was significantly associated with pituitary-related traits. In addition, selection signal analysis identified multiple genomic regions related to growth, development, and environmental adaptability, which were significantly enriched in pathways such as circadian rhythm regulation and the MAPK signaling pathway. These pathways play critical roles in growth regulation and adaptive evolution in Wanyue Black pigs. Collectively, this study provides valuable candidate genes and potential molecular markers for the genetic improvement and breeding of Wanyue Black pigs. - Source: PubMed
Publication date: 2025/12/31
Ye HaiboLi WeiTian FangWang QianqianMa ZhonghuaGuan JinyuDing YueyunZheng XianruiYin ZongjunZhang Xiaodong - Depression, a common neuropsychiatric disorder, profoundly disrupts individuals' daily lives. Although the pathogenesis of depression is intensively investigated for decades, its underlying mechanisms remain elusive. Here, dysfunctional adenylyl cyclase 8 (Adcy8) is identified as a critical risk factor for the development of depression. Adcy8 expression is selectively decreased in the hippocampus, but not in the cortex, thalamus, and hypothalamus, of mice exposed to chronic stress. Adcy8 conditional knockout (CKO) in excitatory neurons, particularly dorsal CA1 (dCA1) neurons, resulted in pronounced depressive-like behaviors. Depletion of Adcy8 in dCA1 neurons reduces neuronal excitability and glutamatergic neurotransmission. Further mechanistic studies reveal a remarkable inhibition of the mitogen-activated protein kinase (MAPK) signaling pathway by Adcy8 CKO, which downregulates parathyroid hormone 2 receptor (PTH2R) level in the hippocampus. Knocking down Pth2r with AAV-shRNA duplicates the impairments in neuronal excitability, glutamatergic neurotransmission and depressive-like behaviors. In contrast, overexpression of PTH2R in Adcy8 CKO hippocampus rescues these deficits. Chronic infusion of TIP39, the endogenous ligand for PTH2R, into the hippocampus also alleviates depressive-like behaviors of Adcy8 CKO mice. Taken together, these results uncover critical roles of Adcy8 in suppressing depressive-like behaviors, likely by maintaining the excitability and glutamatergic neurotransmission of dCA1 neurons through TIP39-PTH2R signaling pathway. - Source: PubMed
Publication date: 2025/12/12
Liu Zi-JieBi Jia-RuiYu Zong-YanTian MengChen Zhi-YueWei RanWang Miao-MiaoZha Hai-WeiZhang Yu-QingWang Hong-JingQiang Bang-YouSun Shuang-ShuangZhu Xiao-JuanChen Wen-BingSun Dong - Reproductive and growth traits are key economic traits in sheep. This study aims to identify key single nucleotide polymorphisms (SNPs) and candidate genes associated with reproductive and growth traits in Tianmu polytocous sheep through a genome-wide association study (GWAS). The findings are expected to provide both a theoretical foundation for molecular breeding in this breed and novel insights into the genetic basis of ovine reproductive and growth performance. This study took 483 adult Tianmu polytocous ewes as the research subjects, collected their lambing records, measured their phenotypic values of growth traits (3 weight and 11 body size traits), and collected their blood samples for whole-genome resequencing to identify SNPs in the Tianmu polytocous sheep genome. The results identified a total of 9,499,019 (3× coverage) and 27,413,216 (30× coverage) high-quality SNPs in the Tianmu polytocous sheep genome. Subsequently, the association analysis between SNPs and reproductive and growth traits was conducted using a mixed linear model. A total of 92, 66, 18, 28, 6, 42, 3, 3, 6, 1, 12, 3, 22, 8, 6, and 3 SNPs were found associated with litter size at first parity, litter size at second parity, litter size at third parity, litter size at fourth parity, birth weight, weaning weight, body height, withers height, body length, head length, head width, cannon bone circumference, forelimb height, chest girth, chest depth, and withers width, respectively. Further, based on SNP annotation, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, candidate genes associated with the reproductive and growth traits were identified. Among these genes, 11 , , , , , , , , and are candidate genes associated with litter size at first parity or litter size at third parity. These genes are involved in the G protein-coupled receptor signaling pathway, G protein-coupled receptor activity, ovarian tissue development, and hormone secretion. Additionally, and are candidate genes associated with birth weight, while five and are candidate genes associated with weaning weight. These candidate genes are primarily involved in lipid metabolism. Finally, the following genes were identified as candidates associated with specific traits: , , and with body height; and with body length; with cannon bone circumference; four genes with forelimb height; with chest depth; and with withers width. - Source: PubMed
Publication date: 2025/10/20
Liu WennaMa ShengchaoLu QingweiTang SenMamat NuraminaWang YaqianHong WeiHu XiangrongWu CuilingFu Xuefeng