Ask about this productRelated genes to: PRKAR2A antibody
- Gene:
- PRKAR2A NIH gene
- Name:
- protein kinase cAMP-dependent type II regulatory subunit alpha
- Previous symbol:
- PRKAR2
- Synonyms:
- -
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-18
- Date modifiied:
- 2016-10-05
Related products to: PRKAR2A antibody
Related articles to: PRKAR2A antibody
- Pediatric gliomas, comprising both low-grade (LGGs) and high-grade gliomas (HGGs), exhibit significant molecular and clinical heterogeneity. While LGGs generally have a favorable prognosis, HGGs are associated with poor long-term survival despite aggressive treatment. Advances in molecular profiling have enabled targeted therapies, but treatment resistance and tumor heterogeneity remain major challenges. The integration of artificial intelligence (AI) and transcriptomic data holds promise for refining prognostic models and guiding personalized treatment strategies, yet its application in pediatric gliomas remains underexplored. - Source: PubMed
Publication date: 2026/03/09
Li GanglongPei FuyuWang Weizhen - Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD. - Source: PubMed
Jiao YuemiaoWang MinxianQiang GuifenZhao LiXi ZiweiYu YueYin ChengqianSong Guangyuan - Pork is a major source of animal protein worldwide, and its quality is influenced by pre- and post-slaughter procedures. Advances in molecular biology, particularly gene expression studies, support genetic improvement programs by enabling precise strategies to enhance meat quality and economic sustainability. This study evaluated meat quality traits and candidate gene expression in muscle and subcutaneous adipose tissue from different genetic lineages and sexes. A total of 120 pigs from three lineages-Line D (½ Duroc × ½ DB90), Line P (½ Pietrain × ½ DB90), and Line H (½ [Duroc and Pietrain] × ½ DB90); including immunocastrated males (IM) and females, were randomly selected. Meat quality was assessed using physicochemical parameters, and gene expression analysis was performed in 36 pigs using RT-qPCR with , , and as references, and , , , , and PPARGC1A as targets. Lineage influenced drip loss and intramuscular fat, while lineage-sex interaction affected tenderness and color (L* and b*), and sex influenced b*. In muscle, sex affected and , and lineage influenced and . In adipose tissue, only was lineage-dependent. - Source: PubMed
Publication date: 2025/11/21
Gomes Julia DezenSilva Bruna Pereira Martins daDuarte Stefano Francisco PereiraFerreira Soraia VianaCiconello Fernanda NeryAlmeida Vivian Vezzoni dePian Laura WoigtMoncau-Gadbem Cristina TschornyLedur Mônica CorrêaMalaquias Matheus EmanuelBalieiro Júlio César de CarvalhoCesar Aline Silva Mello - β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice. Yet, its cellular responses and mechanistic pathways remain largely uncharacterized. We performed RNA-seq analysis to profile gene expression changes in δ-opioid receptor-expressing HEK293 cells (DOR-HEK), comparing CM-10-treated and untreated conditions. CM-10 exposure led to differential expression of 1714 genes in DOR-HEK cells, with 34 upregulated (>1.4-fold) (1.9%) and 1680 downregulated (<0.71-fold) (98.1%), based on a predicted -value threshold of <0.05. Notably, we identified 10 clusters that were associated with reduced cyclic AMP (cAMP) in DOR-HEK cells following CM-10 treatment. These clusters particularly involved genes related to regulatory subunits of cAMP-dependent protein kinases, such as , cAMP-responsive element-binding pathway, circadian rhythms, such as , , , , and , and anxiety and depression, such as , and . A network with these selected genes was confirmed by STRING analysis. These findings indicate that CM-10 may activate DOR-mediated signaling by suppressing cAMP levels, implicating a distinct molecular cascade in HEK293 cells. - Source: PubMed
Publication date: 2025/10/20
Fukunaga MoeWatanabe ShinOrihara KanamiYamamoto Naoyuki - The host-parasite arms race involves complex molecular crosstalk mediated by protein-protein interactions (PPIs). Bioinformatic analyses can be used to predict both host-parasite PPIs and potential drug targets in parasite genomes, but high-quality genomic data remain scarce for parasitic monogenean flatworms. Herein, an experimental lineage of Gyrodactylus kobayashii (Monopisthocotylea: Gyrodactylidae) is set up on goldfish hosts and used to conduct phased genome assembly using long-range PacBio HiFi and Hi-C technologies. In silico analyses of genomes of three Gyrodactylus species identified innexins as the most promising novel drug candidate genes. Drug screening and experimental verification singled out Imatinib as the most promising drug targeting innexins, with a high efficiency against G. kobayashii (100% mortality at 25 µM within 6 h in vitro) and low toxicity to the host. Prediction of PPIs in three Gyrodactylus-host pairs revealed proteins associated with cAMP-dependent signaling as key candidates, including the host's PRKACB and the parasite's PRKAR2A, RAP1A, ULK2, and Catenin Beta-2. Two interacting G proteins are also identified: GNAO1 and GNB5. As the first high-quality phased chromosome-level genomic assembly for "monogeneans" and the first identification of PPIs in a fish-parasite system, this study significantly advances the understanding of host-parasite interactions at the genomic level. - Source: PubMed
Publication date: 2025/09/29
Zhang DongZhao Jie-MeiXiang Chuan-YuMa Yi-WenLei Hong-PengShi Yu-YingZhou ShunZeng XiaofeiChen JinsongLiu FeiZeng BenheSong RuiHu YeZhang FengLiu XiangLi Wen-XiangWang Gui-TangJakovlić Ivan