Ask about this productRelated genes to: PSMA1 antibody
- Gene:
- PSMA1 NIH gene
- Name:
- proteasome subunit alpha 1
- Previous symbol:
- -
- Synonyms:
- HC2, NU, PROS30, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915
- Chromosome:
- 11p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-03
- Date modifiied:
- 2016-10-05
Related products to: PSMA1 antibody
Related articles to: PSMA1 antibody
- This study aimed to elucidate the molecular mechanism uncoupling inflammation from pathological osteogenesis in radiographic axial spondyloarthritis (r-axSpA), specifically investigating the role of transmembrane TNF (tmTNF) reverse signalling. - Source: PubMed
Publication date: 2026/04/16
Ji PengfeiXu PeitaoJiang JiananCai MingxiYuan ZihaoCao QianLiu ZhidongLiu WenjieXie ZhongyuWang Peng - is recognized as a potential pathogen in gastrointestinal diseases, particularly in patients with chronic intestinal diseases. This study investigates the genomic characteristics, phylogenetic distribution, virulence factors, resistance genes and presence of plasmids in isolates from Slovenian patients with community-acquired infectious diarrhoea. Prospectively collected isolates were analysed using whole-genome sequencing (WGS). WGS analysis revealed substantial genetic diversity among isolates, with distinct differences observed between two genomospecies (GS1, GS2). GS1 isolates had smaller genomes, lower GC content, and fewer coding regions than GS2 isolates. Multilocus sequence typing confirmed a high degree of genetic diversity, with most isolates belonging to novel sequence types. Plasmids, including pSma1 and pICON, were more prevalent in GS2 isolates. The virulence factors Zot and Exo9 toxins were detected in both genomospecies, with Zot predominantly found in GS1 and Exo9 in GS2. The T6 secretion system was prevalent in both groups, whereas the T4SS was less frequently observed. The combination of the T6SS, plasmids, and toxins suggests a complex mechanism of pathogenicity. This study highlights the high genetic diversity of and provides new insights into its genomic features and virulence factors. The presence of plasmids and secretion systems, particularly the T6SS, underscores the potential of for adaptation and pathogenicity. - Source: PubMed
Publication date: 2025/12/31
Kofol RominaPirs MatejaKotar TadejaLejko Zupanc TatjanaCelar Šturm AndražKukec AndrejaMatos TadejaTriglav Tina - Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, partly because epigenetic dysregulation drives tumor progression and metastasis. We previously showed that leucine zipper downregulated in cancer 1 (LDOC1) modulates the metastatic potential of NSCLC cells. The structural features of LDOC1 suggest that it can interact with nuclear histones, and although it lacks a canonical nuclear localization signal, it predominantly localizes to the nucleus in NSCLC cells; its loss causes broad transcriptomic changes, supporting a role for LDOC1 as an epigenetic regulator acting through histone modifications. - Source: PubMed
Publication date: 2026/01/03
Huang Hsien-NengHung Pin-FengTsai Yi-TaLiu En-TingCha Tai-LungChen Ya-PinWeng Wen-TsanSun Chiao-YinYu Wei-HsuanCheng Hau-LunLee Chia-Huei - To identify protein markers that may be associated with ulcerative colitis (UC) by analyzing differential proteins in the salivary exosomes from newly diagnosed patients with active UC and healthy controls (HC), and to investigate the function of salivary exosome-specific high-expression proteins in UC patients and their potential role in the pathogenesis of UC. - Source: PubMed
Yang CongyiZheng XiaowenChen JingyiXu JunChen FengChen YangChen Ning - Glioma is a malignant primary tumor of the brain. In recent years, numerous LncRNAs (Long non-coding RNA) have been demonstrated to be potential targets for glioma, and induction of pyroptosis is one of the important directions to inhibit the malignant process of cancer. The role of LncRNA PSMA-AS1, a novel lncRNA, on glioma remain unclear. The aim of this study was to investigate the effects and mechanisms of LncRNA PSMA-AS1 on glioma. PSMA1-AS1 and its potential targets were analyzed using bioinformatics tools and validated using a dual luciferase reporter gene system. Glioma cells were cultured to detect the expression levels of PSMA1-AS1 and its targets. The levels of PSMA1-AS1 and its targets were regulated by transfection and their effects on the viability and metastatic ability of glioma cells as well as on the level of pyroptosis were examined. PSMA1-AS1 expression was elevated in glioma, where miR-140-3p was a downstream target, and was decreased in glioma cells. Inhibition of PSMA1-AS1 promoted pyroptosis and inhibited glioma cell viability and metastatic ability. Overexpression of miR-140-3p had the same effect as inhibition of PSMA1-AS1, whereas inhibition of miR-140-3p reversed the effect of inhibition of PSMA1-AS1 on glioma cells. In addition, SRSF10 is a downstream binding target of miR-140-3p, and inhibition of SRSF10 also promoted pyroptosis and inhibited glioma cells proliferation and metastasis. In conclusion, our results confirmed that PSMA1-AS1 affects glioma cell proliferation and metastasis by regulating pyroptosis through miR-140-3p/SRSF10 axis, suggesting that LncRNA PSMA1-AS1 may be a potential target for glioma. - Source: PubMed
Publication date: 2025/09/24
Liu ZhengzhengWang MinKuang Weilu