Ask about this productRelated genes to: PRMT8 antibody
- Gene:
- PRMT8 NIH gene
- Name:
- protein arginine methyltransferase 8
- Previous symbol:
- HRMT1L3, HRMT1L4
- Synonyms:
- -
- Chromosome:
- 12p13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-01
- Date modifiied:
- 2016-10-05
Related products to: PRMT8 antibody
Related articles to: PRMT8 antibody
- Protein arginine methyltransferases (PRMTs) catalyze arginine methylation, a key post-translational modification (PTM) regulating chromatin organization, RNA metabolism, and signaling. Recent studies reveal that PRMT-mediated methylation also modulates liquid-liquid phase separation (LLPS), which organizes membraneless condensates controlling transcription, stress response, and genome stability. Dysregulated PRMT activity disrupts condensate dynamics, contributing to cancer and neurodegenerative diseases. In cancer, PRMT1, PRMT5, and PRMT6 promote tumor progression via methylation-dependent condensates that enhance oncogenic transcription and stress resistance. In the nervous system, PRMT1, PRMT4, PRMT5, PRMT6, and PRMT8 regulate LLPS of proteins, linking aberrant methylation to ALS and Huntington's disease. This review highlights PRMTs as key modulators of phase separation and potential therapeutic targets in both oncology and neurodegeneration. - Source: PubMed
Publication date: 2026/07/22
Shen ZhihangYu Qiubin - PRMT8 encodes a protein arginine methyltransferase, which is primarily expressed in the brain and nervous system. Several studies have reported its alterations, which have been implicated in various cancers. However, the existing information remains unsystematic and fragmented due to inconsistency in methodology. This review aims to explore PRMT8 gene alterations in humans, their effects on cellular function and physiology, and their clinical implications. We conducted a narrative literature review covering all publications on PRMT8 alterations across different cancer types, their effect on tumour cell characteristics, and their impact on patient prognosis. Reported PRMT8 alterations include mutations, copy number amplifications, and single-nucleotide polymorphisms, which lead to overexpression or downregulation of PRMT8 protein in tumour cells. PRMT8 alterations compromise the efficacy of both chemotherapy and immune checkpoint inhibitor treatment. These alterations enable tumour cells to maintain pluripotency via activation of the PI3K/AKT/SOX2 signalling pathway, thereby promoting cellular proliferation, invasion, and colony formation. Clinically, these PRMT8 alterations drive disease progression and therapy resistance, resulting in poor prognosis and reduced patient survival. These findings underscore the need to incorporate PRMT8 alterations assessment in clinical practice to guide therapeutic decision-making and improve treatment outcomes in affected patient populations. - Source: PubMed
Publication date: 2026/07/19
Ting Choo-YuenLoon Sheron Goh SirSun Lee BeePin Kee Boon - Alzheimer's disease (AD) is characterized by progressive neurodegeneration driven by tau and amyloid-β (Aβ) pathology, although the underlying molecular mechanisms remain incompletely understood. Emerging evidence implicates altered DNA methylation (DNAm) in AD but comprehensive analyses in experimental models are limited. Here, we profile DNAm dynamics in two widely used transgenic mouse models of tau (rTg4510) and Aβ (J20) neuropathology, focusing on the entorhinal cortex and hippocampus. Using reduced representation bisulfite sequencing (RRBS) and methylation arrays across multiple disease stages, we identified widespread pathology-associated DNAm alterations in both models. Tau pathology in rTg4510 mice was associated with extensive DNAm remodeling at genes involved in neuronal plasticity, apoptosis, and lipid metabolism, including , , and . In contrast, J20 mice exhibited more modest changes, primarily at immune-related loci such as , , and . Tau-associated DNAm changes were more consistent across brain areas than those associated with Aβ pathology. Comparison with human AD DNAm datasets revealed overlapping DNAm differences, including hypermethylation at and in rTg4510 mice. These findings provide robust evidence for early, pathology-associated epigenetic alterations in AD and highlight the utility of epigenomic profiling in transgenic models for identifying novel targets for early intervention in AD. - Source: PubMed
Publication date: 2026/04/07
Leung Szi KayWalker Emma MPolicicchio StefaniaDahir AishaVellame Dorothea SeilerSmith Adam RSwarbrick RhianLunnon KatieDempster Emma LAhmed ZeshanHannon EilisCastanho IsabelMill Jonathan - In recent decades, genetic research in cattle has largely prioritised cosmopolitan breeds and production traits, often overlooking functional and fitness-related characteristics such as longevity, fertility, and udder health. These fitness traits, although critical for animal welfare and sustainable farming, are challenging to improve due to their low heritability and complex genetic background. This study investigates the genomic architecture of three key fitness traits: longevity (LONG), fertility (measured as days open, DO), and udder health (somatic cell score, SCS)-in two local dual-purpose breeds, Alpine Grey (AG) and Rendena (RE), using a genome-wide association study (GWAS). For AG breed, 2 745 genotyped animals were considered and 2 251 from the RE breed. For LONG, 37 053 and 9 782 phenotypic records were, in AG and RE, respectively, while 30 316 (AG) and 19 822 (RE) for DO; and 113 297 (RE) and 792 921 (AG) for both SCS and milk yield. In GWAS, pseudophenotypes were utilised to address data imbalance. A total of 744 quantitative trait loci (QTLs) associated with the three traits were identified, which were associated with 26 annotated genes explaining more than 1% of the additive genetic variance. Candidate genes significantly associated with target traits include CPEB4 (LONG in RE, SCS in both breeds), DSC2 (DO in AG, SCS in RE), LCORL (LONG and SCS in RE), PRMT8 (LONG in both breeds, MY in RE), RAPGEF6 (LONG in AG), TEAD4 (MY in RE), TSPAN9 (LONG in both), and XKR4 (DO and SCS in RE). These genes participate in vital biological functions such as spermatogenesis, mitochondrial regulation, cellular signalling, and tissue integrity, underlining their relevance in fertility, animal health, and productivity. Notably, several genes identified as significant in our study have previously been associated with both milk and beef production traits in the literature, suggesting that key functional traits related to dual-purpose performance remain detectable despite ongoing selection primarily focused on milk yield. This versatility is essential for their continued adaptability to diverse farming systems and market needs. Overall, the findings provide insights into genomic regions associated with fitness traits in local cattle breeds, emphasizing the value of integrating these traits into breeding programmes. The identification of genetic markers offers valuable opportunities to improve selection strategies that promote animal welfare and sustainable production, reinforcing the role of genetic diversity in dual-purpose local breeds within modern agriculture. - Source: PubMed
Publication date: 2026/02/20
Oian AMancin EGomez Proto GRulli ESartori CMantovani R - Beyond follicular-derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers. - Source: PubMed
Publication date: 2026/03/15
Allen David ZHosseini S MohsenZafereo MarkLango MiriamGrubbs Elizabeth GardnerIyer PriyankaPatel Shreyaskumar RRavi VinodBusaidy Naifa LamkiWang Rui JenniferWilliams Michelle DCabanillas Maria EManiakas Anastasios