Ask about this productRelated genes to: PRKCD antibody
- Gene:
- CAVIN3 NIH gene
- Name:
- caveolae associated protein 3
- Previous symbol:
- PRKCDBP
- Synonyms:
- SRBC, HSRBC, MGC20400, cavin-3
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-15
- Date modifiied:
- 2017-03-24
- Gene:
- PRKCD NIH gene
- Name:
- protein kinase C delta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2019-04-23
Related products to: PRKCD antibody
Related articles to: PRKCD antibody
- West-Western screening of a cDNA expression library using 32P-labeled, autophosphorylated protein kinase Cdelta (PKCdelta) as a probe, led us to identify cDNA clones encoding a PKCdelta-binding protein that contains a leucine zipper-like motif in its N-terminal region and two PEST sequences in its C-terminal region. This protein shows overall sequence similarity (43.3%) to the serum deprivation response (sdr) gene product, and we named it SRBC (sdr-related gene product that binds to c-kinase). PKCdelta binds to the C-terminal half of SRBC through the regulatory domain and phosphorylates it in vitro. In COS1 cells, the phosphorylation of over-expressed SRBC is stimulated by 12-O-tetradecanoylphorbol-13-acetate and further enhanced by the over-expression of PKCdelta. The mRNA for SRBC is detected in a wide variety of cultured cell lines and tissues and is strongly induced by serum starvation. Furthermore, SRBC mRNA is induced during retinoic acid-induced differentiation of P19 cells. These results suggest that SRBC serves as a substrate and/or receptor for PKC and might be involved in the control of cell growth mediated by PKC. - Source: PubMed
Izumi YHirai S iTamai YFujise-Matsuoka ANishimura YOhno S