Ask about this productRelated genes to: PSMB9 antibody
- Gene:
- PSMB9 NIH gene
- Name:
- proteasome subunit beta 9
- Previous symbol:
- LMP2
- Synonyms:
- RING12, beta1i, PSMB6i
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-18
- Date modifiied:
- 2016-10-05
Related products to: PSMB9 antibody
Related articles to: PSMB9 antibody
- Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by progressive joint destruction and functional impairment. Increasing data indicate that glutamate metabolism is critically involved in RA pathogenesis. This analysis aimed to identify glutamate metabolism-related biomarkers and potential RA therapeutics. - Source: PubMed
Publication date: 2026/04/29
Zhu BingruiLi BaoliangZhang ShuxuQi WenzhuoMu ZhouKong PengHan YingguangShi Zhigang - Gene regulatory networks differ substantially across individual cell lines, and population-level network inferences often fail to capture the underlying biological heterogeneity. To better capture this heterogeneity, cell line-specific gene network analysis is required. However, interpreting such high-dimensional cell line-specific networks remains a major challenge in the field of network biology. One interpretative approach is to identify differentially regulated gene networks (DGNs) between phenotypes because these networks can highlight phenotype-specific regulatory mechanisms. Although several methods have been proposed for DGN analysis, they are not suitable for cell line-specific gene network analysis, which is characterized by pronounced heterogeneity across individual networks. To address this problem, we proposed a novel statistical method for identifying DGNs in a cell line-specific scenario. The proposed framework integrates cell line-specific network estimation, a Kullback-Leibler divergence-based comparison of multivariate distributions, and a DKL-ratio statistic to quantify between-phenotype heterogeneity relative to within-phenotype homogeneity. Our method evaluates both between-phenotype heterogeneity and within-phenotype homogeneity, ensuring the robust detection of phenotype-specific network structures. Through Monte Carlo simulation studies, we systematically evaluated the performance of the proposed method and demonstrated that our strategy consistently outperformed existing methods in terms of accuracy, precision, true positive rate (TPR), true negative rate (TNR), and F-measure across diverse network structures and mean shift scenarios. Statistical significance was assessed using a permutation-based framework, confirming that the identified networks are unlikely to arise from random variation. We further applied our strategy to Quizartinib sensitivity-specific gene network analysis and identified immune-related subnetworks enriched in antigen processing and presentation pathways. These subnetworks included hub genes such as IFIT1, PSMB9, and HLA-B, which are known to be associated with immune evasion and drug resistance in acute myeloid leukemia. Our findings demonstrate that the proposed method enables statistically reliable and biologically interpretable identification of phenotype-specific gene regulatory mechanisms, providing insights into potential therapeutic targets. - Source: PubMed
Publication date: 2026/04/27
Oh JooeePark Heewon - Proteasome subunit beta type-9 (PSMB9) is a catalytic subunit of the immunoproteasome and plays an essential role in antigen processing and MHC class I (MHC I)-restricted cellular immunity in mammals. However, the role of PSMB9 in fish antiviral immunity remains poorly understood. In this study, we cloned and characterized the PSMB9 homologue from orange-spotted grouper (Epinephelus coioides), designated EcPSMB9, and investigated its potential role in host defence against Singapore grouper iridovirus (SGIV) and red-spotted grouper nervous necrosis virus (RGNNV). EcPSMB9 overexpression was consistently associated with reduced viral burden during both SGIV and RGNNV infection. In parallel, EcPSMB9 overexpression was accompanied by decreased GFP-LC3 puncta formation, lower LC3-II protein levels, and reduced expression of ATG5, ATG12, and ATG16, together with enhanced MHC I-associated and interferon-associated transcriptional activity, suggesting that EcPSMB9 may participate in antiviral defence through coordinated changes in proteostasis-related and antigen presentation-associated processes. Notably, structural modeling and co-immunoprecipitation analyses revealed an association between EcPSMB9 and the core immunoproteasome subunit EcPSMB8. Together, these findings suggest that EcPSMB9 is a conserved immunoproteasome subunit linked to antiviral responses in grouper and indicate that immunoproteasome subunit cooperation may be relevant to teleost antiviral immunity. - Source: PubMed
