Ask about this productRelated genes to: PSMB2 antibody
- Gene:
- PSMB2 NIH gene
- Name:
- proteasome subunit beta 2
- Previous symbol:
- -
- Synonyms:
- HC7-I
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-03
- Date modifiied:
- 2016-10-05
Related products to: PSMB2 antibody
Related articles to: PSMB2 antibody
- Sepsis is a life-threatening systemic inflammatory syndrome with limited targeted therapeutic options. Handelin, a natural compound derived from Chrysanthemum indicum, exhibits anti-inflammatory activity, yet its direct targets and protective mechanisms in sepsis remain unclear. - Source: PubMed
Publication date: 2026/03/19
Chen DexiuZhang QianWu YuanxinHu YingchunChen Muhu - Neddylation modifications in immune and tumor cells are linked to poor tumor prognosis. This study identifies prognostic genes associated with neddylation-related genes (NRGs) in colorectal cancer (CRC) using single-cell and spatial transcriptome (ST) sequencing, aiming to advance CRC treatment strategies. - Source: PubMed
Publication date: 2025/12/24
Zhu ZimingZhang XinyueWang SongHuang YunsiHan XuedongLai DongpingYao XinLan WeixuanNong HuiZeng WenbinMo YanhuaXu Ri'anZhang Tao - Nasopharyngeal carcinoma (NPC), highly prevalent in southern China, often leads to treatment failure in advanced stages due to recurrence or metastasis. While METTL14 plays a crucial role in cancer, its regulation of immune- and inflammation-related genes remains poorly understood. This study aims to investigate whether METTL14 is involved in regulating the expression of genes associated with tumor necrosis factor (TNF), interferon (IFN), interleukin (IL), and MHC class I in NPC cells. - Source: PubMed
Zhou ZhihaoWang JingShen LingjunHan LiuxinLi QiwenWu AibingLi JingLiang ZumingZhu LitongHe DanhuaZhou YingHuang ShihaoZhao ZhanlinCong JingePeng ZhitaoZhao PingYe ShunaBai BinyiHong XuanjiaDai GuanqiLei YeZhao WentaoJia JunshuangLin XiaolinXiao DongZhang YuqinLin Taoyan - Classical swine fever virus (CSFV), a highly virulent member of the genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this process remain obscure. The Core protein, functioning as the viral nucleocapsid, plays a pivotal role in the uncoating cascade. This study delineates a SUMOylation-dependent, ubiquitin-independent proteolytic mechanism essential for CSFV uncoating. The valosin-containing protein (VCP/p97) preferentially associates with SUMO1-modified Core, directing it toward degradation via the 26S proteasome, specifically through engagement with PSMB2 and PSMD2 subunits. Site-directed mutagenesis of the SUMOylation motif abolishes VCP-mediated degradation, substantiating its functional indispensability. Fluorescent tracking of CSFV virions using molecular beacon and quantum dot labeling further reveals that VCP governs the endosomal trafficking of viral particles from early to late endosomes-an essential step for capsid disassembly and genome release. Moreover, VCP operates in concert with NPL4 and UFD1, enabling the translocation of SUMOylated Core toward the proteasomal machinery. Collectively, these findings uncover a previously uncharacterized SUMO1-VCP-PSMB2/PSMD2 axis that couples intracellular trafficking with proteasomal disassembly of the CSFV Core, providing mechanistic insights into uncoating and nominating host factors as promising antiviral targets. - Source: PubMed
Publication date: 2025/11/25
Zou Lin-KeBai Ji-ShanSun Rui-CongYang Han-FeiWan Ming-YueZhao Bing-QianSun Bo-TaoChen Jin-XiaChen JingCheng YanZhou Bin - The molecular pathophysiology underlying the development of bronchiectasis with exacerbation at the proteomic level has not been clarified using bronchoalveolar lavage fluid samples. This study aimed to evaluate the bronchoalveolar lavage fluid inflammatory profiles associated with exacerbation of bronchiectasis. - Source: PubMed
Publication date: 2025/10/01
Lee Ju YeonYang JiyoulKim Jin YoungDo YejiKim Min-SikKye Dong EunMin GeonhuiJeon In-SookKim Eung-GookChoi Joong KookChoi MinjaeLee HyunYang Bumhee