Ask about this productRelated genes to: PRCP antibody
- Gene:
- PRCP NIH gene
- Name:
- prolylcarboxypeptidase
- Previous symbol:
- -
- Synonyms:
- PCP, HUMPCP
- Chromosome:
- 11q14
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-06
- Date modifiied:
- 2015-11-09
Related products to: PRCP antibody
Related articles to: PRCP antibody
- Cerebral malaria (CM) due to ( ) infection is a major cause of death in African children. Bradykinin (BK) is a mediator of vasogenic edema. It could contribute to the pathogenesis of central nervous system malaria in Kenyan children and ANKA ( ) infected C57BL/6J mice with experimental cerebral malaria. Cleaved plasma high molecular weight kininogen (cHK) is a marker for prior BK release. 40% of children with central nervous system malaria had plasma cHK versus 18% of children with uncomplicated malaria. Wild-type -infected mice had circulating plasma cHK, elevated BK levels, and reduced HK and prekallikrein levels. HK null ( ), combined BK B1 and B2 receptor null ( ), BK B2 ( ) or BK B1 ( ) receptor null mice were protected from neurologic deterioration and brain edema compared to wild-type mice. mice were not protected from neurological deterioration. Prekallikrein null ( ), prolylcarboxypeptidase hypomorphs ( ), and brain endothelial cell conditional knockout of PRCP ( Cre) mice had reduced neurologic deterioration and brain edema. Adjuvant plasma kallikrein inhibition combined with artesunate treatment of -infected mice reversed neurologic deterioration and brain edema and prolonged survival relative to artesunate alone. BK-induced vasogenic edema contributes to human and murine CM. - Source: PubMed
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