Publication date: 2026/05/12
Chen JinpengHe XinLi ShenHe YuhuiWei ShinaSun YunQin QiweiYang Min - Understanding the molecular mechanisms of host-parasite interaction remains a central challenge in fish immunology. This study presents the first transcriptomic analysis of the head kidney-a primary immune organ in teleost fish - in the Baikal omul (Coregonus migratorius) naturally infected with plerocercoids of the cestode Dibothriocephalus dendriticus. RNA-Seq data were generated and used to perform a de novo assembly of head kidney transcriptomes from infected and uninfected fish, followed by differential gene expression analysis. We identified a complex immune response characterized by the activation of pattern recognition receptors (PRRs), including C-type lectin receptors (CLRs), NOD-like receptors (NLRs), and Toll-like receptors (TLRs). KEGG pathway enrichment and DGE analysis revealed significant upregulation of pro-inflammatory signaling cascades (e.g., IKBKE, IRF5), antigen presentation components (e.g., PSMB9, MR1), as well as adapter and immunoregulatory molecules (e.g., GRAP2, TMIGD2, CD22). Concurrently, a selective down-regulation of several effector genes of both adaptive and innate immunity (e.g., IGHV, VLIG1, FCGR1A) was observed, indicating a suppression of energetically costly immune programs. GO analysis revealed significant enrichment of processes related to innate immune response, negative regulation of transcription and cell proliferation, as well as proteostasis control systems, accompanied by remodeling of the cellular component profile. These data suggest a strategy of controlled immune activation in C. migratorius, aimed at establishing long-term equilibrium with the parasite while minimizing energetic costs and immunopathology. This study expands fundamental knowledge of coregonid immunology and provides a foundation for investigating the molecular mechanisms of resistance to tissue-dwelling helminth infections. - Source: PubMed
Publication date: 2026/04/25
Mazur Olga EvgenievnaKutyrev Ivan AlexandrovichSidorova Tuyana ValeryevnaSukhanova Lubov Vasilyevna - 2',2',4',4'-Tetrabromodiphenyl ether (BDE-47), the most widespread congener of polybrominated diphenyl ethers, has attracted considerable attention due to its environmental persistence and extensive use. Although epidemiological data associate BDE-47 exposure with increased cancer risk, its role in bladder cancer (BC) remains insufficiently characterized. We found that BDE-47 at a physiologically relevant concentration (0.1 μM, comparable to human exposure levels) enhanced malignant phenotypes of BC cells in vitro. A total of 229 candidate genes were uncovered at both bulk and single-cell transcriptomic levels through weighted gene co-expression network analysis and its single-cell extension. Functional enrichment revealed prominent involvement in inflammatory regulation, extracellular matrix remodeling, and lipid metabolism pathways, further supported by transcriptome analysis of BDE-47-treated BC cells. Protein-protein interaction network construction combined with machine learning identified eight hub genes (ACSL4, IFIH1, JAK2, PSMB9, ACSL5, SOCS3, SREBF1, and JUN) as core targets of BDE-47-driven BC progression. Molecular docking suggested favorable predicted interactions between BDE-47 and these targets. A nomogram was constructed within the TCGA-BLCA cohort to visualize the prognostic model. Collectively, our findings provide a preliminary delineation of candidate targets and pathways potentially involved in BDE-47-associated bladder cancer progression, thereby offering a rationale for further mechanistic investigations. - Source: PubMed
Publication date: 2026/04/23
Sun MinghuiHu DichaoLi TongjieChen ZepingCong BoXi ZhenWang YongchenGuo RulinZhuo JianWu WenboLiu Haitao